Patents by Inventor Cesar A. Sommer

Cesar A. Sommer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SINGLE LENTIVIRAL VECTOR SYSTEM FOR INDUCED PLURIPOTENT (IPS) STEM CELLS DERIVATION
    Publication number: 20150004703
    Abstract: The present invention is based on the discovery that a single lentiviral vector expressing multiple individual transcription factor proteins from a single multi-cistronic mRNA can reprogram a fibroblast cell to a stem cell-like cell. These reprogrammed induced pluripotent stem (iPS) cells are pluripotent. Additions of the Cre-LoxP sequences into the single lentiviral vector facilitate excision of the vector after reprogramming in achieved. Addition of a maker gene into the single lentiviral vector facilitates detection of the presence of the vector in an iPS. The invention provides compositions and methods of producing iPS cells using a single multi-cistronic lentiviral vector.
    Type: Application
    Filed: September 15, 2014
    Publication date: January 1, 2015
    Applicant: ONE BOSTON MEDICAL CENTER PLACE
    Inventors: Gustavo Mostoslavsky, Cesar A. Sommer
  • Single lentiviral vector system for induced pluripotent (iPS) stem cells derivation
    Patent number: 8865467
    Abstract: The present invention is based on the discovery that a single lentiviral vector expressing multiple individual transcription factor proteins from a single multi-cistronic mRNA can reprogram a fibroblast cell to a stem cell-like cell. These reprogrammed induced pluripotent stem (iPS) cells are pluripotent. Additions of the Cre-LoxP sequences into the single lentiviral vector facilitate excision of the vector after reprogramming in achieved. Addition of a maker gene into the single lentiviral vector facilitates detection of the presence of the vector in an iPS. The invention provides compositions and methods of producing iPS cells using a single multi-cistronic lentiviral vector.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: October 21, 2014
    Assignee: Boston Medical Center Corporation
    Inventors: Gustavo Mostoslavsky, Cesar A. Sommer
  • SINGLE LENTIVIRAL VECTOR SYSTEM FOR INDUCED PLURIPOTENT (IPS) STEM CELLS DERIVATION
    Publication number: 20110236966
    Abstract: The present invention is based on the discovery that a single lentiviral vector expressing multiple individual transcription factor proteins from a single multi-cistronic mRNA can reprogram a fibroblast cell to a stem cell-like cell. These reprogrammed induced pluripotent stem (iPS) cells are pluripotent. Additions of the Cre-LoxP sequences into the single lentiviral vector facilitate excision of the vector after reprogramming in achieved. Addition of a maker gene into the single lentiviral vector facilitates detection of the presence of the vector in an iPS. The invention provides compositions and methods of producing iPS cells using a single multi-cistronic lentiviral vector.
    Type: Application
    Filed: April 6, 2011
    Publication date: September 29, 2011
    Applicant: BOSTON MEDICAL CENTER CORPORATION
    Inventors: Gustavo Mostoslavsky, Cesar A. Sommer