Patents by Inventor Cesar Compadre
Cesar Compadre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220332692Abstract: Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the a-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols.Type: ApplicationFiled: July 5, 2022Publication date: October 20, 2022Applicants: BIOVENTURES, LLC, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Cesar Compadre, Philip J. Breen, Martin Hauer-Jensen, Kottayil Varughese, K. Sree Kumar
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Publication number: 20180244641Abstract: Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the ?-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols.Type: ApplicationFiled: May 2, 2018Publication date: August 30, 2018Applicants: BIOVENTURES, LLC, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Cesar Compadre, Phillip J. Breen, Martin Hauer-Jensen, Kottayil Varughese, K. Sree Kumar
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Patent number: 9309547Abstract: Methods for the synthesis of tocoflexols of Formula (I) and (II) and a number of related tocol analogs are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material.Type: GrantFiled: March 13, 2013Date of Patent: April 12, 2016Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Guangrong Zheng, Cesar Compadre, Martin Hauer-Jensen, Peter Crooks, Philip Breen
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Publication number: 20150087033Abstract: Methods for the synthesis of tocoflexols of Formula (I) and (II) and a number of related tocol analogues are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material.Type: ApplicationFiled: March 13, 2013Publication date: March 26, 2015Inventors: Guangrong Zheng, Cesar Compadre, Martin Hauer-Jensen, Peter Crooks, Philip Breen
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Publication number: 20130158106Abstract: Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the ?-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols.Type: ApplicationFiled: June 2, 2011Publication date: June 20, 2013Applicants: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS, THE BOARD OF TRUSTEES FOR THE UNIVERSITY OF ARKANSASInventors: Philip J. Breen, K. Sree Kumar, Cesar Compadre, Martin Hauer-Jensen, Kottayil Varughese
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Patent number: 8323673Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is useful on food products to prevent microbial growth on the food from a broad spectrum of foodborne microbial contamination. Also disclosed is a method of contacting food products with the dilute QAC for an application time of at least 0.1 second. Foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be 10 treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.Type: GrantFiled: November 4, 2011Date of Patent: December 4, 2012Assignee: University of ArkansasInventors: Cesar Compadre, Philip Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg
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Publication number: 20120071521Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is useful on food products to prevent microbial growth on the food from a broad spectrum of foodborne microbial contamination. Also disclosed is a method of contacting food products with the dilute QAC for an application time of at least 0.1 second. Foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be 10 treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.Type: ApplicationFiled: November 4, 2011Publication date: March 22, 2012Inventors: Cesar COMPADRE, Philip Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg
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Publication number: 20090239912Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.Type: ApplicationFiled: June 1, 2009Publication date: September 24, 2009Inventors: CESAR COMPADRE, Philip Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg
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Patent number: 7541045Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.Type: GrantFiled: September 17, 2004Date of Patent: June 2, 2009Assignee: University of ArkansasInventors: Cesar Compadre, Philip Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg
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Patent number: 7018834Abstract: The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.Type: GrantFiled: June 9, 2003Date of Patent: March 28, 2006Assignee: The Board of Trustees of the University of ArkansasInventors: Richard Drake, Trenton Hinds, Cesar Compadre, Barry Hurlburt, Tammy Rechtin
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Publication number: 20050239850Abstract: A method of using quaternary ammonium compounds for inhibiting attachment of and removing a broad spectrum of foodborne microbial contamination from food products. The method uses quaternary ammonium compounds for inhibiting attachment of and removing microorganisms such as, Staphylococcus, Campylobacter, Arcobacter, Listeria, Aeromonas, Bacillus, Salmonella, non-toxin-producing Escherichia, and pathogenic toxin-producing Escherichia, such as 0157:H7; fungi, such as Aspergillus flavus and Penicillium chrysogenum; and parasites, such as Entameba histolytica from a broad range of food. The foods that can be treated by this method are meat, seafood, vegetables, and fruit. One of the treatment methods is spraying quaternary ammonium compounds on the food products to prevent broad spectrum foodborne microbial contamination.Type: ApplicationFiled: June 24, 2005Publication date: October 27, 2005Inventors: Cesar Compadre, Philip Breen, Hamid Salari, E. Fifer, Danny Lattin, Michael Slavik, Yanbin Li, Timothy O'Brien, Amy Waldroup, Thomas Berg
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Publication number: 20050113012Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.Type: ApplicationFiled: September 17, 2004Publication date: May 26, 2005Inventors: Cesar Compadre, Philip Breen, Hamid Salari, E. Fifer, Danny Lattin, Michael Slavik, Yanbin Li, Timothy O'Brien, Amy Waldroup, Thomas Berg
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Patent number: 6864269Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.Type: GrantFiled: January 31, 2000Date of Patent: March 8, 2005Assignee: University of ArkansasInventors: Cesar Compadre, Philip Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael Slavik, Yanbin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg
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Publication number: 20030202964Abstract: The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.Type: ApplicationFiled: June 9, 2003Publication date: October 30, 2003Applicant: Board of Trustees of the University of ArkansasInventors: Cesar Compadre, Richard Drake, Trenton Hinds, Barry Hurlburt, Tammy Rechtin
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Patent number: 6610289Abstract: The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.Type: GrantFiled: June 8, 2001Date of Patent: August 26, 2003Assignee: The Board of Trustees of the University of ArkansasInventors: Richard Drake, Trenton Hinds, Cesar Compadre, Barry Hurlburt, Tammy Rechtin
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Publication number: 20030021818Abstract: A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.Type: ApplicationFiled: January 31, 2000Publication date: January 30, 2003Inventors: Cesar Compadre, Philip Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael Slavik, Yambin Li, Timothy O'Brien, Amy L. Waldroup, Thomas F. Berg
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Publication number: 20020146796Abstract: The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.Type: ApplicationFiled: June 8, 2001Publication date: October 10, 2002Inventors: Richard Drake, Trenton Hinds, Cesar Compadre, Barry Hurlburt, Tammy Rechtin
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Patent number: 6245543Abstract: The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.Type: GrantFiled: June 22, 1999Date of Patent: June 12, 2001Inventors: Richard Drake, Trenton Hinds, Cesar Compadre, Barry Hurlburt, Tammy Rechtin
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Patent number: 6039992Abstract: A method of using quaternary ammonium compounds for inhibiting attachment of and removing a broad spectrum of foodborne microbial contamination from food products. The method uses quaternary ammonium compounds for inhibiting attachment of and removing microorganisms such as, Staphylococcus, Campylobacter, Arcobacter, Listeria, Aeromonas, Bacillus, Salmonella, non-toxin-producing Escherichia, and pathogenic toxin-producing Escherichia, such as 0157:H7; fungi, such as Aspergillus flavus and Penicillium chrysogenum; and parasites, such as Entameba histolytica from a broad range of food. The foods that can be treated by this method are meat, seafood, vegetables, and fruit. One of the treatment methods is spraying quaternary ammonium compounds on the food products to prevent broad spectrum foodborne microbial contamination.Type: GrantFiled: April 14, 1997Date of Patent: March 21, 2000Assignee: University of ArkansasInventors: Cesar Compadre, Philip Breen, Hamid Salari, E. Kim Fifer, Danny L. Lattin, Michael Slavik, Yanbin Li, Timothy O'Brien
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Patent number: 5855940Abstract: A composition and a method of using the composition for removal and prevention of broad spectrum foodborne microbial contamination in meat products. The method uses quaternary ammonium compounds for inhibiting attachment of and removing a broad spectrum of foodborne microbial contamination from poultry and meat products. The method uses quaternary ammonium compounds for inhibiting attachment of and removing Escherichia coli O157:H7 contamination from meat and poultry products. One of the treatment methods is spraying quaternary ammonium compounds on the poultry and meat products to prevent broad spectrum foodborne microbial contamination. The treatment methods can contact the meat products with the quaternary ammonium compounds for less than 10 minutes and still obtain significant reduction of viable foodborne microorganisms.Type: GrantFiled: April 12, 1996Date of Patent: January 5, 1999Assignee: University of ArkansasInventors: Cesar Compadre, Philip Breen, Hamid Salari, E. Kim Fifer, Danny Lattin, Mike Slavik, Yanbin Li