Abstract: Provided herein are antimicrobial peptides, as well as methods of treating a microbial infection, methods of treating inflammation, and methods of reducing biofilm formation, using the disclosed antimicrobial peptides.

Abstract: Provided are devices for assessing the presence of SARS-CoV-2 in a biological sample, the devices comprising a substrate comprising a top surface and a back surface; and, an electrode on the top surface of the substrate, wherein the electrode is functionalized with a detection moiety that binds SARS-CoV-2 spike protein. Also disclosed are articles that include such devices, and methods for assessing the presence of SARS-CoV-2 in a biological sample using the disclosed devices. The present disclosure also provides devices for assessing the presence of herpes simplex virus (HSV) in a biological sample comprising a substrate that includes a top surface and a back surface; and, an electrode on the top surface of the substrate, wherein the electrode is functionalized with a detection moiety that binds HSV glycoprotein gD2, such as nectin-1. Also disclosed are articles that include such devices, and methods for assessing the presence of HSV in a biological sample using the disclosed devices.

Abstract: Provided herein are synthetic peptides with enhanced antimicrobial and antibiofilm characteristics, and are biocompatible with mammalian cellular systems. The disclosed synthetic antimicrobial moieties include a mastoparan peptide having SEQ ID NO:1 and a pentapeptide motif formed from phenylalanine, leucine, proline, and two isoleucine residues, wherein the pentapeptide motif is conjugated the N-terminus of the mastoparan peptide. Also provided are compositions comprising the synthetic peptides, as well as methods of treating a microbial infection or removing a biofilm using the peptides.

Abstract: Provided herein are synthetic peptides with enhanced antimicrobial and antibiofilm characteristics, and are biocompatible with mammalian cellular systems. The disclosed synthetic antimicrobial moieties include a peptide portion and an amino-terminal Cu(II) and Ni(II) binding motif that is conjugated to the N-terminus of the peptide portion. Also provided are compositions comprising the synthetic peptides, as well as methods of treating a microbial infection or removing a biofilm using the peptides.

Abstract: Described herein are methods of physicochemical-guided peptide design that utilize specific functional determinants to a protein's property of interest. Also described herein are novel synthetic peptide antibiotics that have increased potency and/or decreased toxicity relative to the template peptide from which they were derived, and methods of use thereof in treating microbial infections.

Abstract: Disclosed are polymer-coated surfaces encapsulating task specific ionic liquids (ILs), IL complexes, or oils. Also disclosed are polymer-coated surfaces, wherein the polymer comprises ILs or neutral ethylene diamine compounds. Also disclosed are methods of antimicrobial treatment, metal remediation, and gas absorption using polymer coatings encapsulating ILs, IL complexes, and oils or polymer coatings comprising ILs and neutral ethylene diamine compounds.

Abstract: Disclosed herein are methods of designing peptides having at least one property of interest, such as ?-helical propensity, higher net charge, hydrophobicity, and/or hydrophobic moment. Also disclosed herein are novel artificially evolved peptides (e.g., antimicrobial peptides), which may be designed according to the methods described herein, and methods of use thereof.

Abstract: Disclosed are methods of antimicrobial treatment using ionic liquids (ILs), IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds. Also disclosed are novel IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds.

Abstract: Disclosed are polymer-coated surfaces encapsulating task specific ionic liquids (ILs), IL complexes, or oils. Also disclosed are polymer-coated surfaces, wherein the polymer comprises ILs or neutral ethylene diamine compounds. Also disclosed are methods of antimicrobial treatment, metal remediation, and gas absorption using polymer coatings encapsulating ILs, IL complexes, and oils or polymer coatings comprising ILs and neutral ethylene diamine compounds.

Abstract: Disclosed are methods of antimicrobial treatment using ionic liquids (ILs), IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds. Also disclosed are novel IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds.

Abstract: The present invention relates generally to peptides and more specifically to anti-biofilm and immunomodulatory peptides.

Abstract: Disclosed herein are methods of designing peptides having at least one property of interest, such as ?-helical propensity, higher net charge, hydrophobicity, and/or hydrophobic moment. Also disclosed herein are novel artificially evolved peptides (e.g., antimicrobial peptides), which may be designed according to the methods described herein, and methods of use thereof.

Abstract: The present invention relates generally to peptides and more specifically to anti-biofilm and immunomodulatory peptides.