Patents by Inventor Cesar G. Albarino

Cesar G. Albarino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant rift valley fever (RVF) viruses and methods of use
    Patent number: 10064933
    Abstract: Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: September 4, 2018
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
    Inventors: Brian H. Bird, Cesar G. Albarino, Stuart T. Nichol, Thomas G. Ksiazek
  • Rift valley fever virus replicon particles and use thereof
    Patent number: 9687542
    Abstract: Disclosed herein is a robust system for the reverse genetics generation of a Rift Valley fever (RVF) virus replicon particle (VRPRVF) vaccine candidate. VRPRVF can actively synthesize viral RNA and proteins, but lack structural glycoprotein genes, preventing spread within immunized individuals and reducing the risk of vaccine-induced pathogenicity. Is it disclosed herein that VRPRVF immunization is both safe and efficacious, resulting in a robust immune response that is protective against RVF virus challenge within 24 hours of immunization. Provided herein are VRPRVF, methods of producing VRPRVF, and method of using VRPRVF for immunization against RVF virus infection.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: June 27, 2017
    Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Kimberly A. Dodd, Brian H. Bird, Cesar G. Albarino, Stuart T. Nichol
  • RECOMBINANT RIFT VALLEY FEVER (RVF) VIRUSES AND METHODS OF USE
    Publication number: 20160331827
    Abstract: Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 17, 2016
    Applicant: The Government of the U.S.A. as represented by the Secretary of the Dept. of Health and Human Servic
    Inventors: Brian H. Bird, Cesar G. Albarino, Stuart T. Nichol, Thomas G. Ksiazek
  • Recombinant rift valley fever (RVF) viruses and methods
    Patent number: 9439935
    Abstract: Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: September 13, 2016
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
    Inventors: Brian H. Bird, Cesar G. Albarino, Stuart T. Nichol, Thomas G. Ksiazek
  • RIFT VALLEY FEVER VIRUS REPLICON PARTICLES AND USE THEREOF
    Publication number: 20150196630
    Abstract: Disclosed herein is a robust system for the reverse genetics generation of a Rift Valley fever (RVF) virus replicon particle (VRPRVF) vaccine candidate. VRPRVF can actively synthesize viral RNA and proteins, but lack structural glycoprotein genes, preventing spread within immunized individuals and reducing the risk of vaccine-induced pathogenicity. Is it disclosed herein that VRPRVF immunization is both safe and efficacious, resulting in a robust immune response that is protective against RVF virus challenge within 24 hours of immunization. Provided herein are VRPRVF, methods of producing VRPRVF, and method of using VRPRVF for immunization against RVF virus infection.
    Type: Application
    Filed: June 18, 2013
    Publication date: July 16, 2015
    Inventors: Kimberly A. Dodd, Brian H. Bird, Cesar G. Albarino, Stuart T. Nichol
  • RECOMBINANT RIFT VALLEY FEVER (RVF) VIRUSES AND METHODS OF USE
    Publication number: 20140134207
    Abstract: Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
    Type: Application
    Filed: January 24, 2014
    Publication date: May 15, 2014
    Applicant: The Government of the United States of America as represented by the Secretary of the Dept. of He
    Inventors: Brian H. Bird, Cesar G. Albarino, Stuart T. Nichol, Thomas G. Ksiazek
  • Recombinant Rift Valley fever (RVF) viruses and methods of use
    Patent number: 8673629
    Abstract: Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: March 18, 2014
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services Centers for Disease Control and Prevention
    Inventors: Brian H. Bird, Cesar G. Albarino, Stuart T. Nichol, Thomas G. Ksiazek
  • RECOMBINANT RIFT VALLEY FEVER (RVF) VIRUSES AND METHODS OF USE
    Publication number: 20110123567
    Abstract: Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
    Type: Application
    Filed: December 16, 2008
    Publication date: May 26, 2011
    Applicants: HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION
    Inventors: Brian H. Bird, Cesar G. Albarino, Stuart T. Nichol, Thomas G. Ksiazek