Patents by Inventor Cesar Milstein
Cesar Milstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140087481Abstract: The present invention relates to the use of cluster of differentiation (CD) molecules in detecting the presence and progression of one or more disease states in an individual. In particular it relates to the use of profiles of shed CD (sCD) molecules in detecting and assessing the progression of one or more disease states in an individual. Further uses of sCD profiles according to the present invention are also described.Type: ApplicationFiled: September 13, 2013Publication date: March 27, 2014Applicants: Medical Research Council, Cambridge Enterprise LimitedInventors: Adrian Woolfson, Charles Nicholas Hales, Cesar Milstein
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Publication number: 20120237500Abstract: This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through the detection and analysis of soluble CD antigens in a body fluid sample.Type: ApplicationFiled: May 29, 2012Publication date: September 20, 2012Applicants: CAMBRIDGE ENTERPRISE LIMITED, MEDICAL RESEARCH COUNCILInventors: Cesar Milstein, Celia Prilleltensky-Milstein, Charles Nicholas Hales, Margaret Hales, Adrian Woolfson
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Patent number: 8206907Abstract: This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through the detection and analysis of soluble CD antigens in a body fluid sample.Type: GrantFiled: September 25, 2008Date of Patent: June 26, 2012Assignees: Medical Research Council, Cambridge Enterprise LimitedInventors: Cesar Milstein, Celia Prilleltensky-Milstein, legal representative, Charles Nicholas Hales, Margaret Hales, legal representative, Adrian Woolfson
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Publication number: 20090181863Abstract: This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through the detection and analysis of soluble CD antigens in a body fluid sample.Type: ApplicationFiled: September 25, 2008Publication date: July 16, 2009Applicants: Cambridge University Technical Services Limited (CUTS), Medical Research Council, Addenbrookes NHS TrustInventors: Cesar Milstein, Celia Prilleltensky-Milstein, Charles Nicholas Hales, Margaret Hales, Adrian Woolfson
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Publication number: 20080318836Abstract: The present invention relates to the use of cluster of differentiation (CD) molecules in detecting the presence and progression of one or more disease states in an individual. In particular it relates to the use of profiles of shed CD (sCD) molecules in detecting an assessing the progress of one or more disease states in an individual. Further uses of sCD profiles according to the present invention are also described.Type: ApplicationFiled: March 28, 2008Publication date: December 25, 2008Applicants: Medical Researach CouncilInventors: Adrian Woolfson, Charles Nicholas Hales, Margaret Hales, Cesar Milstein, Celia Prilleltensky Milstein
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Publication number: 20070233391Abstract: The present invention relates to the use of cluster of differentiation (CD) molecules in detecting the presence and progression of one or more disease states in an individual. In particular it relates to the use of profiles of shed CD (sCD) molecules in detecting and assessing the progression of one or more disease states in an individual. Further uses of sCD profiles according to the present invention are also described.Type: ApplicationFiled: March 7, 2003Publication date: October 4, 2007Applicants: Cambridge University Technical Service Limited (CUTS), Medical Research Council, Addenbrookes NHS TrustInventors: Cesar Milstein, Celia Milstein, Adrian Woolfson, Charles Hales, Margaret Hales
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Patent number: 5426037Abstract: Apparatus and method for the production of monoclonal antibodies, wherein a sealed dialysis tube (18) is fixed within a roller bottle (10) to be immersed in a growth medium (24) contained within the roller bottle, the dialysis tube is filled with a culture of hybridomas (20) to the extent that a bubble (22) remains within the tube, and the bottle is rotated or otherwise moved in order to cause the bubble to oscillate back and forth from one end of the tube to the other.Type: GrantFiled: December 14, 1993Date of Patent: June 20, 1995Assignee: Medical Research CouncilInventors: Richard Pannell, Cesar Milstein
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Patent number: 4472500Abstract: A rat myeloma cell line which does not express an immunoglobulin chain, YB2/3.0.Ag.20, is prepared from the cell line Y3-Ag 1.2.3 via a hybrid myeloma cell line. This cell line, and variants thereof prepared by passaging and/or cloning the line, may be fused with immunocyte cells from an animal sensitized to an immunogen to produce hybrid myeloma cell lines which provide a source of monoclonal antibodies to said immunogen.Type: GrantFiled: July 7, 1981Date of Patent: September 18, 1984Assignee: National Research Development CorporationInventors: Cesar Milstein, Bruce W. Wright
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Patent number: 4350683Abstract: Hybrid cell lines for providing antibodies are produced from a rat myeloma cell line having the C.N.C.M. designation I-078. In production of the hybrid cells, the rat myeloma cell line is fused with immunocyte cells such as spleen cells from an animal such as a rat sensitized to an immunogen. Use of the rat myeloma cell line is particularly advantageous for in vivo cultivation of a hybrid cell line to produce antibodies.Type: GrantFiled: January 3, 1980Date of Patent: September 21, 1982Assignee: National Research Development CorporationInventors: Giovanni Galfre, Cesar Milstein, Bruce W. Wright
