Patents by Inventor Cesare Casagrande

Cesare Casagrande has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compound for the treatment of atherosclerotic-thrombotic pathological conditions
    Patent number: 6525078
    Abstract: 4-Methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide and acid addition salts thereof with pharmaceutically acceptable organic and inorganic acids, and a pharmaceutical composition containing the same, for the treatment of vascular diseases involving atherosclerotic-thrombotic conditions and of other pathological conditions as shown in the description.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: February 25, 2003
    Inventor: Cesare Casagrande
  • Pharmaceutical composition useful for the treatment of cardiovascular diseases
    Patent number: 5571834
    Abstract: A pharmaceutical composition is described comprising ibopamine and an ACE-inhibitor.Such composition is useful in the treatment of cardiovascular diseases, more particularly of hypertension and heart insufficiency even when the latter is associated with or caused by hypertension.
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: November 5, 1996
    Assignee: Zambon Group S.p.A.
    Inventors: Cesare Casagrande, Luciano Licciardello
  • Pharmaceutical compositions containing N-acetyl-cysteine derivatives useful for the treatment of cataract
    Patent number: 5519054
    Abstract: Pharmaceutical compositions for the treatment of cataract containing N-acetyl-L-cysteine derivatives of formula ##STR1## (wherein R and R.sub.1 have the meanings reported in the specification) are described.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: May 21, 1996
    Assignee: Zambon Group S.p.A.
    Inventors: Francesco Santangelo, Giorgio Bertolini, Franco Pellacini, Luciano Soldati, Annibale Gazzaniga, Cesare Casagrande
  • Compounds active on the cardiovascular system
    Patent number: 5468746
    Abstract: Compounds of the formula ##STR1## (wherein Ar, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, m and n have the meanings given in the description), their preparation and pharmaceutical compositions containing them.The compounds of formula I are active on the cardiovascular system as antivasospastics, antiangina agents, antihypertensives and vasodilators.
    Type: Grant
    Filed: June 21, 1991
    Date of Patent: November 21, 1995
    Assignee: Zambon Group S.p.A.
    Inventors: Cesare Casagrande, Stefania Montanari, Francesco Santangelo
  • 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovasular system, processes for their preparation and pharmaceutical compositions containing them
    Patent number: 5451608
    Abstract: Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene and their use in therapeutic field are described.The compounds are particularly useful in the treatment of arterial hypertension, cardiac decompensation and renal failure, in the treatment of peripheral arteriopathies and in cerebrovascular insufficiency.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: September 19, 1995
    Assignee: Zambon Group S.p.A.
    Inventors: Francesco Santangelo, Giorgio Bertolini, Cesare Casagrande, Francesco Marchini, Stefania Montanari, Claudio Semeraro
  • Diphosphates of catecholamines and pharmaceutical compositions containing them
    Patent number: 5438047
    Abstract: Diphosphates of catecholamines having formula (I) wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X have the meanings reported in the description, are useful in the therapy of cardiovascular and renal diseases.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: August 1, 1995
    Assignee: Zambon Group S.p.A.
    Inventors: Francesco Santangelo, Cesare Casagrande, Gabriele Norcini
  • Steroid compounds active on the cardiovascular system
    Patent number: 5426179
    Abstract: Steroid compounds active on the cardiovascular system of formula ##STR1## wherein X, n, R, R.sub.1 and R.sub.2 have the meanings mentioned in the description are described.
    Type: Grant
    Filed: February 12, 1992
    Date of Patent: June 20, 1995
    Assignee: Zambon Group S.p.A.
    Inventors: Giorgio Bertolini, Cesare Casagrande, Stefania Montanari, Gabriele Norcini, Francesco Santangelo
  • 17-aryl-substituted steroidal compounds active on the cardiovascular system
    Patent number: 5424304
    Abstract: Cardioactive steroidal compounds of the formula I ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 have the meanings shown in the description, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: June 13, 1995
    Inventors: Giorgio Bertolini, Cesare Casagrande, Gabriele Norcini, Francesco Santangelo
  • 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them
    Patent number: 5407956
    Abstract: Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene and their use in therapeutic field are described.The compounds are particularly useful in the treatment of arterial hypertension, cardiac decompensation and renal failure, in the treatment of peripheral arteriopathies and in cerebrovascular insufficiency.
    Type: Grant
    Filed: March 17, 1993
    Date of Patent: April 18, 1995
    Assignee: Zambon Group S.p.A.
    Inventors: Francesco Santangelo, Giorgio Bertolini, Cesare Casagrande, Francesco Marchini, Stefania Montanari, Claudio Semeraro
  • Pharmaceutical composition useful for the treatment of cardiovascular diseases
    Patent number: 5304570
    Abstract: A pharmaceutical composition is described comprising ibopamine and an ACE-inhibitor. Such composition is useful in the treatment of cardiovascular diseases, more particularly of hypertension and heart insufficiency even when the latter is associated with or caused by hypertension.
    Type: Grant
    Filed: July 11, 1989
    Date of Patent: April 19, 1994
    Assignee: Zambon Group S.P.A.
    Inventors: Cesare Casagrande, Luciano Licciardello
  • Process for the preparation of 2-amino-5,6-dimethoxy-tetralin
    Patent number: 5221770
    Abstract: A process is disclosed for the preparation of 2-amino-5,6-dimethoxy-tetralin, which is a useful intermediate for the preparation of pharmacologically active chemical compounds.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: June 22, 1993
    Assignee: Zambon Group S.p.A.
    Inventors: Giorgio Bertolini, Cesare Casagrande, Francesco Santangelo
  • Compounds active as inhibitors of the cholesterol biosynthesis
    Patent number: 5196440
    Abstract: The compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 have the meanings given in the specification, as described.The compounds of formula I are active as inhibitors of the enzyme HMG-CoA reductase and can be used in therapy as anti-hypercholesterolemics.
    Type: Grant
    Filed: May 4, 1990
    Date of Patent: March 23, 1993
    Assignee: Zambon Group S.p.A.
    Inventors: Giorgio Bertolini, Cesare Casagrande, Francesco Santangelo
  • Phenoxyethyl amine compounds active on the cardiovascular system
    Patent number: 5151414
    Abstract: Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2, R.sub.3, n, m and p have the meanings reported in the specification), their preparation and the compositions for pharmaceutical use containing them as active ingredient are described.The compounds of formula I have dopaminergic vasodilator activity and they may be used in pharmaceutical field.
    Type: Grant
    Filed: July 31, 1991
    Date of Patent: September 29, 1992
    Assignee: SIMES Societa Italiana Medicinali e Sintetici S.p.A.
    Inventors: Cesare Casagrande, Gabriele Norcini, Francesco Santangelo, Claudio Semeraro
  • Catecholamine esters
    Patent number: 5144059
    Abstract: The compound of the formula ##STR1## (wherein R, R.sub.1 and R.sub.2 have the meanings given in the description), salts thereof with pharmaceutically acceptable organic or inorganic acids, process and intermediates for the preparation thereof and a pharmaceutical composition containing said compound are described.The compounds of formula I and the salts thereof are useful in the treatment of heart and renal diseases.
    Type: Grant
    Filed: April 20, 1990
    Date of Patent: September 1, 1992
    Assignee: Simes Societa Italiana Medicinali E. Sintetici S.A.
    Inventors: Cesare Casagrande, Francesco Santangelo
  • Process for the preparation of 4-O-phosphates of dopamine and dopamine derivatives
    Patent number: 5138084
    Abstract: A process for the preparation of 4-O-phosphates of dopamine and dopamine derivatives by treatment of a mixture of both 3-O-phosphate and 4-O-phosphate isomers with a strong mineral acid and optional esterification of the so obtained phosphoric ester of dopamine or dopamine derivatives is described.
    Type: Grant
    Filed: November 14, 1990
    Date of Patent: August 11, 1992
    Assignee: SIMES Societa Italiana Medicinali e Sintetici S.p.A.
    Inventors: Cesare Casagrande, Francesco Santangelo
  • 1,2,3-triazole compounds active as inhibitors of the enzyme HMG-CoA reductase and pharmaceutical compositions containing them
    Patent number: 5081136
    Abstract: Compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and Z have the meanings reported in the specification,and intermediates for their preparation are described. The compounds of formula I have antiatherosclerotic activity as inhibitors of the enzyme HMG-CoA reductase and they are useful in the pharmaceutical field. Compositions for pharmaceutical use containing a compound of formula I as active ingredient are described too.
    Type: Grant
    Filed: December 13, 1990
    Date of Patent: January 14, 1992
    Assignee: Zambon Group S.p.A.
    Inventors: Girogio Bertolini, Cesare Casagrande, Francesco Santangelo
  • Dopamine pro-drug
    Patent number: 5073547
    Abstract: A monophosphorylated L-dopa ester of formula ##STR1## (wherein the asterisk, R, R.sub.1, R.sub.2 and R.sub.3 have the meanings shown in the description),salts thereof with pharmaceutically acceptable acids or bases, a process for the preparation thereof and a pharmaceutical composition containing said compound or a salt thereof are described.The compound of formula I and the salts thereof are useful in the treatment of Parkinson's disease, renal failure, heart failure and hypertension.
    Type: Grant
    Filed: April 20, 1990
    Date of Patent: December 17, 1991
    Assignee: Simes Societa Italiana Medicinali e Sintetici S.p.A.
    Inventors: Cesare Casagrande, Francesco Santangelo
  • Compounds active on the cardiovascular system
    Patent number: 5070106
    Abstract: Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2, R.sub.3, n, m, and p have the meanings reported in the specification), their preparation and the compositions for pharmaceutical use containing them as active ingredient are described.The compounds of formula I have dopaminergic vasodilator activity and they may be used in pharmaceutical field.
    Type: Grant
    Filed: February 22, 1991
    Date of Patent: December 3, 1991
    Assignee: Simes Societa Italiana Medicinali e Sintetici S.p.A.
    Inventors: Cesare Casagrande, Gabriele Norcini, Francesco Santangelo, Claudio Semeraro
  • Amine derivatives having cardiovascular activity
    Patent number: 5047425
    Abstract: Compounds of the formula ##STR1## wherein Ar, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X and n have the meanings mentioned in the description, processes and intermediates for their preparation, pharmaceutical compositions which contain them and their use in therapy in the treatment of cardiovascular diseases.
    Type: Grant
    Filed: November 30, 1988
    Date of Patent: September 10, 1991
    Assignee: Simes Societa Italiana Medicinali & Sintetici SpA
    Inventors: Cesare Casagrande, Francesco Santangelo, Luisa Calabi
  • Fused pyridines active on the cardiovascular system
    Patent number: 5025011
    Abstract: Compounds of the formula ##STR1## (wherein Ar, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X and m have the meanings given in the description), their preparation and pharmaceutical compositions containing them.The compounds of formula I are active on the cardiovascular system as antivasospastics, antiangina pectoris agents, antihypertensives and vasodilators.
    Type: Grant
    Filed: July 25, 1989
    Date of Patent: June 18, 1991
    Assignee: SIMES, Societa Italiana Medicinali e Sintetici S.p.A.
    Inventors: Cesare Casagrande, Stefania Montanari, Francesco Santangelo