Patents by Inventor Cesare Ponzone

Cesare Ponzone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11241470
    Abstract: Extract obtainable by extraction from Phaseolus sp. with mixtures of ethanol and water, characterised by an ?-amylase inhibitor content in between 1,000 and 1,600 USP/mg (HPLC titre between 6 and 14% w/w) and a phytohaemagglutinin content in between 8,000 and 30,000 HAU/g, and a process for its preparation.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: February 8, 2022
    Assignee: INDENA S.P.A.
    Inventors: Davide Berlanda, Marco Bertani, Ezio Bombardelli, Andrea Gardi, Cesare Ponzone, Fabio Donzelli
  • Patent number: 10563270
    Abstract: Disclosed are solid forms of menaquinol and processes for obtaining them by chemical or enzymatic reduction of menaquinone. Said solid forms possess high stability to oxidation which allows effective use of menaquinol in the most common formulations wherein vitamin K2 is used.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: February 18, 2020
    Assignee: Gnosis S.p.A.
    Inventors: Davide Bianchi, Simona Daly, Niccolo Miraglia, Antonella Trentin, Federica Colzani, Francesca Bollini, Cesare Ponzone
  • Publication number: 20180066326
    Abstract: Disclosed are solid forms of menaquinol and processes for obtaining them by chemical or enzymatic reduction of menaquinone. Said solid forms possess high stability to oxidation which allows effective use of menaquinol in the most common formulations wherein vitamin K2 is used.
    Type: Application
    Filed: March 18, 2016
    Publication date: March 8, 2018
    Applicant: Gnosis S.p.A.
    Inventors: Davide Bianchi, Simona Daly, Niccolo Miraglia, Antonella Trentin, Federica Colzani, Francesca Bollini, Cesare Ponzone
  • Patent number: 8569455
    Abstract: A truncated form of ?? chain (e??), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast Pichia pastoris. The recombinant polypeptide spanned 142 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean alpha? subunit. The e?? polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: October 29, 2013
    Assignee: Indena S.p.A.
    Inventors: Paolo Morazzoni, Antonella Riva, Cesare Ponzone, Davide Berlanda, Marcello Duranti, Alessandro Consonni
  • Publication number: 20120172316
    Abstract: A truncated form of ?? chain (e??), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast Pichia pastoris. The recombinant polypeptide spanned 142 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean alpha? subunit. The e?? polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL.
    Type: Application
    Filed: June 16, 2010
    Publication date: July 5, 2012
    Applicant: INDENA S.P.A.
    Inventors: Paolo Morazzoni, Antonella Riva, Cesare Ponzone, Davide Berlanda, Marcello Duranti, Alessandro Consonni
  • Patent number: 7910334
    Abstract: The present invention relates to a biotransformation process, effected by means of selected microbial strains, for the preparation of 3-O-glycosyl derivatives of colchicinoid compounds.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: March 22, 2011
    Assignee: Indena S.p.A.
    Inventor: Cesare Ponzone
  • Patent number: 7887854
    Abstract: The present invention relates to a Cynara scolymus extract with a high content of caffeoylquinic acids, and a composition containing said Cynara scolymus extract with a Phaseolus vulgaris extract. Said composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitising the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated in Oenothera biennis oil, fish oil, or oils rich in unsaturated ?-3 fatty acids.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: February 15, 2011
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • Patent number: 7887855
    Abstract: The present invention relates to a Cynara scolymus extract with a high content of caffeoylquinic acids, and a composition containing said Cynara scolymus extract with a Phaseolus vulgaris extract. Said composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitizing the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated in Oenothera biennis oil, fish oil, or oils rich in unsaturated ?-3 fatty acids.
    Type: Grant
    Filed: March 6, 2008
    Date of Patent: February 15, 2011
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • Publication number: 20090169657
    Abstract: Extract obtainable by extraction from Phaseolus sp. with mixtures of ethanol and water, characterised by an ?-amylase inhibitor content in between 1,000 and 1,600 USP/mg (HPLC titre between 6 and 14% w/w) and a phytohaemagglutinin content in between 8,000 and 30,000 HAU/g, and a process for its preparation.
    Type: Application
    Filed: December 13, 2006
    Publication date: July 2, 2009
    Inventors: Davide Berlanda, Marco Bertani, Ezio Bombardelli, Fabio Donzelli, Andrea Gardi, Cesare Ponzone
  • Patent number: 7553502
    Abstract: This invention relates to the combination of ?-amylase inhibitors prepared from Phaseolus vulgaris with ?-glucosidase inhibitors obtained from Salacia oblonga and other species. The ?-amylase inhibitor is accompanied by a quantity of lectins that reduces the amount of glucose originating from the starches present in the diet, and considerably reduces the appetite after repeated administration. The combination with ?-glucosidase inhibitors, such as extracts of Salacia or the thiosugars present in it, further reduce the blood glucose, acting synergically, and consequently reduce the synthesis of fats from carbohydrates.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: June 30, 2009
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • Publication number: 20090093397
    Abstract: Extracts obtainable by extraction from Phaseolus sp. with aqueous solutions, characterised by an ?-amylase inhibitor content with an activity equal to or greater than 1,800 USP/mg (HPLC titre equal to or greater than 15% w/w) and a phytohaemagglutinin content of between 1,500 and 6,000 HAU/g, and a process for its preparation.
    Type: Application
    Filed: December 13, 2006
    Publication date: April 9, 2009
    Inventors: Davide Berlanda, Marco Bertani, Ezio Bombardelli, Fabio Donzelli, Andrea Gardi, Cesare Ponzone
  • Publication number: 20090011479
    Abstract: The present invention relates to a biotransformation process, effected by means of selected microbial strains, for the preparation of 3-O-glycosyl derivatives of colchicinoid compounds.
    Type: Application
    Filed: May 12, 2004
    Publication date: January 8, 2009
    Applicant: INDENA S.p.A.
    Inventor: Cesare Ponzone
  • Publication number: 20080220096
    Abstract: The present invention relates to a Cynara scolymus extract with a high caffeoylquinic acid content, obtainable by extraction from undried globe artichoke heads with alcohols having up to three carbon atoms.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 11, 2008
    Applicant: INDENA S. P. A.
    Inventors: Ezio Bombardelli, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • Publication number: 20080220098
    Abstract: This invention relates to the combination of ?-amylase inhibitors prepared from Phaseolus vulgaris with ?-glucosidase inhibitors obtained from Salacia oblonga and other species. The ?-amylase inhibitor is accompanied by a quantity of lectins that reduces the amount of glucose originating from the starches present in the diet, and considerably reduces the appetite after repeated administration. The combination with ?-glucosidase inhibitors, such as extracts of Salacia or the thiosugars present in it, further reduce the blood glucose, acting synergically, and consequently reduce the synthesis of fats from carbohydrates.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 11, 2008
    Applicant: INDENA S.P.A.
    Inventors: Ezio BOMBARDELLI, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • Publication number: 20080220097
    Abstract: The present invention relates to a Cynara scolymus extract with a high content of caffeoylquinic acids, and a composition containing said Cynara scolymus extract with a Phaseolus vulgaris extract. Said composition is useful in reducing obesity as it reduces cholesterol, triglycerides and blood glucose by sensitising the cells to insulin. This combination, when taken before meals, reduces the appetite, leading to a reduction in body weight. The extracts are preferably formulated in Oenothera biennis oil, fish oil, or oils rich in unsaturated ?-3 fatty acids.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 11, 2008
    Applicant: INDENA S.P.A.
    Inventors: Ezio BOMBARDELLI, Gabriele Fontana, Andrea Giori, Paolo Morazzoni, Cesare Ponzone, Massimo Ronchi
  • Publication number: 20060257527
    Abstract: The invention relates to a process for the preparation of a vanilla extract, which process consists in subjecting vanilla green beans to accelerated browning followed by extractive/enzymatic treatment.
    Type: Application
    Filed: December 22, 2003
    Publication date: November 16, 2006
    Inventors: Cesare Ponzone, Marco Bertani
  • Patent number: 6911325
    Abstract: A process for the preparation of desglucodesrhamnoruscin which comprises the enzymatic hydrolysis of Ruscus Aculeatus steroid glycosides (ruscosaponins) by means of crude hydrolases from aspergillus niger.
    Type: Grant
    Filed: May 29, 2000
    Date of Patent: June 28, 2005
    Assignee: Indena S.p.A.
    Inventors: Cesare Ponzone, Mario De Rosa, Alessandra Morana, Antonella Di Lazzaro
  • Patent number: 6528280
    Abstract: A process for the preparation of desglucodesrhamnoruscin which comprises the hydrolysis of Ruscus Aculeatus steroid glycosides (ruscosaponins) through fermentation of a substrate containing said glycosides by means of fungi of the aspergillus niger species.
    Type: Grant
    Filed: January 15, 2002
    Date of Patent: March 4, 2003
    Assignee: Indena S.p.A.
    Inventors: Walter Acquati, Cesare Ponzone
  • Patent number: 6372458
    Abstract: The present invention relates to the microbial biotransformation of colchiconic compounds into derivative compounds, which are glycosylated exclusively at the C-3 position of the six-member ring. The process of the present invention provides the 3-O-glycosyl derivatives in high yields and purity.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: April 16, 2002
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Cesare Ponzone
  • Patent number: 6150140
    Abstract: Colchicinoid compounds are transformed into the corresponding 3-O-glycosyl derivatives by means of Bacillus megaterium strains.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: November 21, 2000
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Cesare Ponzone