Abstract: An intraocular pressure (IOP) sensing system may comprise an intraocular pressure sensing implant to be implanted into the eye of a patient for capturing absolute intraocular pressure measurements and an external device for capturing atmospheric pressure measurements. The intraocular pressure sensing implant may be configured to capture an absolute intraocular pressure measurement at an appointed time, and the external device may be configured to capture a plurality of atmospheric pressure measurements around the appointed time.

Abstract: An intraocular pressure (IOP) sensing system may comprise an intraocular pressure sensing implant to be implanted into the eye of a patient for capturing absolute intraocular pressure measurements and an external device for capturing atmospheric pressure measurements. The intraocular pressure sensing implant may be configured to capture an absolute intraocular pressure measurement at an appointed time, and the external device may be configured to capture a plurality of atmospheric pressure measurements around the appointed time.

Abstract: Intraocular physiological sensor implants include a physiological sensor and a fluid pathway including a fluid inlet and a fluid outlet. The physiological sensor includes a sensing layer, a coil layer, and an integrated circuit layer. The intraocular pressure sensor provides trabecular bypass flow. The intraocular pressure sensor detects intraocular pressure, to identify patient conditions such as glaucoma.

Abstract: An exemplary illumination system is provided herein for use in performing an ophthalmic surgical procedure. The illumination system may include a body configured to be held by a hand of a user. The body may include an outer surface and an inner surface that defines an inner chamber. The exemplary illumination system may further include an elongate tubular member extending from a distal end of the body, which may have an illumination path within a lumen of the elongate tubular member, and an illumination source coupled to the illumination path through an optical fiber extending between the body and a surgical console. The exemplary illumination system may include a plurality of illumination controls disposed on the outer surface of the body. A first illumination control may permit the user to selectively control an adjustable illumination level between a high intensity state and a low intensity state.

Abstract: An intraocular pressure (IOP) sensing system may comprise an intraocular pressure sensing implant to be implanted into the eye of a patient for capturing absolute intraocular pressure measurements and an external device for capturing atmospheric pressure measurements. The intraocular pressure sensing implant may be configured to capture an absolute intraocular pressure measurement at an appointed time, and the external device may be configured to capture a plurality of atmospheric pressure measurements around the appointed time.

Abstract: An exemplary illumination system is provided herein for use in performing an ophthalmic surgical procedure. The illumination system may include a body configured to be held by a hand of a user. The body may include an outer surface and an inner surface that defines an inner chamber. The exemplary illumination system may further include an elongate tubular member extending from a distal end of the body, which may have an illumination path within a lumen of the elongate tubular member, and an illumination source coupled to the illumination path through an optical fiber extending between the body and a surgical console. The exemplary illumination system may include a plurality of illumination controls disposed on the outer surface of the body. A first illumination control may permit the user to selectively control an adjustable illumination level between a high intensity state and a low intensity state.

Abstract: A MEMS check valve includes a supporting portion having a first perforation therethrough sized to permit fluid flow and includes a displaceable portion having a second perforation therethrough sized to permit fluid flow. The displaceable portion may be moveable relative to the supporting portion between a closed position inhibiting fluid flow through the valve and an open position permitting fluid flow through the valve. The first and second perforations are offset to inhibit fluid flow when the displaceable portion is in the first position, and fluid may flow through the first and second perforations when the displaceable portion is in the second position.

Abstract: Described herein is an IOP control device for implantation in an eye of a patient, comprising a housing including an inlet port and an outlet port, a fluid flow passageway configured to allow the flow of fluid from the inlet port to the outlet port, and at least one valve anchored within the housing. The at least one valve includes a first side and an opposing second side, and is configured to affect flow through the fluid flow passageway from the inlet port to the outlet port by moving in response to pressure differentials acting on the opposing first and second sides. The at least one valve is remotely adjustable between an active condition increasing resistance to the flow of fluid within the fluid flow passageway and an inactive condition decreasing resistance to the flow of fluid within the fluid flow passageway.

Abstract: Described herein is an IOP control system for implantation in an eye of a patient, comprising a drainage device and a control device. The drainage system includes a housing including an inlet port and an outlet port, a fluid flow passageway extending from the inlet port to the outlet port to allow the flow of fluid therethrough, and at least one valve disposed within the housing. The at least one valve includes a first side and an opposing second side, and is configured to affect flow through the fluid flow passageway from the inlet port to the outlet port by moving in response to pressure differentials acting on the opposing sides. The control device comprises an actuator including an activated mode and a deactivated mode, and the actuator in the activated mode is configured to selectively adjust flow through the drainage device in response to changes in intraocular pressure.

Abstract: Described herein is an IOP control device for implantation in an eye of a patient, comprising a housing including an inlet port and an outlet port, a fluid flow passageway configured to allow the flow of fluid from the inlet port to the outlet port, and at least one valve anchored within the housing. The at least one valve includes a first side and an opposing second side, and is configured to affect flow through the fluid flow passageway from the inlet port to the outlet port by moving in response to pressure differentials acting on the opposing first and second sides. The at least one valve is remotely adjustable between an active condition increasing resistance to the flow of fluid within the fluid flow passageway and an inactive condition decreasing resistance to the flow of fluid within the fluid flow passageway.

Abstract: Described herein is an IOP control system for implantation in an eye of a patient, comprising a drainage device and a control device. The drainage system includes a housing including an inlet port and an outlet port, a fluid flow passageway extending from the inlet port to the outlet port to allow the flow of fluid therethrough, and at least one valve disposed within the housing. The at least one valve includes a first side and an opposing second side, and is configured to affect flow through the fluid flow passageway from the inlet port to the outlet port by moving in response to pressure differentials acting on the opposing sides. The control device comprises an actuator including an activated mode and a deactivated mode, and the actuator in the activated mode is configured to selectively adjust flow through the drainage device in response to changes in intraocular pressure.

Abstract: In various embodiments, an ophthalmic injection device may include a dispensing chamber, a first thermal sensor coupled to the dispensing chamber, a temperature control layer coupled to the dispensing chamber, a second thermal sensor coupled to the dispensing chamber, and a first processing device. The first processing device may be configured to receive temperature information from the first thermal sensor and the second thermal sensor and control the temperature control layer using the received temperature information. In some embodiments, the first processing device may receive temperature information directly from the second thermal sensor (e.g., in analog form) and may compare the temperature information from the first thermal sensor (e.g., received from the second processing device in digital form) and the second thermal sensor to detect temperature offsets between the two sensors.

Abstract: In various embodiments, an ophthalmic injection device may include a dispensing chamber to hold a substance (e.g., a drug) to be injected into an eye, a thermal feedback layer with at least one thermal sensor, and a temperature control layer to apply or remove heat from the dispensing chamber. In some embodiments, the thermal feedback layer and the temperature control layer may be coupled to each other and/or coupled to the dispensing chamber. In some embodiments, at least one of the thermal sensors may be secured between the temperature control layer and the dispensing chamber using a thermal adhesive.

Abstract: In various embodiments, an ophthalmic injection device may include a dispensing chamber, a first thermal sensor coupled to the dispensing chamber, a temperature control layer coupled to the dispensing chamber, a second thermal sensor coupled to the dispensing chamber, and a first processing device. The first processing device may be configured to receive temperature information from the first thermal sensor and the second thermal sensor and control the temperature control layer using the received temperature information. In some embodiments, the first processing device may receive temperature information directly from the second thermal sensor (e.g., in analog form) and may compare the temperature information from the first thermal sensor (e.g., received from the second processing device in digital form) and the second thermal sensor to detect temperature offsets between the two sensors.

Abstract: In various embodiments, an ophthalmic injection device may include a dispensing chamber to hold a substance (e.g., a drug) to be injected into an eye, a thermal feedback layer with at least one thermal sensor, and a temperature control layer to apply or remove heat from the dispensing chamber. In some embodiments, the thermal feedback layer and the temperature control layer may be coupled to each other and/or coupled to the dispensing chamber. In some embodiments, at least one of the thermal sensors may be secured between the temperature control layer and the dispensing chamber using a thermal adhesive.

Abstract: A method of injecting a mixture into an eye includes: providing the mixture in a dispensing chamber with an air gap located between the mixture and an interior surface of a dispensing chamber housing, when the mixture and dispensing chamber housing are near room temperature; bringing the dispensing chamber housing and mixture to a temperature range, other than near room temperature, at which the mixture expands and is in a more liquid state; maintaining air in a needle after the mixture expands and prior to an injection; selecting a drug release rate; and injecting the mixture so as to form a shape with a surface area that results in the selected drug release rate.

Abstract: A method of injecting a mixture into an eye includes: providing the mixture in a dispensing chamber with an air gap located between the mixture and an interior surface of a dispensing chamber housing, when the mixture and dispensing chamber housing are near room temperature; bringing the dispensing chamber housing and mixture to a temperature range at which the mixture expands and is in a more liquid state; maintaining air in a needle after the mixture expands and prior to an injection; and injecting the air in the needle and the mixture into the eye.