Patents by Inventor Cesear Corona
Cesear Corona has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250215473Abstract: Examples are directed to photothermal nanoparticles, devices, and kits thereof. An example photothermal nanoparticle, which may form part of a device and/or kit, has a particular geometric shape and comprising a single component nanoparticle or a multi-component nanoparticle, wherein the photothermal nanoparticle is further categorized by surface plasmon resonance with a resonance wavelength in a particular range to convert energy absorbed from a light source to heat, and wherein the particular geometric shape is selected from the group consisting of: polyhedral, spheroid, torus, and hollow shapes.Type: ApplicationFiled: February 17, 2025Publication date: July 3, 2025Applicant: Promega CorporationInventors: Zhiyang Zeng, Maria Perez Cardenas, Cesear Corona, Wenhui Zhou, Poncho Meisenheimer, Doug Storts, Andrew Taft
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Patent number: 12227781Abstract: Methods using photothermal nanoparticles in rapid nucleic acid amplification and photothermal nanoparticles include forming a reaction mixture comprising a nucleic acid template, a polymerase enzyme, and a heating media. The heating media comprises a plurality of photothermal nanoparticles suspended in a solution, fabricated on a microchip, or on a surface of a well in a multi-well plate. The photothermal nanoparticles are nanoparticles having a particular geometric shape and comprise a single component or a multi-component. The plurality of photothermal nanoparticles are further categorized by surface plasmon resonance with a resonance wavelength in a particular range to convert energy absorbed from a light source to sufficiently heat a volume of a composition for the transcription of the new nucleic acid strand. The particular geometric shape of the photothermal nanoparticles is selected from the group consisting of: polyhedral, spheroid, torus, and hollow shapes.Type: GrantFiled: May 21, 2020Date of Patent: February 18, 2025Assignee: Promega CorporationInventors: Zhiyang Zeng, Maria Perez Cardenas, Cesear Corona, Wenhui Zhou, Poncho Meisenheimer, Doug Storts, Andrew Taft
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Publication number: 20250003974Abstract: The present invention provides compounds and methods of use thereof for assessing target engagement for DNA polymerase theta. In particular, provided herein are tracer compounds comprising a small molecule that binds DNA polymerase theta tethered to a fluorophore, and methods of use thereof in target engagement assays.Type: ApplicationFiled: June 21, 2024Publication date: January 2, 2025Inventors: Michael Slater, James Vasta, Mathew Robers, Matthew Larsen, Cesear Corona, Weiwei An, Min Zhou, Wenhui Zhou
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Patent number: 12078634Abstract: Provided herein are compounds that are broad-spectrum protein kinase binding agents, detectable tracers comprising such compounds, and method of use thereof for the detection of protein kinases.Type: GrantFiled: August 15, 2022Date of Patent: September 3, 2024Assignee: Promega CorporationInventors: Cesear Corona, Poncho Meisenheimer, Matthew Robers, James Vasta
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Publication number: 20230194515Abstract: Provided herein are compounds that are broad-spectrum protein kinase binding agents, detectable tracers comprising such compounds, and method of use thereof for the detection of protein kinases.Type: ApplicationFiled: August 15, 2022Publication date: June 22, 2023Inventors: Cesear Corona, Poncho Meisenheimer, Matthew Robers, James Vasta
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Patent number: 11442063Abstract: Provided herein are compounds that are broad-spectrum protein kinase binding agents, detectable tracers comprising such compounds, and method of use thereof for the detection of protein kinases.Type: GrantFiled: May 30, 2019Date of Patent: September 13, 2022Assignee: Promega CorporationInventors: Cesear Corona, Poncho Meisenheimer, Matthew Robers, James Vasta
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Publication number: 20220064696Abstract: Provided herein are systems, methods, and compounds for identifying RAS binding compounds using a RAS binding agent, which comprises a RAS binding moiety and a functional element. In some embodiments, the RAS binding agent binds to one site on the RAS protein (e.g., KRAS, HRAS, or NRAS), and can be used to detect RAS binding agents that bind to the same site as well as other sites.Type: ApplicationFiled: August 27, 2021Publication date: March 3, 2022Applicant: Promega CorporationInventors: Matthew B. Robers, Joel R. Walker, James Vasta, Cesear Corona
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Publication number: 20200370083Abstract: Methods using photothermal nanoparticles in rapid nucleic acid amplification and photothermal nanoparticles include forming a reaction mixture comprising a nucleic acid template, a polymerase enzyme, and a heating media. The heating media comprises a plurality of photothermal nanoparticles suspended in a solution, fabricated on a microchip, or on a surface of a well in a multi-well plate. The photothermal nanoparticles are nanoparticles having a particular geometric shape and comprise a single component or a multi-component. The plurality of photothermal nanoparticles are further categorized by surface plasmon resonance with a resonance wavelength in a particular range to convert energy absorbed from a light source to sufficiently heat a volume of a composition for the transcription of the new nucleic acid strand. The particular geometric shape of the photothermal nanoparticles is selected from the group consisting of: polyhedral, spheroid, torus, and hollow shapes.Type: ApplicationFiled: May 21, 2020Publication date: November 26, 2020Inventors: Zhiyang Zeng, Maria Perez Cardenas, Cesear Corona, Wenhui Zhou, Poncho Meisenheimer, Doug Storts, Andrew Taft
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Publication number: 20200003771Abstract: Provided herein are compounds that are broad-spectrum protein kinase binding agents, detectable tracers comprising such compounds, and method of use thereof for the detection of protein kinases.Type: ApplicationFiled: May 30, 2019Publication date: January 2, 2020Inventors: Cesear Corona, Poncho Meisenheimer, Matthew Robers, James Vasta
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Patent number: 9702824Abstract: Provided herein are fluorescent sensor agents, and methods of use and manufacture thereof. In particular, sensor agents are provided that exhibit a detectable change in fluorescence (e.g., fluorescence intensity) upon alteration of the pH of the surrounding environment (e.g., upon moving from one pH environment to another).Type: GrantFiled: March 8, 2013Date of Patent: July 11, 2017Assignee: PROMEGA CORPORATIONInventors: Mei Cong, Cesear Corona, Mark G. McDougall, Chad Zimprich
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Publication number: 20150044776Abstract: Provided herein are fluorescent sensor agents, and methods of use and manufacture thereof. In particular, sensor agents are provided that exhibit a detectable change in fluorescence (e.g., fluorescence intensity) upon alteration of the pH of the surrounding environment (e.g., upon moving from one pH environment to another).Type: ApplicationFiled: March 8, 2013Publication date: February 12, 2015Applicant: PROMEGA CORPORATIONInventors: Mei Cong, Cesear Corona, Mark G. McDougall, Chad Zimprich
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Patent number: 8309059Abstract: The invention provides compounds and compositions of Formulas I-VII, and methods of using the compounds. The compounds can be used to prepare dye conjugates that are uniformly and substantially more fluorescent on proteins, nucleic acids or other biopolymers, than conjugates labeled with structurally similar known carbocyanine dyes. In addition to having more intense fluorescence emission than structurally similar dyes at virtually identical wavelengths, and decreased artifacts in their absorption spectra upon conjugation to biopolymers, the compounds can have greater photostability and/or higher absorbance (extinction coefficients) at the wavelength(s) of peak absorbance than such structurally similar dyes.Type: GrantFiled: August 31, 2010Date of Patent: November 13, 2012Assignee: Promega CorporationInventors: Cesear Corona, Dieter Klaubert, Mark McDougall
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Patent number: 8288559Abstract: Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions.Type: GrantFiled: August 18, 2009Date of Patent: October 16, 2012Assignee: Promega CorporationInventors: Cesear Corona, Poncho Meisenheimer, Harry Tetsuo Uyeda
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Publication number: 20110053162Abstract: The invention provides compounds and compositions of Formulas I-VII, and methods of using the compounds. The compounds can be used to prepare dye conjugates that are uniformly and substantially more fluorescent on proteins, nucleic acids or other biopolymers, than conjugates labeled with structurally similar known carbocyanine dyes. In addition to having more intense fluorescence emission than structurally similar dyes at virtually identical wavelengths, and decreased artifacts in their absorption spectra upon conjugation to biopolymers, the compounds can have greater photostability and/or higher absorbance (extinction coefficients) at the wavelength(s) of peak absorbance than such structurally similar dyes.Type: ApplicationFiled: August 31, 2010Publication date: March 3, 2011Applicant: PROMEGA CORPORATIONInventors: Cesear Corona, Dieter Klaubert, Mark McDougall
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Publication number: 20100062470Abstract: Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions.Type: ApplicationFiled: August 18, 2009Publication date: March 11, 2010Applicant: Promega CorporationInventors: Cesear Corona, Poncho Meisenheimer, Harry Tetsuo Uyeda