Abstract: A method, device and system for ultrasonic delivery and attachment of ligand-receptor based drugs and/or drug carriers and/or image enhancing contrast agents utilizing catch and slip bond mechanisms in a targeted part(s) of the human or animal (patient) body or organs or tissue is described and disclosed. The system includes an acoustic power source coupled to an acoustic transducer with the acoustic transducer placed upon a patient's delivery zone. The acoustic transducer transmits an acoustic field to the target drug delivery and/or imaging zone. A detection probe and/or a probe of an imaging system are placed over or within said delivery zone and the probe is coupled to a sensing/imaging system. A control computer that controls power and wave shape of the acoustic signal generated into the acoustic filed by the acoustic power source and receives data from the sensing/imaging system.

Abstract: A set of multi-mode elastic wave generating and detecting devices and field sensors are utilized in a real-time in-situ monitoring system based on the quality assessment of a specially designed article made by an additive manufacturing machine. The original invention disclosed in U.S. patent application Ser. No. 15/731,366 involves the transmission and reception of waves into a periodic test artifact while it is being built. The current invention involves the transmission and reception of multi-mode waves into a test artifact, the processing of data from narrow and wide field-of-view sensors, and correlating and relating the waveforms and sensor data while it is being built using physics-based and machine learning models. The disclosed system may initiate control and real-time corrective actions based on the properties and characteristics of the obtained waveforms and sensor data and their correlations and functional relationships.

Abstract: An in-process real-time method, system and device is provided for monitoring the quality of an article made by additive manufacturing processes. The invention involves the transmission and reception of waves into a test artifact while it is being built. The properties of received waves depend on the parameters of the additive manufacturing process, the properties of materials involved, and their irregularities as well as geometric deviations, as its structural periodicity and defects leads to the dispersion of waves. Based on the features of the artifact, the test artifact is designed to capture deviations in all or a sub-set of process, material, and geometric parameters. A computing device in communications with operators, the control unit of the additive manufacturing machine and other computing facilities is used for creating and analyzing waveforms. The disclosed system may initiate real-time actions based on the properties of the obtained waveforms.

Abstract: A solid dosage product having a tailored dissolution profile comprises a carrier block defining a plurality of compartments where each respective compartment is configured to receive one or more active pharmaceutical ingredient and the carrier block being digestible within an animal such that each respective active pharmaceutical ingredient is controllably released; and one or more coating layers applied to the carrier block. A method for manufacturing a solid dosage product having a tailored dissolution comprises manufacturing a digestible carrier block where the carrier block defines a plurality of compartments with each respective compartment configured to receive an active pharmaceutical ingredient; filling a respective compartment with a respective active pharmaceutical ingredient; and coating the carrier block with one or more coating layers.

Abstract: A solid dosage product having a tailored dissolution profile comprises a carrier block defining a plurality of compartments where each respective compartment is configured to receive one or more active pharmaceutical ingredient and the carrier block being digestible within an animal such that each respective active pharmaceutical ingredient is controllably released; and one or more coating layers applied to the carrier block. A method for manufacturing a solid dosage product having a tailored dissolution comprises manufacturing a digestible carrier block where the carrier block defines a plurality of compartments with each respective compartment configured to receive an active pharmaceutical ingredient; filling a respective compartment with a respective active pharmaceutical ingredient; and coating the carrier block with one or more coating layers.

Abstract: The present invention relates to a methods and systems for monitoring and/or characterizing multi-component tablets and for monitoring punch and die surfaces and, more particularly, to methods and systems for in-die and out-of-die monitoring and/or characterizing multi-component tablets based on acoustic and vibrational spectroscopy and for detecting and monitoring stiction and tooling material modifications on punch and die surfaces during compaction based on acoustic/ultrasonic waves.

Abstract: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontroller(s) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto.

Abstract: The present invention relates to methods and systems for condition monitoring of and/or fault diagnostics in solid dosage compaction presses and, more particularly, to methods and systems for real-time vibroacoustic condition monitoring of and/or fault diagnostics in solid dosage compaction presses.

Abstract: The present invention relates to a methods and systems for monitoring and/or characterizing multi-component tablets and for monitoring punch and die surfaces and, more particularly, to methods and systems for in-die and out-of-die monitoring and/or characterizing multi-component tablets based on acoustic and vibrational spectroscopy and for detecting and monitoring stiction and tooling material modifications on punch and die surfaces during compaction based on acoustic/ultrasonic waves.

Abstract: The present invention relates to a methods and systems for monitoring and/or characterizing multi-component tablets and for monitoring punch and die surfaces and, more particularly, to methods and systems for in-die and out-of-die monitoring and/or characterizing multi-component tablets based on acoustic and vibrational spectroscopy and for detecting and monitoring stiction and tooling material modifications on punch and die surfaces during compaction based on acoustic/ultrasonic waves.

Abstract: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontroller(s) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto.

Abstract: The present invention relates to methods and systems for condition monitoring of and/or fault diagnostics in solid dosage compaction presses and, more particularly, to methods and systems for real-time vibroacoustic condition monitoring of and/or fault diagnostics in solid dosage compaction presses.

Abstract: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto.

Abstract: The present invention relates to a methods and systems for monitoring and/or characterizing multi-component tablets and for monitoring punch and die surfaces and, more particularly, to methods and systems for in-die and out-of-die monitoring and/or characterizing multi-component tablets based on acoustic and vibrational spectroscopy and for detecting and monitoring stiction and tooling material modifications on punch and die surfaces during compaction based on acoustic/ultrasonic waves.

Abstract: A non-contact/non-destructive technique for determining the mechanical properties of coated drug tablets is presented. One method is to detect, monitor and characterize a drug tablet during compaction by means of transmitting and receiving acoustic waves into the powder core, as it is formed in a press (compactor), via transducers embedded in the compactor die and punches. An iterative computational procedure is shown that extracts the mechanical properties of the coated tablet from a subset of its measured resonance frequencies. Sensitivities of the resonance frequencies to changes in the tablet mechanical properties is illustrated and discussed. These non-destructive techniques require no physical contact with the tablet and operate in the microsecond time-scale. Therefore, they can be employed for rapid monitoring and characterization applications.

Abstract: A system, method and device for measuring toner performance by randomly applying a toner sample having toner particles to a substrate, and positioning the substrate such that a force may be applied to individual particles of the measuring toner. A rolling resistance or rotation of the individual particles of the measuring toner is measured. The measurements may be analyzed to determine adhesion and distribution properties of individual toner particles of the measuring toner sample.

Abstract: A system, method and device for measuring toner performance by randomly applying a toner sample having toner particles to a substrate, and positioning the substrate such that a force may be applied to individual particles of the measuring toner. A rolling resistance or rotation of the individual particles of the measuring toner is measured. The measurements may be analyzed to determine adhesion and distribution properties of individual toner particles of the measuring toner sample.

Abstract: The present invention relates to a method and apparatus for real-time monitoring and controlling surface area erosion of a sputter target assembly utilized in a physical vapor deposition process.

Abstract: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto.

Abstract: The present invention relates to a method and apparatus for real-time monitoring and controlling surface area erosion of a sputter target assembly utilized in a physical vapor deposition process.