Patents by Inventor Chad A. Haraldson
Chad A. Haraldson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10766896Abstract: Imidazo[4,5-c] ring compounds of formula I, (particularly imidazo4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridine compounds) having a guanidine substituted benzamide that is attached at the N?1 position by a linking group, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are also disclosed.Type: GrantFiled: February 27, 2018Date of Patent: September 8, 2020Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventors: Bryon A. Merrill, George W. Griesgraber, Chad A. Haraldson, Kevin J. Bechtold
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Publication number: 20200087298Abstract: Imidazo[4,5-c] ring compounds of formula I, (particularly imidazo4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridine compounds) having a guanidine substituted benzamide that is attached at the N?1 position by a linking group, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are also disclosed.Type: ApplicationFiled: February 27, 2018Publication date: March 19, 2020Inventors: Bryon A. Merrill, George W. Griesgraber, Chad A. Haraldson, Kevin J. Bechtold
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Patent number: 10035909Abstract: Compositions comprising surface-modified calcite nanoparticles dispersed in a curable resin and to coatings and fibrous composites incorporating such compositions are described. The nanocalcite particles have a high magnesium to calcium surface concentration ratio. The surface-modifying agents include a binding group ionically associated with the nanoparticles, and a compatiblizing segment compatible with the curable resin. The surface-modifying agent may also include a reactive group capable of reacting with the curable resin. Methods of preparing nanocalcite composites, and coatings and fibrous composites prepared from such nanocalcite composites are also described.Type: GrantFiled: December 17, 2009Date of Patent: July 31, 2018Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventors: William J. Schultz, Mary I. Buckett, Peter D. Condo, Douglas P. Goetz, Chad A. Haraldson, Mark McCormick, Wendy L. Thompson, Steven J. Pachuta
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Patent number: 10023726Abstract: Compositions comprising surface-modified nanocalcite particles dispersed in a curable resin system comprising a vinyl ester, and coatings and fibrous composites incorporating such compositions are described. The surface-modifying agents include a binding group ionically associated with the calcite and a compatiblizing segment, compatible with the curable resin. The surface-modifying agent may also include a reactive group capable of reacting with the curable resin system. Methods of preparing nanocalcite composites and coating a fibrous composites prepared from such nanocalcite composites are also described.Type: GrantFiled: December 13, 2010Date of Patent: July 17, 2018Assignee: 3M Innovative Properties CompanyInventors: William J. Schultz, Peter D. Condo, Emily S. Goenner, Chad A. Haraldson
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Patent number: 9856254Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.Type: GrantFiled: June 13, 2016Date of Patent: January 2, 2018Assignee: 3M Innovative Properties CompanyInventors: Kyle J. Lindstrom, Bryon A. Merrill, Chad A. Haraldson, Michael J. Rice, Tushar A. Kshirsagar, Philip D. Heppner, Joshua R. Wurst, Shri Niwas, Sarah J. Slania
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Patent number: 9783681Abstract: Methods of compounding nanoparticles with a resin, e.g., a curable resin and one or more surface modifying agents are described. The methods use wet milling technology, including both continuous and batch milling processes, and can be used to functionalize the nanoparticles and disperse the functionalized nanoparticles into the resin system in a single process. Methods of compounding curable resin systems containing reactive diluents are also disclosed.Type: GrantFiled: October 21, 2010Date of Patent: October 10, 2017Assignee: 3M Innovative Properties CompanyInventors: Peter D. Condo, Jung-Sheng Wu, Chad A. Haraldson, William J. Schultz, Emily S. Goenner, James E. Thorson, Wendy L. Thompson
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Patent number: 9512264Abstract: Nanoparticle compositions including calcite and a surface-modifying agent bonded to the calcite are described. The surface-modifying agent includes a binding group bonded to the calcite and a compatiblizing segment. The compatiblizing segment includes at least one of a polyethylene oxide, a polypropylene oxide, a polyester, a polyamide, or a combination thereof. The composition includes less than 2 wt. % solvents and/or resins. Methods of preparing nanoparticle compositions are also described.Type: GrantFiled: December 12, 2011Date of Patent: December 6, 2016Assignee: 3M Innovative Properties CompanyInventors: Peter D. Condo, William J. Schultz, Chad A. Haraldson, Jung-Sheng Wu
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Publication number: 20160280707Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.Type: ApplicationFiled: June 13, 2016Publication date: September 29, 2016Inventors: Kyle J. Lindstrom, Bryon A. Merrill, Chad A. Haraldson, Michael J. Rice, Tushar A. Kshirsagar, Philip D. Heppner, Joshua R. Wurst, Shri Niwas, Sarah J. Slania
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Patent number: 9365567Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.Type: GrantFiled: September 30, 2014Date of Patent: June 14, 2016Assignee: 3M Innovative Properties CompanyInventors: Kyle J. Lindstrom, Bryon A. Merrill, Chad A. Haraldson, Michael J. Rice, Tushar A. Kshirsagar, Philip D. Heppner, Joshua R. Wurst, Shri Niwas, Sarah J. Slania
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Patent number: 9221970Abstract: Compositions comprising surface-modified nanocalcite particles dispersed in a curable resin, and to coatings and fibrous composites incorporating such compositions are described. The surface-modifying agents include a binding group ionically associated with the calcite and a compatiblizing segment, compatible with the curable resin. The surface-modifying agent may also include a reactive group capable of reacting with the curable resin. Methods of preparing nanocalcite composites and coating a fibrous composites prepared from such nanocalcite composites are also described.Type: GrantFiled: December 17, 2009Date of Patent: December 29, 2015Assignee: 3M Innovative Properties CompanyInventors: William J. Schultz, Chad A. Haraldson, Nathan E. Schultz, Wendy L. Thompson, James E. Thorson, Douglas P. Goetz, Steven C. Hackett, James M. Nelson
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Publication number: 20150023990Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.Type: ApplicationFiled: September 30, 2014Publication date: January 22, 2015Inventors: Kyle J. Lindstrom, Bryon A. Merrill, Chad A. Haraldson, Michael J. Rice, Tushar A. Kshirsagar, Philip D. Heppner, Joshua R. Wurst, Shri Niwas, Sarah J. Slania
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Patent number: 8871782Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.Type: GrantFiled: October 1, 2004Date of Patent: October 28, 2014Assignee: 3M Innovative Properties CompanyInventors: Kyle J. Lindstrom, Bryon A. Merrill, Chad A. Haraldson, Michael J. Rice, Tushar A. Kshirsagar, Philip D. Heppner, Joshua R. Wurst, Shri Niwas, Sarah C. Johannessen
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Patent number: 8658666Abstract: Imidazoquinolines and imidazonaphthyridines with a substituent containing a functional group, e.g., an amide, sulfonamide, urea, or heterocyclyl group, at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.Type: GrantFiled: February 10, 2006Date of Patent: February 25, 2014Assignee: 3M Innovative Properties CompanyInventors: Michael J. Rice, Chad A. Haraldson, John F. Gerster, Joshua R. Wurst, Philip D. Heppner, Bryon A. Merrill, Tushar A. Kshirsagar
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Publication number: 20130253139Abstract: Nanoparticle compositions including calcite and a surface-modifying agent bonded to the calcite are described. The surface-modifying agent includes a binding group bonded to the calcite and a compatiblizing segment. The compatiblizing segment includes at least one of a polyethylene oxide, a polypropylene oxide, a polyester, a polyamide, or a combination thereof. The composition includes less than 2 wt. % solvents and/or resins. Methods of preparing nanoparticle compositions are also described.Type: ApplicationFiled: December 12, 2011Publication date: September 26, 2013Applicant: eM Innovative Properties CompanyInventors: Peter D. Condo, William J. Schultz, Chad A. Haraldson, Jung-Sheng Wu
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Publication number: 20120244338Abstract: Compositions comprising surface-modified nanocalcite particles dispersed in a curable resin system comprising a vinyl ester, and coatings and fibrous composites incorporating such compositions are described. The surface-modifying agents include a binding group ionically associated with the calcite and a compatiblizing segment, compatible with the curable resin. The surface-modifying agent may also include a reactive group capable of reacting with the curable resin system. Methods of preparing nanocalcite composites and coating a fibrous composites prepared from such nanocalcite composites are also described.Type: ApplicationFiled: December 13, 2010Publication date: September 27, 2012Inventors: William J. Schultz, Peter D. Condo, Emily S. Goenner, Chad A. Haraldson
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Publication number: 20120245253Abstract: Compositions comprising surface-modified calcite nanoparticles dispersed in a curable resin and to coatings and fibrous composites incorporating such compositions are described. The nanocalcite particles have a high magnesium to calcium surface concentration ratio. The surface-modifying agents include a binding group ionically associated with the nanoparticles, and a compatiblizing segment compatible with the curable resin. The surface-modifying agent may also include a reactive group capable of reacting with the curable resin. Methods of preparing nanocalcite composites, and coatings and fibrous composites prepared from such nanocalcite composites are also described.Type: ApplicationFiled: December 17, 2009Publication date: September 27, 2012Inventors: William J. Schultz, Mary I. Buckett, Peter D. Condo, Douglas P. Goetz, Chad A. Haraldson, Mark McCormick, Wendy L. Thompson, Steven J. Pachuta
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Patent number: 8263594Abstract: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.Type: GrantFiled: January 18, 2011Date of Patent: September 11, 2012Assignee: 3M Innovative Properties CompanyInventors: Kyle J. Lindstrom, Hugues M. H. Martin, Bryon A. Merrill, Michael J. Rice, Joshua R. Wurst, Chad A. Haraldson, Philip D. Heppner, Shri Niwas, Matthew R. Radmer
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Publication number: 20120214948Abstract: Methods of compounding nanoparticles with a resin, e.g., a curable resin and one or more surface modifying agents are described. The methods use wet milling technology, including both continuous and batch milling processes, and can be used to functionalize the nanoparticles and disperse the functionalized nanoparticles into the resin system in a single process. Methods of compounding curable resin systems containing reactive diluents are also disclosed.Type: ApplicationFiled: October 21, 2010Publication date: August 23, 2012Inventors: Peter D. Condo, Jung-Sheng Wu, Chad A. Haraldson, William J. Schultz, Emily S. Goenner, James E. Thorson, Wendy L. Thompson
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Publication number: 20110245376Abstract: Compositions comprising surface-modified nanocalcite particles dispersed in a curable resin, and to coatings and fibrous composites incorporating such compositions are described. The surface-modifying agents include a binding group ionically associated with the calcite and a compatiblizing segment, compatible with the curable resin. The surface-modifying agent may also include a reactive group capable of reacting with the curable resin. Methods of preparing nanocalcite composites and coating a fibrous composites prepared from such nanocalcite composites are also described.Type: ApplicationFiled: December 17, 2009Publication date: October 6, 2011Inventors: William J. Schultz, Chad A. Haraldson, Nathan E. Schultz, Wendy L. Thompson, James E. Thorson, Douglas P. Goetz, Steven C. Hackett, James M. Nelson
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Patent number: 8017779Abstract: Imidazoquinoline and imidazonaphthyridine compounds having a nitrogen-containing heterocyclyl substituent at the 5-, 6-, 7-, or 8-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.Type: GrantFiled: June 15, 2005Date of Patent: September 13, 2011Assignee: 3M Innovative Properties CompanyInventors: Bryon A. Merrill, Chad A. Haraldson, Tushar A. Kshirsagar, Shri Niwas