Patents by Inventor Chad A. Mirkin

Chad A. Mirkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10328026
    Abstract: Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may be surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: June 25, 2019
    Assignee: Northwestern University
    Inventors: C. Shad Thaxton, Chad A. Mirkin, Kaylin M. McMahon, Sushant Tripathy, Raja Kannan Mutharasan, David M. Leander, Andrea Luthi
  • Publication number: 20190160733
    Abstract: Methods and apparatus comprising a dewetting phase and a polymerization liquid that are immiscible, and can be used for the formation of three-dimensional objects, wherein the method does not require a dead zone. Additionally, methods and apparatus that employ an optically transparent cooling apparatus to mitigate heat generated during the fabrication process, and the use of a mobile phase to provide a shearing interface to reduce interfacial adhesive forces.
    Type: Application
    Filed: May 31, 2017
    Publication date: May 30, 2019
    Inventors: Chad A. Mirkin, David A. Walker, James L. Hedrick, III
  • Patent number: 10301622
    Abstract: The present invention relates to methods of detecting and tracking a target molecule using a nanoparticle wherein the nanoparticle comprises a polynucleotide that can specifically associate with the target molecule, and wherein the association results in a change in a detectable marker that can be measured after association with the target molecule.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: May 28, 2019
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, William E. Briley, Pratik S. Randeria, Nathaniel J. Kim
  • Patent number: 10222694
    Abstract: The disclosure relates to methods of printing indicia on a substrate using a tip array comprised of elastomeric, compressible polymers. The tip array can be prepared using conventional photolithographic methods and can be tailored to have any desired number and/or arrangement of tips. Numerous copies (e.g., greater than 15,000, or greater than 11 million) of a pattern can be made in a parallel fashion in as little as 40 minutes.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: March 5, 2019
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, Fengwei Huo, Zijian Zheng, Gengfeng Zheng
  • Patent number: 10203598
    Abstract: The disclosure provides a method of inking a polymer pen lithography tip array (“PPL tip array”), including applying an ink composition to a PPL tip array using at least two spray applicators to deposit the ink as a non-uniform ink layer. The disclosure further provides a method of depositing at least two ink compositions on PPL tip array, including applying a first ink to a first defined area using a first spray applicator, and applying a second ink to a second defined area using a second spray applicator. The disclosure further provides a method of scaling a linear ink composition gradient provided by at least two spray applicators to a PPL tip array having a length, L, including positioning the spray applicators at a distance of about 5.0 L to about 8.0 L relative to the surface of the PPL tip array, positioning the spray applicators at a distance of about 0.5 L to about 3.0 L relative to each other, and applying an ink composition.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: February 12, 2019
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, Keith A. Brown, James L. Hedrick, III
  • Publication number: 20190030185
    Abstract: The present invention relates to compositions and methods for delivering an oligonucleotide-functionalized nanoparticle.
    Type: Application
    Filed: October 15, 2018
    Publication date: January 31, 2019
    Inventors: Chad A. Mirkin, Amy S. Paller, David A. Giljohann
  • Patent number: 10182988
    Abstract: Liposomes termed as small unilamellar vesicles (SUVs), can be synthesized in the 20-50 nm size range, but encounter challenges such as instability and aggregation leading to inter-particle fusion. This limits their use as a therapeutic delivery agent. Increasing the surface negative charge of SUVs, via the attachment of anionic entities such as DNA/RNA, increases the colloidal stability of these vesicles. Additionally, the dense spherical arrangement and radial orientation of nucleic acids exhibits unique chemical and biological properties, unlike their linear counterparts. These liposomal particles, are non-toxic and though anionic, can efficiently enter cells without the aid of ancillary cationic transfection agents in a non-immunogenic fashion. These exceptional properties allow their use as delivery agents for gene regulation in different therapies and offer an alternative platform to metal core spherical nucleic acids.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: January 22, 2019
    Assignees: NORTHWESTERN UNIVERSITY, EXICURE, INC.
    Inventors: Chad A. Mirkin, Sonbinh T. Nguyen, Resham Singh Banga, Natalia Chernyak, Sergei Gryaznov, Aleksandar Radovic-Moreno, Christopher Mader
  • Publication number: 20180344873
    Abstract: Spherical nucleic acids (SNAs), consisting of densely packed, highly oriented polynucleotide strands attached to the surface of nanoparticles, are able to overcome the typical challenges of nucleic acid delivery. The present disclosure demonstrates that G-rich SNAs exhibit several-fold higher uptake into cells relative to SNAs rich in other nucleotides. This disclosure provides an effective strategy to maximize the intracellular delivery of SNAs, which is applicable to other nanoparticle systems, thus establishing an important design consideration for nanoparticle-based intracellular delivery of therapeutics.
    Type: Application
    Filed: November 20, 2015
    Publication date: December 6, 2018
    Inventors: Chad A. Mirkin, Chung Hang J. Choi, Sunguna P. Narayan, Liangliang Hao, Evelyn Auyeung
  • Patent number: 10098958
    Abstract: The present invention relates to compositions and methods for delivering an oligonucleotide-functionalized nanoparticle.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: October 16, 2018
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, Amy S. Paller, David A. Giljohann
  • Publication number: 20180238889
    Abstract: The disclosure relates to the identification of a novel molecular signature based on the differential expression of circulating microRNAs (miRNA) in serum samples specific to patients with clinically significant diseases or disorders, such as cancer.
    Type: Application
    Filed: August 15, 2016
    Publication date: August 23, 2018
    Inventors: Chad A. Mirkin, Joshua J. Meeks, C. Shad Thaxton, Ali Alhasan
  • Publication number: 20180193484
    Abstract: Polyvalent nanoconjugates address the critical challenges in therapeutic use. The single-entity, targeted therapeutic is able to cross the blood-brain barrier (BBB) and is thus effective in the treatment of central nervous system (CNS) disorders. Further, despite the tremendously high cellular uptake of nanoconjugates, they exhibit no toxicity in the cell types tested thus far. This property is critical for therapeutic agent delivery applications for reducing off-target effects.
    Type: Application
    Filed: December 29, 2017
    Publication date: July 12, 2018
    Inventors: Chad A. Mirkin, Caroline H. Ko, David A. Giljohann, Janina Luciano, Samuel A. Jensen, Alexander Stegh
  • Publication number: 20180187189
    Abstract: Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.
    Type: Application
    Filed: July 19, 2017
    Publication date: July 5, 2018
    Inventors: Chad A. Mirkin, Nathaniel L. Rosi, C. Shad Thaxton, David A. Giljohann
  • Patent number: 9969759
    Abstract: Disclosed herein are organometallic complexes and methods of using the same in detecting double stranded DNA or RNA, selectively over single stranded DNA or RNA.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: May 15, 2018
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, Chad M. Shade, Robert D. Kennedy, Jessica Lynn Rouge, Soyoung E. Seo, Mary X. Wang
  • Patent number: 9971239
    Abstract: Provided here are hard transparent polymer pen arrays, methods of printing indicia using the same, and methods of preparing the same.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: May 15, 2018
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, Keith A. Brown, James L. Hedrick, III
  • Publication number: 20180117175
    Abstract: The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.
    Type: Application
    Filed: August 30, 2017
    Publication date: May 3, 2018
    Inventors: Chad A. Mirkin, David A. Giljohann, Weston L. Daniel, Joshua I. Cutler, Ke Zhang, Dan Zheng
  • Publication number: 20180085390
    Abstract: The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating RNA to a nanoparticle to achieve increased stability and activity.
    Type: Application
    Filed: November 10, 2017
    Publication date: March 29, 2018
    Inventors: Chad A. Mirkin, David A. Giljohann, Dwight S. Seferos, Andrew E. Prigodich, Pinal C. Patel
  • Publication number: 20180080058
    Abstract: The present disclosure provides methods in which adherent cells are treated with small molecules, cultured, lysed, and then analyzed by mass spectrometry to measure the activities of endogenous enzymes. The implementation of this method relies on the use of surfaces that are nanopatterned with cell adhesion ligands to mediate cell attachment and a peptide that is a substrate for the desired enzyme activity in the lysate.
    Type: Application
    Filed: September 20, 2017
    Publication date: March 22, 2018
    Inventors: Milan Mrksich, Maria D. Cebezas, Chad A. Mirkin
  • Publication number: 20180059550
    Abstract: In accordance with an embodiment of the disclosure, a tip array can include an elastomeric tip substrate layer comprising a first surface and an oppositely disposed second surface, the tip substrate layer being formed from an elastomeric material; a plurality of tips fixed to the first surface, the tips each comprising a tip end disposed opposite the first surface, the tips having a radius of curvature of less than about 1 micron; and an array of heaters disposed on the second surface of the tip substrate layer and configured such that when the tip substrate layer is heated by a heater, a tip disposed in a location of a heated portion of tip substrate layer is lowered relative to a tip disposed in a location of an unheated portion of the tip substrate layer.
    Type: Application
    Filed: September 1, 2017
    Publication date: March 1, 2018
    Inventors: Chad A. Mirkin, Xing Liao, Keith A. Brown, Guoliang Liu, Abrin L. Schmucke, Shu He, Wooyoung Shim, Daniel J. Eichelsdoerfer, Boris Rasin
  • Patent number: 9890427
    Abstract: Methods describing the use of nanoparticles modified with binding moieties are provided.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: February 13, 2018
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, Dwight S. Seferos, David A. Giljohann
  • Patent number: 9889209
    Abstract: The present disclosure is directed to nanoconjugates that cross the blood-brain barrier and methods of their therapeutic use.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: February 13, 2018
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, Caroline H. Ko, Alexander Stegh, David A. Giljohann, Janina Luciano, Samuel A. Jensen