Abstract: Methods and apparatus providing a patient digital twin are disclosed. An example apparatus includes a processor and a memory. The example processor is to configure the memory according to a patient digital twin of a first patient. The example patient digital twin is to include a data structure created from a combination of patient medical record data, image data, genetic information, and historical information, the combination extracted from one or more information systems and arranged in the data structure to form a digital representation of the first patient. The example patient digital twin is to be arranged for query and simulation via the processor. The example patient digital twin is to be combinable with one or more rules to generate, using the processor, a recommendation for a patient health outcome based on modeling the patient digital twin as instructed by the one or more rules.