Patents by Inventor Chad E. Stephens

Chad E. Stephens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,5-DIARYL SELENOPHENE COMPOUNDS, AZA 2,5-DIARYL THIOPHENE COMPOUNDS, AND THEIR PRODRUGS AS ANTIPROTOZOAL AGENTS
    Publication number: 20100331368
    Abstract: Novel dicationic 2,5-diaryl selenophene compounds are described. Also described are novel aza analogues of dicationic 2,5-diaryl thiophenes. The presently disclosed dicationic compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, and/or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic compounds display good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.
    Type: Application
    Filed: October 17, 2008
    Publication date: December 30, 2010
    Inventors: Richard R. Tidwell, David W. Boykin, Chad E. Stephens, Mohamed A. Ismail, Arvind Kumar, W. David Wilson, Reto Brun, Karl Werbovetz
  • Fused ring dicationic anti-protozoan agents and their prodrugs
    Patent number: 7825279
    Abstract: Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r.) and Plasmodium falciparum. Prodrugs of these compounds can be used as an oral treatment for malaria and human African trypanosomiasis.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: November 2, 2010
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc.
    Inventors: David W. Boykin, Richard R. Tidwell, W. David Wilson, Reto Brun, Reem K. Arafa, Chad E. Stephens
  • Reversed amidines and methods of using for treating, preventing, or inhibiting leishmaniasis
    Patent number: 6706754
    Abstract: Methods for treating, preventing or inhibiting leishmaniasis in a subject comprising administering to the subject a therapeutically effective amount of at least one compound having the structural formula wherein Y is a heteroatom; R1 and R2 are independently H or an alkyl, cycloalkyl, heterocycloalkyl, aryl, amino or heteroaryl group; and X1, X2, and X3 are independently H or an alkyl, alkoxy, halo, amino, alkylamino, dialkylamino, acylamino, alkylthio, sulfonyl, cyano, carboxy, alkoxycarbonyl, or carbamoyl group are disclosed.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: March 16, 2004
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Karl A. Werbovetz, James J. Brendle, David W. Boykin, Chad E. Stephens
  • Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
    Publication number: 20030199521
    Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.
    Type: Application
    Filed: January 11, 2002
    Publication date: October 23, 2003
    Inventors: Christine C. Dykstra, Maurice Daniel Givens, David A. Stringfellow, Kenny Brock, David Boykin, Arvind Kumar, W. David Wilson, Richard R. Tidwell, Chad E. Stephens
  • Reversed amidines and methods of using for treating, preventing, or inhibiting leishmaniasis
    Publication number: 20020156098
    Abstract: Methods for treating, preventing or inhibiting leishmaniasis in a subject comprising administering to the subject a therapeutically effective amount of at least one compound having the structural formula 1
    Type: Application
    Filed: November 5, 2001
    Publication date: October 24, 2002
    Inventors: Karl A. Werbovetz, James J. Brendle, David W. Boykin, Chad E. Stephens