Abstract: A speculum of an otoscope may include a housing and a seal. The seal may include a surface sized and shaped to interface with an external auditory meatus. In some examples, the seal comprises one or more compressible members deformable to interface with the external auditory meatus. The seal may be configured to retain a volume of fluid within a lumen of the speculum in response to one or more of a negative pressure change or a positive pressure change.

Abstract: A device for measuring reflected ultrasound and optical signals may include: an optical source; an optical assembly comprising at least one lens, configured to focus reflected optical illumination from a target onto a detector; and an ultrasound transducer aligned to transmit and receive ultrasound radiation co-axially with the reflected optical illumination and wherein the ultrasound transducer at least partially obstructs a path of the reflected optical illumination. An obstruction may be distant from a focal spot of the optical assembly. The device for measuring reflected ultrasound and optical signals may be particularly useful for characterizing fluid behind an ear drum to diagnose otitis media.

Abstract: A device for measuring reflected ultrasound and optical signals may include: an optical source; an optical assembly comprising at least one lens, configured to focus reflected optical illumination from a target onto a detector; and an ultrasound transducer aligned to transmit and receive ultrasound radiation co-axially with the reflected optical illumination and wherein the ultrasound transducer at least partially obstructs a path of the reflected optical illumination. An obstruction may be distant from a focal spot of the optical assembly. The device for measuring reflected ultrasound and optical signals may be particularly useful for characterizing fluid behind an ear drum to diagnose otitis media.

Abstract: Cutaneous treatment apparatuses are provided that enhance percutaneous absorption of a treatment formulation. Related methods are also provided. In general, examples of the cutaneous treatment systems and/or apparatuses described herein are capable of attaching to a cutaneous surface and applying a treatment formulation to a localized cutaneous region. Embodiments of a cutaneous treatment apparatus generally include a heater and a treatment delivery component, including a treatment portion. The treatment portion includes a treatment formulation, including a therapeutic compound, and a treatment surface configured to contact the cutaneous region. The heater component is removably couplable with the treatment delivery component and is configured to transfer heat to the treatment portion. Upon heating, the therapeutic compound is configured to release from the treatment portion through the treatment surface towards the cutaneous region.