Patents by Inventor Chad Pecot

Chad Pecot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INVERTED CHIMERIC siRNA MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20240309384
    Abstract: The invention relates to inverted chimera siRNA molecules and their use for the inhibition of expression of one or more target genes. The invention further relates to the inhibition of expression of c-Myc, or the dual inhibition of c-Myc and KRAS, using RNA interference, chemically-modified oligonucleotides, and/or chimeric siRNA multivalent combinations.
    Type: Application
    Filed: June 21, 2022
    Publication date: September 19, 2024
    Inventors: Chad Pecot, Yogitha Chareddy
  • NUCLEIC ACID LIGAND CONJUGATES AND USE THEREOF FOR DELIVERY TO CELLS
    Publication number: 20230285579
    Abstract: The present invention relates to conjugated products comprising a ligand linked to a nucleic acid. The invention further relates to methods for delivering a nucleic acid to a cell and treating a disease using the conjugated products. The invention further relates to methods of increasing uptake of a nucleic acid by a cell comprising conjugating the nucleic acid to a ligand to form the conjugated product of the invention.
    Type: Application
    Filed: May 12, 2021
    Publication date: September 14, 2023
    Inventors: Chad Pecot, Salma H. Azam, Albert Bowers, Matthew Cyril Fleming
  • METHODS AND COMPOSITIONS USING RNA INTERFERENCE AND ANTISENSE OLIGONUCLEOTIDES FOR INHIBITION OF KRAS
    Publication number: 20220073923
    Abstract: The invention relates to the inhibition of expression of mutant KRAS sequences using RNA interference, antisense oligonucleotides, and chemically-modified oligonucleotides.
    Type: Application
    Filed: November 22, 2021
    Publication date: March 10, 2022
    Inventors: Chad Pecot, Salma H. Azam
  • Methods and compositions using RNA interference and antisense oligonucleotides for inhibition of KRAS
    Patent number: 11180759
    Abstract: The invention relates to the inhibition of expression of mutant KRAS sequences using RNA interference, antisense oligonucleotides, and chemically-modified oligonucleotides.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: November 23, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Chad Pecot, Salma H. Azam
  • METHODS AND COMPOSITIONS USING RNA INTERFERENCE AND ANTISENSE OLIGONUCLEOTIDES FOR INHIBITION OF KRAS
    Publication number: 20200248185
    Abstract: The invention relates to the inhibition of expression of mutant KRAS sequences using RNA interference, antisense oligonucleotides, and chemically-modified oligonucleotides.
    Type: Application
    Filed: April 7, 2020
    Publication date: August 6, 2020
    Inventors: Chad Pecot, Salma H. Azam
  • Methods and compositions using RNA interference for inhibition of KRAS
    Patent number: 10619159
    Abstract: The invention relates to the inhibition of expression of mutant KRAS sequences using RNA interference.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: April 14, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Chad Pecot, Adrienne Cox, Channing Der
  • METHODS AND COMPOSITIONS USING RNA INTERFERENCE FOR INHIBITION OF KRAS
    Publication number: 20190055562
    Abstract: The invention relates to the inhibition of expression of mutant KRAS sequences using RNA interference.
    Type: Application
    Filed: January 19, 2017
    Publication date: February 21, 2019
    Inventors: Chad Pecot, Adrienne Cox, Channing Der