Abstract: Methods and systems to analyze and predict patient-specific physiological behavior of a human organ or anatomical entity such as the heart complex and the heart subcomponents from 3-dimensional volumetric ultrasound (3D) or time-sequential volumetric (4D) ultrasound image data, to assist physicians in performing diagnostics and cardiac preoperative planning. Also disclosed herein are methods and systems to segment patient-specific anatomical features from 3D/4D ultrasound. Also disclosed herein are methods and systems to compute patient-specific tissue motion and blood flow from 3D/4D ultrasound and contrast-enhanced 3D/4D ultrasound image data. Also disclosed herein are methods and systems to simulate the patient-specific mechanical behavior of the organ and anatomical entity using both 3D/4D ultrasound and mechanical models. Also disclosed herein are methods and systems to estimate tissue stress and strain and physiological parameters of the tissues from 3D/4D ultrasound.