Abstract: Syringe having a plunger, a barrel and a restrictor mechanism between the shaft of the plunger and the barrel and including a first part engaged with the barrel for limiting movement of the first part with respect to the barrel in a first direction, and a second part. The restrictor mechanism and/or plunger shaft carries a formation for limiting movement of the restrictor mechanism with respect to the plunger in the first direction. The restrictor mechanism as a further member which restricts movement of the restrictor mechanism with respect to the barrel or plunger shaft in a second direction. A latch member prevents he further member from restricting movement of the restrictor mechanism with respect to the barrel or plunger shaft in the second direction until a predetermined point in an operation cycle of the syringe.

Abstract: An auto-disable syringe (50,150) is disclosed which prevents re-use of the syringe whatever dose is delivered on the first use. A restrictor bobbin comprises an element (1,100) which spans the barrel of the syringe and which, after initial distal movement of the plunger (52, 152) rotates and wedges in the barrel when the plunger is moved proximally. The wedged restrictor bobbin (1, 100) prevents further substantial proximal movement of the plunger (52, 152) whilst allowing further distal movement. A small degree of repeated proximal and distal movement is permitted to allow for an aspiration step.

Abstract: A system and method for a patch-like, self-contained substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir subassembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. Simple removal of an interlock allows a disk, or Belleville spring assembly to apply an essentially even and constant pressure to the contents of the fluid reservoir assembly, and allows the device to then be attached to a skin surface via an adhesive contact surface. A push button activation assembly is provided which can then be used to release and seat one or more spring-loaded patient needles into the skin surface, and establish a fluid communication path between the patient needles and the pressurized fluid reservoir contents thereby delivering an infusion into the skin.

Abstract: A retainer for filling and sealing containers having one or more flexible sides which has features for filling semi-flexible containers is disclosed. Non-standard containers for holding fluid are releasably supported during the filling and sealing process. Both the interior and exterior of the filled container are subjected to an environment of reduced pressure to minimize the headspace and sealed.

Abstract: An auto-disable syringe (50,150) is disclosed which prevents re-use of the syringe whatever dose is delivered on the first use. A restrictor bobbin comprises an element (1,100) which spans the barrel of the syringe and which, after initial distal movement of the plunger (52, 152) rotates and wedges in the barrel when the plunger is moved proximally. The wedged restrictor bobbin (1, 100) prevents further substantial proximal movement of the plunger (52, 152) whilst allowing further distal movement. A small degree of repeated proximal and distal movement is permitted to allow for an aspiration step.

Abstract: An auto-disable syringe is disclosed which prevents re-use of the syringe whetver dose is delivered on the first use. A restrictor bobbin comprises two elements: a plunger lock 1 and a barrel lock 20 which are relatively freely movable for a limited distance. The barrel lock includes a barb 27 which engages with the barrel interior wall to prevent proximal movement of the barrel lock, whilst the plunger lock includes a barb 6 which engages with the plunger to prevent distal movement of the plunger withy respect to the barrel lock. The plunger lock includes a further barb 9 which is engageable with the plunger to prevent proximal movement of the plunger. A lock release 40 inlcudes a latch tine 53 which, in the syringe as shipped, prevents engagement of the barb 9 with the plunger. After withdrawal of fluid, e.g. a liquid medicament, initial distal movement of the plunger causes the latch 53 to disengage with the barb 9, thereby preventing any further proximal movement of the plunger.

Abstract: Methods for filling and sealing containers having one or more flexible sides. Non-standard containers for holding fluid are releasably supported during the filling and sealing process. Both the interior and exterior of the filled container are subjected to an environment of reduced pressure to minimize the headspace and sealed.

Abstract: An auto-disable syringe is disclosed which prevents re-use of the syringe whetver dose is delivered on the first use. A restrictor bobbin comprises two elements: a plunger lock 1 and a barrel lock 20 which are relatively freely movable for a limited distance. The barrel lock includes a barb 27 which engages with the barrel interior wall to prevent proximal movement of the barrel lock, whilst the plunger lock includes a barb 6 which engages with the plunger to prevent distal movement of the plunger withy respect to the barrel lock. The plunger lock includes a further barb 9 which is engageable with the plunger to prevent proximal movement of the plunger. A lock release 40 inlcudes a latch tine 53 which, in the syringe as shipped, prevents engagement of the barb 9 with the plunger. After withdrawal of fluid, e.g. a liquid medicament, initial distal movement of the plunger causes the latch 53 to disengage with the barb 9, thereby preventing any further proximal movement of the plunger.

Abstract: A needle assembly includes a needle component (10) and a blunting component (26), the needle component (10) containing a needle cannula (12) mounted in a housing (16) which defines a fluid chamber such as a fluid chamber (20). The blunting component (26) contains a non-perforated, open-ended blunting probe (28) mounted in a shuttle (30). The needle cannula (12) and the blunting probe (28) are disposed telescopically one within the other without obstructing flow through the needle passageway, and are movable between a sharpened configuration and a blunted configuration. The blunting member (26) is configured to permit the open end of the blunting probe (28) to provide flow access to the fluid chamber (20) in the housing (16).