Abstract: A laminated lidstock includes a substrate film, a support web; a pressure sensitive adhesive disposed between the substrate and support webs, and covering the substrate film and support web; a product die cut disposed in the substrate film; and an array of opening die cuts disposed in the substrate film; wherein at least one of substrate film and the support web comprises an oxygen barrier, and wherein at least one of the substrate film and the support web carries a registration device. A method of making the lidstock, and a package, are also disclosed.

Abstract: A laminated lidstock includes a substrate film, a support web; a pressure sensitive adhesive disposed between the substrate and support webs, and covering the substrate film and support web except for a clear area disposed near one end of the laminated lidstock; a first die cut disposed in the substrate film; a second die cut disposed in the support web; a pull tab; and a tamper evidence device including an end portion of the support web, defined by a first end, a first side edge, and a second side edge of the package made from the laminated lidstock, and the second die cut, capable of indicating tampering of the package upon removal of the tamper evidence device from the support web; wherein at least one of the substrate film and the support web carries a registration device.

Abstract: A laminated lidstock includes a substrate film, a support web; a pressure sensitive adhesive disposed between the substrate and support webs, and covering the substrate film and support web except for a clear area at one end of the lidstock; a product die cut disposed in the substrate film; and a pull tab disposed at a first end of the laminated lidstock, wherein at least one of the substrate film and the support web carries a registration device. A method of making the lidstock, and a package, are also disclosed.

Abstract: A laminated lidstock includes a substrate film, a support web; a pressure sensitive adhesive disposed between the substrate and support webs, and covering the substrate film and support web; a product die cut disposed in the substrate film; and an array of opening die cuts disposed in the substrate film; wherein at least one of substrate film and the support web comprises an oxygen barrier, and wherein at least one of the substrate film and the support web carries a registration device. A method of making the lidstock, and a package, are also disclosed.

Abstract: A laminated lidstock includes a substrate film, a support web; a pressure sensitive adhesive disposed between the substrate and support webs, and covering the substrate film and support web except for a clear area disposed near one end of the laminated lidstock; a first die cut disposed in the substrate film; a second die cut disposed in the support web; a pull tab; and a tamper evidence device including an end portion of the support web, defined by a first end, a first side edge, and a second side edge of the package made from the laminated lidstock, and the second die cut, capable of indicating tampering of the package upon removal of the tamper evidence device from the support web; wherein at least one of the substrate film and the support web carries a registration device.

Abstract: Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.

Abstract: The present invention relates to novel 2,5-bis{[alkyl(or aryl)imino]aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.

Abstract: Dicationic compounds for the treatment of T. vaginalis infections are described. The presently described compounds exhibit in vitro activity against metronidazole-sensitive and -resistant T. vaginalis isolates. Furthermore, the presently described compounds demonstrate IC50 concentrations that were not elevated in the metronidazole resistant isolate, suggesting that their activity is not affected by parasite mechanisms that confer resistance to 5-nitroimidizoles.

Abstract: Novel amidine and diamidine compounds are useful in the treatment of microbial infections, including mycobacterial, fungal and protozoal infections. Pharmaceutical formulations comprising these compounds can be used in methods of treating microbial infections.

Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

Abstract: Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.

Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

Abstract: Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r.) and Plasmodium falciparum. Prodrugs of these compounds can be used as an oral treatment for malaria and human African trypanosomiasis.