Abstract: The present disclosure generally relates to using high frequency ultrasound to assess blood volume changes in a subject. A baseline blood volume value can be determined based on a weight of a subject or based on an initial/previous assessment test value. An image taken with the high frequency ultrasound can be retrieved. A test blood volume value can be measured in a field of view of the image. For example, the test blood volume can be determined based on a destruction/replenishment of a contrast agent during imaging by the high frequency ultrasound. A change in blood volume in the subject can be estimated by comparing the test blood volume value to the baseline blood volume value. The estimate of the change in blood volume can be used to assess a condition of the subject.

Abstract: One aspect of the present disclosure relates to a device for aspirating a biological tissue from a subject. The device can comprise a flexible, hollow shaft and an ultrasound assembly. The shaft can have a central portion that extends between a proximal end and a distal end thereof. The shaft can include a first lumen that extends between the proximal and distal ends. The ultrasound assembly can be connected to the distal end of the shaft. The ultrasound assembly can include a casing, at least one ultrasound transducer disposed within the casing, and a second lumen that extends through the ultrasound assembly and is in fluid communication with the first lumen. The at least one ultrasound transducer can be configured to generate acoustical waves having an intensity and frequency sufficient to disrupt, but not substantially damage, the biological tissue so that the biological tissue can be aspirated through the device.

Abstract: The present disclosure generally relates to using high frequency ultrasound to assess blood volume changes in a subject. A baseline blood volume value can be determined based on a weight of a subject or based on an initial/previous assessment test value. An image taken with the high frequency ultrasound can be retrieved. A test blood volume value can be measured in a field of view of the image. For example, the test blood volume can be determined based on a destruction/replenishment of a contrast agent during imaging by the high frequency ultrasound. A change in blood volume in the subject can be estimated by comparing the test blood volume value to the baseline blood volume value. The estimate of the change in blood volume can be used to assess a condition of the subject.

Abstract: One aspect of the present disclosure relates to a device for aspirating a biological tissue from a subject. The device can comprise a flexible, hollow shaft and an ultrasound assembly. The shaft can have a central portion that extends between a proximal end and a distal end thereof. The shaft can include a first lumen that extends between the proximal and distal ends. The ultrasound assembly can be connected to the distal end of the shaft. The ultrasound assembly can include a casing, at least one ultrasound transducer disposed within the casing, and a second lumen that extends through the ultrasound assembly and is in fluid communication with the first lumen. The at least one ultrasound transducer can be configured to generate acoustical waves having an intensity and frequency sufficient to disrupt, but not substantially damage, the biological tissue so that the biological tissue can be aspirated through the device.