Patents by Inventor Chafen Lu

Chafen Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250206802
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Application
    Filed: January 30, 2025
    Publication date: June 26, 2025
    Applicant: The Children's Medical Center Corporation
    Inventors: Timothy Alan Springer, Xianchi Dong, Chafen Lu
  • Publication number: 20240117006
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Application
    Filed: September 29, 2023
    Publication date: April 11, 2024
    Applicant: The Children's Medical Center Corporation
    Inventors: Timothy Alan Springer, Xianchi Dong, Chafen Lu
  • Publication number: 20220064261
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Application
    Filed: July 23, 2021
    Publication date: March 3, 2022
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Timothy Alan SPRINGER, Xianchi Dong, Chafen Lu
  • Patent number: 11136383
    Abstract: Disclosed are compositions and methods for modulating the activity of TGF-?. More particularly, compositions and methods for modulating the release of active TGF-? from an LRRC33-TGF-? prodomain-TGF-? ternary complex are provided, as are and methods of treatment based upon such modulation.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: October 5, 2021
    Assignee: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Timothy Alan Springer, Chafen Lu, Yan Qin, Aiping Jiang
  • Patent number: 11104713
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: August 31, 2021
    Assignee: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Timothy Alan Springer, Xianchi Dong, Chafen Lu
  • Publication number: 20200031900
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Application
    Filed: March 8, 2019
    Publication date: January 30, 2020
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Timothy Alan SPRINGER, Xianchi DONG, Chafen LU
  • Publication number: 20190270798
    Abstract: Disclosed are compositions and methods for modulating the activity of TGF-?. More particularly, compositions and methods for modulating the release of active TGF-? from an LRRC33-TGF-? prodomain-TGF? ternary complex are provided, as are and methods of treatment based upon such modulation.
    Type: Application
    Filed: October 25, 2017
    Publication date: September 5, 2019
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Timothy Alan SPRINGER, Chafen LU, Yan QIN, Aiping JIANG
  • Patent number: 10273283
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: April 30, 2019
    Assignee: The Children's Medical Center Corporation
    Inventors: Timothy Alan Springer, Xianchi Dong, Chafen Lu
  • Publication number: 20170183390
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Application
    Filed: February 3, 2017
    Publication date: June 29, 2017
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Timothy Alan SPRINGER, Xianchi DONG, Chafen LU
  • Patent number: 9580482
    Abstract: This invention relates to compositions and methods for eliciting an immune response against a parasite of the genus Plasmodium in a mammal.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: February 28, 2017
    Assignee: Children's Medical Center Corporation
    Inventors: Timothy A. Springer, Chafen Lu, Gaojie Song, Adem Koksal
  • Publication number: 20150147349
    Abstract: This invention relates to compositions and methods for eliciting an immune response against a parasite of the genus Plasmodium in a mammal.
    Type: Application
    Filed: February 15, 2013
    Publication date: May 28, 2015
    Inventors: Timothy A. Springer, Chafen Lu, Gaojie Song, Adem Koksal
  • Patent number: 8241627
    Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where crysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: August 14, 2012
    Assignee: The Center for Blood Research, Inc.
    Inventors: Timothy A. Springer, Motomu Shimaoka, Chafen Lu
  • Publication number: 20110305691
    Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where crysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.
    Type: Application
    Filed: June 22, 2011
    Publication date: December 15, 2011
    Applicant: THE CENTER FOR BLOOD RESEARCH, INC.
    Inventors: Timothy A. Springer, Motomu Shimaoka, Chafen Lu
  • Patent number: 7968284
    Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: June 28, 2011
    Assignee: The Center for Blood Research, Inc.
    Inventors: Timothy A. Springer, Motomu Shimaoka, Chafen Lu
  • Publication number: 20110111528
    Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.
    Type: Application
    Filed: December 10, 2010
    Publication date: May 12, 2011
    Applicant: THE CENTER FOR BLOOD RESEARCH, INC.
    Inventors: Timothy A. Springer, Motomu Shimaoka, Chafen Lu
  • Patent number: 7879577
    Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: February 1, 2011
    Assignee: The Center for Blood Research, Inc.
    Inventors: Timothy A. Springer, Motomu Shimaoka, Chafen Lu
  • Publication number: 20100113742
    Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.
    Type: Application
    Filed: November 20, 2009
    Publication date: May 6, 2010
    Applicant: The Center for Blood Research, Inc.
    Inventors: Timothy A. Springer, Motomu Shimaoka, Chafen Lu
  • Patent number: 7674604
    Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. Modified integrin I-domain polypeptides stabilized in a desired conformation are also provided, as well as screening assays and therapeutic methods utilizing the modified integrin I-domain polypeptides.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: March 9, 2010
    Assignee: The Center for Blood Research, Inc.
    Inventors: Timothy A. Springer, Motomu Shimaoka, Chafen Lu
  • Patent number: 7241869
    Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: July 10, 2007
    Assignee: Center for Blood Research, Inc.
    Inventors: Timothy A. Springer, Motomu Shimaoka, Chafen Lu
  • Patent number: 7160541
    Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. Modified integrin I-domain polypeptides that are stabilized in a desired conformation are also provided. Finally, screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention are also provided.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: January 9, 2007
    Assignee: The Center for Blood Research, Inc.
    Inventors: Timothy A. Springer, Motomu Shimaoka, Chafen Lu