Patents by Inventor Chaim Eidelman

Chaim Eidelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid state forms of linaclotide
    Patent number: 10889620
    Abstract: Solid state forms of Linaclotide, processes for their preparation, compositions comprising them and medical uses thereof are provided. The solid state forms of Linaclotide are useful in the preparation of other solid state forms of Linaclotide, particularly the amorphous form.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: January 12, 2021
    Assignee: NOVETIDE LTD.
    Inventors: Chaim Eidelman, Hagi Alon, Dov Vayer, Sharon Penias-Navon, Jonathan Enav
  • SOLID STATE FORMS OF LINACLOTIDE
    Publication number: 20190194256
    Abstract: Solid state forms of Linaclotide, processes for their preparation, compositions comprising them and medical uses thereof are provided. The solid state forms of Linaclotide are useful in the preparation of other solid state forms of Linaclotide, particularly the amorphous form.
    Type: Application
    Filed: July 1, 2016
    Publication date: June 27, 2019
    Inventors: Chaim EIDELMAN, Hagi ALON, Dov VAYER, Sharon PENIAS-NAVON, Jonathan ENAV
  • PROCESS FOR PRODUCTION OF BIVALIRUDIN
    Publication number: 20160324943
    Abstract: The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp9-Bivalirudin] and each is impurity less than 1.0%, and preferably having a purity of at least about 99.0% by HPLC, wherein the total impurities amount to less than 1.0%, comprising not more than 0.5% [Asp9-Bivalirudin] and each impurity is less than 0.5%.
    Type: Application
    Filed: August 26, 2015
    Publication date: November 10, 2016
    Applicant: TEVA PHARMACEUTICALS USA, INC.
    Inventors: Avi TOVI, Chaim EIDELMAN, Shimon SHUSHAN, Alon HAGI, Alexander IVCHENKO, Gabriel-Marcus BUTILCA, Leah BAR-OZ, Tehila GADI, Gil ZAOVI
  • PRODUCTION OF PEPTIDES CONTAINING POLY-GLY SEQUENCES USING FMOC CHEMISTRY
    Publication number: 20110160431
    Abstract: A peptide containing a poly-Gly sequence, such as bivalirudin, can be prepared in a purified form in which low amounts of GIy deletion or GIy addition byproducts are present. A protected poly-Gly-containing peptide is attached to a resin using Fmoc-Gly-GIy-OH units for assembly of the poly-Gly segment. The protected peptide is then cleaved from the resin with an acidic composition to produce an unprotected or semi-protected crude peptide, which can then be isolated from acidic composition.
    Type: Application
    Filed: March 29, 2010
    Publication date: June 30, 2011
    Applicant: NOVETIDE, LTD.
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Hagi Alon, Alexander Ivchenko, Leah Bar-0z
  • PROCESS FOR PRODUCTION OF BIVALIRUDIN
    Publication number: 20100273982
    Abstract: The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp9-Bivalirudin] and each is impurity less than 1.0%, and preferably having a purity of at least about 99.0% by HPLC, wherein the total impurities amount to less than 1.0%, comprising not more than 0.5% [Asp9-Bivalirudin] and each impurity is less than 0.5%.
    Type: Application
    Filed: August 5, 2009
    Publication date: October 28, 2010
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Alon Hagi, Alexander Ivchenko, Gabriel-Marcus Butilca, Leah Bar-Oz, Tehila Gadi, Gil Zaovi
  • Processes for preparing high purity aza cyclohexapeptides
    Publication number: 20100256074
    Abstract: Provided are processes for the preparation and purification of high purity aza cyclohexapeptides.
    Type: Application
    Filed: June 25, 2009
    Publication date: October 7, 2010
    Inventors: Chaim Eidelman, Avi Tovi, Hagai Alon, Vitali Pirogov, Adelina Gelfond, Csilla Nemethne Racz, Ferenc Korodi, Piroska Kovacs, Amir Gold, Alexander Rudinski
  • PROCESS FOR PRODUCTION OF CYCLIC PEPTIDES
    Publication number: 20100240865
    Abstract: The invention relates to methods for the preparation of polypeptides. The polypeptides are prepared in high purity of at least about 98.5%, and preferably at least about 99% by HPLC.
    Type: Application
    Filed: February 4, 2010
    Publication date: September 23, 2010
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Shai Elster, Hagi Alon
  • PROCESS FOR PRODUCTION OF CYCLIC PEPTIDES
    Publication number: 20100137559
    Abstract: The invention relates to methods for the preparation of polypeptides. The polypeptides are prepared in high purity of at least about 98.5%, and preferably at least about 99% by HPLC.
    Type: Application
    Filed: February 4, 2010
    Publication date: June 3, 2010
    Inventors: Avi TOVI, Chaim Eidelman, Shimon Shushan, Shai Elster, Hagi Alon
  • PROCESS FOR PRODUCTION OF BIVALIRUDIN
    Publication number: 20100029916
    Abstract: The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp9-Bivalirudin] and each is impurity less than 1.0%, and preferably having a purity of at least about 99.0% by HPLC, wherein the total impurities amount to less than 1.0%, comprising not more than 0.5% [Asp9-Bivalirudin] and each impurity is less than 0.5%.
    Type: Application
    Filed: August 5, 2009
    Publication date: February 4, 2010
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Alon Hagi, Alexander Ivchenko, Gabriel-Marcus Butilca, Leah Bar-Oz, Tehila Gadi, Gil Zaovi
  • Caspofungin free of caspofungin impurity A
    Publication number: 20090324635
    Abstract: Provided is caspofungin free of caspofungin impurity A, methods for preparation thereof and isolation of caspofungin impurity A.
    Type: Application
    Filed: June 25, 2009
    Publication date: December 31, 2009
    Inventors: Ferenc Korodi, Piroska Kovacs, Chaim Eidelman, Avi Tovi, Hagi Alon
  • High purity peptides
    Publication number: 20080287650
    Abstract: The invention relates to methods for the preparation of highly purified peptides. The peptides are prepared in high optical purity of at least about 98.5%, and preferably at least about 99%. Specifically, Nesiritide (SEQ. ID NO. 1) having a purity of at least 99% as measured by HPLC and containing about 0.05% to about 0.5% [D-His]-Nesiritide (SEQ. ID NO. 1) as measured by chiral GC/MS.
    Type: Application
    Filed: March 3, 2008
    Publication date: November 20, 2008
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Shai Elster, Alon Hagi, Alexander Ivchenko, Gabriel-Marcus Butilca, Gil Zaoui, Eleonora Alterman, Leah Bar-Oz
  • Process for production of Bivalirudin
    Publication number: 20070093423
    Abstract: The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp9-Bivalirudin] and each is impurity less than 1.0%, and preferably having a purity of at least about 99.0% by HPLC, wherein the total impurities amount to less than 1.0%, comprising not more than 0.5% [Asp9-Bivalirudin] and each impurity is less than 0.5%.
    Type: Application
    Filed: September 14, 2006
    Publication date: April 26, 2007
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Alon Hagi, Alexander Ivchenko, Gabriel-Marcus Butilca, Leah Bar-Oz, Tehila Gadi, Gil Zaovi
  • Methods for the production of peptide derivatives
    Publication number: 20060276626
    Abstract: The invention relates to methods for the preparation of peptides which are a C-terminal amide derivatives by a combination of solid-phase synthesis and post assembly solution phase synthesis. The peptides which are a C-terminal amide derivatives are further converted to peptide acetates. The invention also relates to pure peptide acetates and to protected peptide precursors.
    Type: Application
    Filed: May 2, 2006
    Publication date: December 7, 2006
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Shai Elster, Hagi Alon, Alexander Ivchenko, Gabriel-Marcus Butilca, Gil Zaovi, Eleonora Alterman, Leah Bar-Oz, Tehila Gadi
  • Counterion exchange process for peptides
    Publication number: 20060148699
    Abstract: The invention encompasses a process for purifying a peptide comprising loading a peptide onto a RP-HPLC column; washing the column with an aqueous solution of a pharmaceutically acceptable counterion salt; and eluting the peptide from the column with a solvent mixture of a organic solvent and an acid of the pharmaceutically acceptable counterion, wherein the aqueous solution has a pH of at least about 6.
    Type: Application
    Filed: October 4, 2005
    Publication date: July 6, 2006
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Shai Elster, Hagi Alon, Alexander Ivchenko, Gabriel-Marcus Butilca, Gil Zaovi
  • Process for production of cyclic peptides
    Publication number: 20040249121
    Abstract: The invention relates to methods for the preparation of polypeptides. The polypeptides are prepared in high purity of at least about 98.5%, and preferably at least about 99% by HPLC.
    Type: Application
    Filed: April 5, 2004
    Publication date: December 9, 2004
    Inventors: Avi Tovi, Chaim Eidelman, Shimon Shushan, Shai Elster, Hagi Alon
  • Process for the manufacture of substituted maleimides
    Patent number: 5306828
    Abstract: In a process for the preparation of substituted maleimides the corresponding amines are reacted with maleic anhydride and the thermal imidization of the resulting substituted amic-acids is effected in a mixed apolar/polar aprotic solvent medium in the presence of an acid catalyst, a substantial portion of the apolar solvent is subsequently selectively removed from the reaction mixture and most of the final product is precipitated.
    Type: Grant
    Filed: February 13, 1992
    Date of Patent: April 26, 1994
    Assignee: Bromine Compounds Ltd.
    Inventors: Michel Adda, Chaim Eidelman, Leonard Shorr