Patents by Inventor Chaitan Khosla

Chaitan Khosla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic Method for Celiac Sprue
    Publication number: 20120083004
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.
    Type: Application
    Filed: November 4, 2011
    Publication date: April 5, 2012
    Inventors: Chaitan Khosla, Lu Shan
  • Scaleable manufacturing process for cysteine endoprotease B, isoform 2
    Patent number: 8148105
    Abstract: Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and purification processes, which processes may be combined with lyophilization to yield a stable product.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: April 3, 2012
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Alvine Pharmaceuticals, Inc.
    Inventors: Harmit Vora, James McIntire, Pawan Kumar, Chaitan Khosla
  • Enzyme treatment of foodstuffs for celiac sprue
    Patent number: 8143210
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: March 27, 2012
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Alvine Pharmaceuticals, Inc.
    Inventors: Lu Shan, Chaitan Khosla
  • Diagnostic method for celiac sprue
    Patent number: 8071316
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: December 6, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Lu Shan
  • Enzyme Treatment of Foodstuffs for Celiac Sprue
    Publication number: 20110293724
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: March 21, 2011
    Publication date: December 1, 2011
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Drug Therapy for Celiac Sprue
    Publication number: 20110286995
    Abstract: Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Application
    Filed: June 13, 2011
    Publication date: November 24, 2011
    Inventors: CHAITAN KHOSLA, KIHANG CHOI
  • Ketolide anti-infective compounds
    Patent number: 8063021
    Abstract: Compounds according to formula I wherein m is 0 or 1; X is and R1, R2, R3 R4, and R5 are as defined herein, are useful as anti-infective agents.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: November 22, 2011
    Assignee: Kosan Biosciences Incorporated
    Inventors: Yong Li, Yandong Li, Yan Zhu, Chaitan Khosla, David C. Myles
  • Enzyme treatment of foodstuffs for celiac sprue
    Patent number: 7943312
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: May 17, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Enzyme treatment of foodstuffs for Celiac Sprue
    Patent number: 7928056
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: April 19, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Methods for diagnosing celiac sprue and reagents useful therein
    Patent number: 7923532
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: April 12, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Enzyme treatment of foodstuffs for celiac sprue
    Patent number: 7910541
    Abstract: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: March 22, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Felix Hausch, Gary Gray, Lu Shan, Chaitan Khosla
  • Biomarker to Measure Drug Efficacy in Enteropathic Disease
    Publication number: 20110027897
    Abstract: The response of a patient with an enteropathic disease to therapy, particularly a candidate therapy in a clinical trial setting, is assessed by detecting the ability of the patient to metabolize an orally administered CYP3A substrate. The CYP3A metabolism may be monitored in a variety of ways. Conveniently, the appearance of a metabolite of the CYP3A substrate is detected in a patient sample over a period of time following oral administration, e.g. in urine, plasma, breath, saliva, etc. The CYP3A substrate is optionally labeled, e.g. with an isotopic, fluorescent, etc. label.
    Type: Application
    Filed: August 28, 2008
    Publication date: February 3, 2011
    Inventors: Chaitan Khosla, Michael Bethune
  • Combination Enzyme Therapy for Gastric Digestion of Dietary Gluten in Celiac Sprue Patients
    Publication number: 20100322912
    Abstract: Combination enzyme products and methods of use thereof are provided. Aspergillopepsin I is combined with a protease enzyme that provides for an additive or synergistic effect in the digestion of toxic gluten oligopeptides. The enzyme products are useful in the treatment of Celiac Sprue patients, particularly for patients who continue to exhibit signs or symptoms of active disease despite following a gluten-free diet.
    Type: Application
    Filed: December 8, 2008
    Publication date: December 23, 2010
    Inventors: Chaitan Khosla, Jennifer Ehren
  • Diagnostic Method for Celiac Sprue
    Publication number: 20100317025
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.
    Type: Application
    Filed: July 19, 2010
    Publication date: December 16, 2010
    Inventors: CHAITAN KHOSLA, LU SHAN
  • Diagnostic method for Celiac Sprue
    Patent number: 7776545
    Abstract: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: August 17, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Lu Shan
  • Scaleable Manufacturing Process for Cysteine Endoprotease B, Isoform 2
    Publication number: 20100196955
    Abstract: Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and purification processes, which processes may be combined with lyophilization to yield a stable product.
    Type: Application
    Filed: March 14, 2008
    Publication date: August 5, 2010
    Inventors: Harmit Vora, James McIntire, Pawan Kumar, Chaitan Khosla
  • Polyketides and antibiotics produced by combinatorial techniques
    Patent number: 7741456
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: June 22, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Camilla M. Kao
  • Recombinant methods and materials for producing epothilone and epothilone derivatives
    Patent number: 7732186
    Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: June 8, 2010
    Assignee: Kosan Biosciences, Inc.
    Inventors: Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang, Rainer Ziermann
  • Combination Enzyme Therapy for Digestion of Dietary Gluten
    Publication number: 20100092451
    Abstract: A combination enzyme product consisting of a glutamine specific endoprotease and a prolyl endopeptidase is provided. Both enzymes are active and stable in the stomach and can therefore be administered as lyophilized powders or simple capsules/tablets. A ratio of the two enzymes is used to maximize their synergy.
    Type: Application
    Filed: March 14, 2008
    Publication date: April 15, 2010
    Inventors: Jonathan David Gass, Chaitan Khosla, Michael Bethune, Matthew John Siegel
  • Design of polyketide synthase genes
    Patent number: 7680601
    Abstract: Methods for the computational analysis of polyketides and the computer-assisted design of PKS genes are facilitated by representing the structure of a polyketide and/or a PKS gene that encodes the PKS that produces the polyketide by alphanumeric symbols that facilitates computer assisted analysis. A database of polyketides and corresponding PKS genes that can be rapidly searched and information extracted for a variety of applications, including the design and specification of PKS genes via the recombining of modules or portions of modules or sets of modules from already known and available PKS genes.
    Type: Grant
    Filed: May 29, 2001
    Date of Patent: March 16, 2010
    Assignee: Kosan Biosciences
    Inventors: Chaitan Khosla, Ralph C. Reid, Daniel V. Santi, Michael A. Siani