Abstract: Various exemplary drug delivery devices with propellant, drug products utilizing the same, and methods of using drug delivery devices with propellant are provided. In general, a nasal drug delivery device is configured to expel a drug into a nose of a patient and to drive delivery of the drug using a propellant. The propellant includes a gas, e.g., air, carbon dioxide, etc., and/or at least one material substance configured to produce energy that causes movement of the drug out of an opening of the drug delivery device.

Abstract: A drug delivery device (400) comprises a tip (416) configured to be positioned in a nose of a patient, the tip having an opening (414) therein, a coupling mechanism (402) configured to releasably couple to a first vial (404) containing a first drug therein, to release the first vial therefrom, and to subsequently be releasably coupled to a second vial containing a second drug therein, and a plunger configured to be actuated to cause the first drug to exit through the opening and to be subsequently actuated to cause the second drug to exit through the opening. The same drug delivery device is therefore configured to deliver multiple doses. There are also disclosed various exemplary reloadable drug vials for multi-dose delivery, drug products utilizing the same, and methods of using reloadable drug vials for multi-dose delivery.

Abstract: Various exemplary drug delivery devices with a mechanical stop, drug products utilizing the same, and methods of using drug delivery devices with a mechanical stop are provided. In general, a nasal drug delivery device is configured to dispense therefrom first and second doses of a drug therefrom into a nose. The drug delivery device includes a mechanical stop configured to provide a pause between the delivery of the first and second doses. During the pause, a user of the drug delivery device can move the drug delivery device from one nostril, into which the first dose was sprayed, to another nostril, into which the second dose can be sprayed. The mechanical stop is configured to hold the drug delivery device in a static delivery state.

Abstract: Drug delivery systems and methods are provided for monitoring and/or tracking exposure of a drug to one or more conditions that can affect performance of the drug.