Patents by Inventor Challice L. Bonifant

Challice L. Bonifant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC ANTIGEN RECEPTORS TARGETING ABNORMAL GLYCOBIOLOGY
    Publication number: 20240124548
    Abstract: The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.
    Type: Application
    Filed: August 1, 2023
    Publication date: April 18, 2024
    Inventors: Challice L. Bonifant, Alnawaz Rehemtulla, David M. Markovitz
  • Chimeric antigen receptors targeting abnormal glycobiology
    Patent number: 11760786
    Abstract: The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: September 19, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Challice L. Bonifant, Alnawaz Rehemtulla, David M. Markovitz
  • CHIMERIC ANTIGEN RECEPTORS TARGETING ABNORMAL GLYCOBIOLOGY
    Publication number: 20200247868
    Abstract: The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.
    Type: Application
    Filed: February 5, 2020
    Publication date: August 6, 2020
    Inventors: Challice L. Bonifant, Alnawaz Rehemtulla, David M. Markovitz