Patents by Inventor Chamsy Sarkis

Chamsy Sarkis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transient expression vectors, preparation and uses thereof
    Patent number: 10308955
    Abstract: The present invention describes a recombinant retroviral vector which cannot by itself achieve complete reverse transcription as well as its uses, in particular for transiently transferring in vitro, ex vivo or in vivo at least one ribonucleic acid sequence of interest in a cell. Such a transient transgene expression is of interest in the context of research, therapy and more generally in the field of biotechnology.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: June 4, 2019
    Assignee: NEWVECTYS
    Inventors: Chamsy Sarkis, Dorothee Altemir, Nicolas Grandchamp, Stephanie Philippe
  • TRANSIENT EXPRESSION VECTORS, PREPARATION AND USES THEREOF
    Publication number: 20140286907
    Abstract: The present invention describes a recombinant retroviral vector which cannot by itself achieve complete reverse transcription as well as its uses, in particular for transiently transferring in vitro, ex vivo or in vivo at least one ribonucleic acid sequence of interest in a cell. Such a transient transgene expression is of interest in the context of research, therapy and more generally in the field of biotechnology.
    Type: Application
    Filed: October 26, 2012
    Publication date: September 25, 2014
    Inventors: Chamsy Sarkis, Dorothee Altemir, Nicolas Grandchamp, Stephanie Philippe
  • TRANSGENIC PIG FOR MUTANT GUCY2D AS CONE DYSTROPHY MODEL
    Publication number: 20140033333
    Abstract: The present invention relates to a transgenic pig as a model for studying a cone affecting disease, in particular a cone dystrophy or cone-rod-dystrophy, wherein the pig model expresses a dominant negative guanylate-cyclase-2D (GUCY2D) protein, in particular a GUCY2D protein comprising at least one mutation responsible for the appearance of a CORD6 cone dystrophy in a human being. The invention further relates to methods by which the transgenic pig is produced, to uses of said transgenic pig or of one of its elements to identify new biomarkers of a cone affecting disease and/or new compounds for preventing or treating such a disease. Novel methods for preventing or treating a cone affecting disease or for evaluating conditions needed to alleviate such a disease are further herein described.
    Type: Application
    Filed: January 27, 2012
    Publication date: January 30, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASILE DES AVEUGLES
    Inventors: Chamsy Sarkis, Christopher Bruce Alexander Whitelaw, Simon Lillico, Corinne Kostic, Yvan Arsenijevic
  • Non-integrative and non-replicative lentivirus, preparation and uses thereof
    Patent number: 8119119
    Abstract: The invention concerns a non-integrative and non-replicative recombinant lentivirus as well as its uses, in particular for preparing a composition for transferring genes in vitro, ex vivo or in vivo. The invention is useful for transferring genes in any mammal organism, for example in liver, muscle, pancreas or central nervous system (including the ocular sphere) tissues or cells, and in particular for treating disorders or pathologies such as, for example, central nervous system, including the ocular sphere, disorders.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: February 21, 2012
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jacques Mallet, Che Serguera, Stéphanie Philippe, Chamsy Sarkis
  • Methods of gene transfer to astrocytes with mokola virus pseudotyped lentivirus vectors
    Patent number: 7749973
    Abstract: The invention relates to a defective lentivirus which is pseudotyped with a lyssavirus envelope of the PV (rabies virus) or MOK type (Mokola virus), for example, and to the use thereof, especially in the preparation of a composition for in vivo transfer of genes in astrocytes and also for the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: July 6, 2010
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Chamsy Sarkis, Yi He, Che Serguera, Noelle Dufour, Jacques Mallet
  • Vectors derived from baculovirus and use for transferring nucleic acids into nerve cells of vertebrates
    Patent number: 7018628
    Abstract: The invention concerns novel recombinant viruses and their use for gene-transfer into nerve cells of vertebrates. The invention also concerns pharmaceutical compositions comprising said recombinant viruses. More particularly, the invention concerns novel vectors derived from baculoviruses and their use for treating diseases of the nervous system of vertebrates.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: March 28, 2006
    Assignee: Aventis Pharma S.A.
    Inventors: Chamsy Sarkis, Jacques Mallet
  • Pseudotyping vih-1 vectors with the aid of rhabdovirus envelopes
    Publication number: 20040120929
    Abstract: The invention relates to a defective lentivirus which is pseudotyped with a lyssavirus envelope of the PV (rabies virus) or MOK type (Mokola virus), for example, and to the use thereof, especially in the preparation of a composition for in vivo transfer of genes in astrocytes and also for the treatment of disorders of the central nervous system.
    Type: Application
    Filed: February 12, 2004
    Publication date: June 24, 2004
    Inventors: Chamsy Sarkis, Yi He, Che Serguera, Noelle Dufour, Jacques Mallet