Patents by Inventor Chan DING

Chan DING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composite multi-epitope expression cassette, a recombinant virus composed thereof and application thereof
    Patent number: 11305007
    Abstract: The present application relates a composite multi-epitope expression cassette, a recombinant virus composed thereof and application thereof, and in particular to a chimeric recombinant Newcastle disease virus inserted with an IBV epitope cassette and a vaccine prepared by using the virus. The expression cassette comprises: (a) T cell epitopes derived from S1 proteins of avian infectious bronchitis virus Holte strain and avian infectious bronchitis virus QX-like strain; and (b) B cell epitopes derived from S1 protein of avian infectious bronchitis virus Australian T strain. In the present application, the multi-epitope chimeric ST/B gene of avian infectious bronchitis virus is inserted into the backbone of LaSota strain, so that the LaSota strain can express S1-T/B protein. Thus, the purpose of preventing both ND and IB diseases is achieved. In addition, the T cell epitopes and B cell epitopes act synergistically to produce an earlier and more comprehensive immune response against virus.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: April 19, 2022
    Assignee: SHANGHAI VETERINARY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES (NATIONAL CENTER FOR ANIMAI HEALTH SHANGHAI)
    Inventors: Chan Ding, Huabin Shao, Lei Tan, Guoyuan Wen, Shengqing Yu, Xusheng Qiu, Ying Liao, Chunchun Meng, Yingjie Sun, Cuiping Song
  • A COMPOSITE MULTI-EPITOPE EXPRESSION CASSETTE, A RECOMBINANT VIRUS COMPOSED THEREOF AND APPLICATION THEREOF
    Publication number: 20210338802
    Abstract: The present application relates a composite multi-epitope expression cassette, a recombinant virus composed thereof and application thereof, and in particular to a chimeric recombinant Newcastle disease virus inserted with an IBV epitope cassette and a vaccine prepared by using the virus. The expression cassette comprises: (a) T cell epitopes derived from S1 proteins of avian infectious bronchitis virus Holte strain and avian infectious bronchitis virus QX-like strain; and (b) B cell epitopes derived from S1 protein of avian infectious bronchitis virus Australian T strain. In the present application, the multi-epitope chimeric ST/B gene of avian infectious bronchitis virus is inserted into the backbone of LaSota strain, so that the LaSota strain can express S1-T/B protein. Thus, the purpose of preventing both ND and IB diseases is achieved. In addition, the T cell epitopes and B cell epitopes act synergistically to produce an earlier and more comprehensive immune response against virus.
    Type: Application
    Filed: January 21, 2019
    Publication date: November 4, 2021
    Inventors: Chan DING, Huabin SHAO, Lei TAN, Guoyuan WEN, Shengqing YU, Xusheng QIU, Ying LIAO, Chunchun MENG, Yingjie SUN, Cuiping SONG