Abstract: Provided are a compound capable of degrading a target protein using ubiquitin and having a targeted protein binding moiety (TBM) structure binding to a target protein or polypeptide and a ubiquitin binding moiety (UBM) structure to which ubiquitin is bound, wherein the compound can be induced to polyubiquitination by the UBM structure present in the compound, and thus have an advantage of becoming a protein degrader capable of degrading a target protein or polypeptide.

Abstract: An engine ignition timing control method includes: acquiring, by an engine control unit (ECU), intake air humidity of an engine using a humidity sensor; calculating, by the ECU, an amount of first ignition timing correction based on the intake air humidity and an EGR rate; calculating, by the ECU, an amount of second ignition timing correction based on an engine operation region; and correcting, by the ECU, ignition timing of the engine using the amount of first ignition timing correction and the amount of second ignition timing correction.

Abstract: An engine ignition timing control method includes: acquiring, by an engine control unit (ECU), intake air humidity of an engine using a humidity sensor; calculating, by the ECU, an amount of first ignition timing correction based on the intake air humidity and an EGR rate; calculating, by the ECU, an amount of second ignition timing correction based on an engine operation region; and correcting, by the ECU, ignition timing of the engine using the amount of first ignition timing correction and the amount of second ignition timing correction.

Abstract: Disclosed herein are an emergency operating system and an emergency operating method for a hybrid vehicle with a damaged bearing of an engine, which are capable of preventing a bearing from being further damaged due to a drive motor and a hybrid starter and generator (HSG) when damage to the bearing installed in an engine is detected and capable of driving the hybrid vehicle and which include a bearing damage detection operation, an engine driving maintaining operation, a first state of charge (SOC) comparison operation, and a first emergency operating operation.