Abstract: Disclosed herein are compositions and methods that involve using compositions containing one or more of ETV2, FOXC2, FLI1 and a miR-200b inhibitor for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.

Abstract: Disclosed herein are compositions and methods that involve using compositions containing one or more of ETV2, FOXC2, FLI1 and a miR-200b inhibitor for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.

Abstract: Disclosed and described herein are systems and methods of energy generation from fabric electrochemistry. An electrical cell is created when electrodes (cathodes and anodes) are ‘printed’ on or otherwise embedded into fabrics to generate DC power when moistened by a conductive bodily liquid such as sweat, wound, fluid, etc. The latter acts, in turn, as the cell's electrolyte. A singular piece of fabric can be configured into multiple cells by dividing regions of the fabric with hydrophobic barriers and having at least one anode-cathode set in each region. Flexible inter-connections between the cells can be used to scale the generated power, per the application requirements.

Abstract: Provided herein are devices and methods for topically and controllably delivering cargo or collecting samples into or from biological tissues, particularly the skin. These devices permit delivery of cargo and collection of samples from cell layers deep within a tissue. These devices include microstructure arrays comprising nanochannels. Also disclosed is a device comprising a one or more microstructure arrays encased in a frame.

Abstract: Provided herein are devices and methods for topically and controllably delivering cargo across or into biological tissues, particularly the skin. These devices permit delivery of cargo to deeper cell layers of a tissue. These devices include microstructure arrays comprising nanochannels. Also disclosed is a device comprising a one or more microstructure arrays encased in a frame.

Abstract: Disclosed herein are compositions and methods that involve using compositions for directly reprogramming skin cells into insulin-producing cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the treatment of insulin-dependent and insulin-resistant diabetes. Therefore, also disclosed is a method for treating diabetes in a subject that involves reprogramming an effective amount of skin cells in the subject into an insulin producing cell using the method disclosed herein.

Abstract: Disclosed are lung-targeted extracellular vesicles (EVs) loaded with an anti-inflammatory cargo, as well as compositions, systems, and methods for making same. The disclosed EVs can contain a lung targeted ligand, such as a fusion protein containing a lung targeting moiety. Also disclosed is a composition comprising an EV containing the disclosed fusion protein. In some embodiments, the EV is loaded with an anti-inflammatory cargo. Also disclosed is an EV-producing cell engineered to produce the disclosed EVs. Also disclosed is a method for making the disclosed EVs that involves culturing the disclosed EV-producing cells under conditions suitable to produce EVs.

Abstract: A system for accelerating the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells. The system of the present invention accelerates the healing of wounds by electrotaxis of cells.

Abstract: Disclosed herein are compositions and methods for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.

Abstract: Disclosed and described herein are systems and methods energy generation from fabric electrochemistry. An electrical cell is created when electrodes (cathodes and anodes) are ‘printed’ on or otherwise embedded into fabrics to generate DC power when moistened by a conductive bodily liquid such as sweat, wound, fluid, etc. The latter acts, in turn, as the cell's electrolyte. A singular piece of fabric can be configured into multiple cells by dividing regions of the fabric with hydrophobic barriers and having at least one anode-cathode set in each region. Flexible inter-connections between the cells can be used to scale the generated power, per the application requirements.

Abstract: The present disclosure relates to topical tocotrienol compositions, dosing regimens, and methods for increasing the stem cell content of the skin. The present invention further relates to topical tocotrienol compositions, dosing regimens, and methods for the treatment of skin disorders.

Abstract: Provided herein are devices and methods for topically and controllably delivering cargo across or into biological tissues, particularly the skin. These devices permit delivery of cargo to deeper cell layers of a tissue. These devices include microstructure arrays comprising nanochannels. Also disclosed is a device comprising a one or more microstructure arrays encased in a frame.

Abstract: Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.

Abstract: The present invention provides methods to improve scar and burn outcome utilizing tocotrienols. In particular, various skin pathologies may be treated using the present methods. The present invention also provides methods to increase skin tissue concentrations of tocotrienols.

Abstract: Methods and compositions for modulating JNK activity and stimulating efferocytosis in a cell or patient are described. Therapeutic modified collagens comprising a plurality of proteins characterized by Table 1 for use as JNK modulators are also described.

Abstract: A system for accelerating the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells. The system of the present invention accelerates the healing of wounds by electrotaxis of cells.

Abstract: A method for accelerating the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells. The method of the present invention accelerates the healing of wounds by electrotaxis of cells.

Abstract: An apparatus and method for accelerating the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells. The apparatus and method of the present invention accelerates the healing of wounds by electrotaxis of cells. The present invention is directed to an apparatus and method of accelerating the healing of wounds by subjecting the wound to an electric field.

Abstract: The present invention provides methods to improve scar and burn outcome utilizing tocotrienols. In particular, various skin pathologies may be treated using the present methods. The present invention also provides methods to increase skin tissue concentrations of tocotrienols.

Abstract: The present invention provides methods of promoting arteriogenesis in a subject. Embodiments include methods comprising: administering an effective dose of tocotrienol to the subject; causing an increase in Tissue Inhibitor of Metalloproteinase Metallopeptidase Inhibitor 1 (TIMP1) in vessels of cerebrovascular collateral circulation in the subject; attenuating the activity of Matrix Metalloproteinase-2 (MMP2); thereby promoting arteriogenesis.