Patents by Inventor Chandra M. Sehgal

Chandra M. Sehgal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11071517
    Abstract: A method for ultrasound diagnosis includes determining a first risk of malignancy based on a human assessment of a first set of features of one or more ultrasound images of a target; determining a second risk of malignancy based on an automatically extracted second set of features of the one or more ultrasound images; determining at least one overall risk value based on the first risk of malignancy and the second risk of malignancy; and characterizing the at least one overall risk value as one of a high confidence assessment or a low confidence assessment.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: July 27, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Chandra M. Sehgal, Santosh S. Venkatesh, Laith R. Sultan
  • Patent number: 11065348
    Abstract: A microfluidic device for generating microbubbles includes a substrate and a microfluidic channel embedded in the substrate. The microfluidic channel includes a plurality of fluid inlets, at least one bubble formation outlet having a nozzle with an adjustable diameter, and a flow focusing junction in fluid communication with the plurality of fluid inlets and the bubble formation outlet. A method for mass producing monodisperse microbubbles with a microfluidic device includes supplying a flow of dispersed phase fluid into a first fluid inlet of a microfluidic channel, supplying a flow of continuous phase fluid into a second fluid inlet of the microfluidic channel, and adjusting a diameter of a nozzle to obtain a plurality of monodisperse microbubbles having a specified diameter.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: July 20, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Daeyeon Lee, Francesco Angile, Kevin Vargo, Daniel A. Hammer, Chandra M. Sehgal
  • Publication number: 20200394798
    Abstract: A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape.
    Type: Application
    Filed: August 24, 2020
    Publication date: December 17, 2020
    Inventors: Benjamin M. Jackson, Robert C. Gorman, Joseph H. Gorman, III, Alison M. Pouch, Chandra M. Sehgal, Paul A. Yushkevich, Brian B. Avants, Hongzhi Wang
  • Patent number: 10783631
    Abstract: A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: September 22, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Benjamin M. Jackson, Robert C. Gorman, Joseph H. Gorman, III, Alison M. Pouch, Chandra M. Sehgal, Paul A. Yushkevich, Brian B. Avants, Hongzhi Wang
  • Publication number: 20190213737
    Abstract: A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape.
    Type: Application
    Filed: March 15, 2019
    Publication date: July 11, 2019
    Inventors: Benjamin M. Jackson, Robert C. Gorman, Joseph H. Gorman, III, Alison M. Pouch, Chandra M. Sehgal, Paul A. Yushkevich, Brian B. Avants, Hongzhi Wang
  • Patent number: 10235754
    Abstract: A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: March 19, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Benjamin M. Jackson, Robert C. Gorman, Joseph H. Gorman, Alison M. Pouch, Chandra M. Sehgal, Paul A. Yushkevich, Brian B. Avants, Hongzhi Wang
  • Publication number: 20170365057
    Abstract: A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape.
    Type: Application
    Filed: September 6, 2017
    Publication date: December 21, 2017
    Inventors: Benjamin M. Jackson, Robert C. Gorman, Joseph H. Gorman, Alison M. Pouch, Chandra M. Sehgal, Paul A. Yushkevich, Brian B. Avants, Hongzhi Wang
  • Patent number: 9779496
    Abstract: A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: October 3, 2017
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Benjamin M. Jackson, Robert C. Gorman, Joseph H. Gorman, Alison M. Pouch, Chandra M. Sehgal, Paul A. Yushkevich, Brian B. Avants, Hongzhi Wang
  • Publication number: 20170140124
    Abstract: A method for ultrasound diagnosis includes determining a first risk of malignancy based on a human assessment of a first set of features of one or more ultrasound images of a target; determining a second risk of malignancy based on an automatically extracted second set of features of the one or more ultrasound images; determining at least one overall risk value based on the first risk of malignancy and the second risk of malignancy; and characterizing the at least one overall risk value as one of a high confidence assessment or a low confidence assessment.
    Type: Application
    Filed: November 2, 2016
    Publication date: May 18, 2017
    Applicant: The Trustees of The University of Pennsylvania
    Inventors: Chandra M. Sehgal, Santosh S. Venkatesh, Laith R. Sultan
  • Publication number: 20170119911
    Abstract: A microfluidic device for generating mi-crobubbles includes a substrate and a microfluidic channel embedded in the substrate. The microfluidic channel includes a plurality of fluid inlets, at least one bubble formation outlet having a nozzle with an adjustable diameter, and a flow focusing junction in fluid communication with the plurality of fluid inlets and the bubble formation outlet. A method for mass producing monodisperse microbubbles with a microfluidic device includes supplying a flow of dispersed phase fluid into a first fluid inlet of a microfluidic channel, supplying a flow of continuous phase fluid into a second fluid inlet of the microfluidic channel, and adjusting a diameter of a nozzle to obtain a plurality of monodisperse microbubbles having a specified diameter.
    Type: Application
    Filed: June 19, 2015
    Publication date: May 4, 2017
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Daeyeon LEE, Francesco ANGILE, Kevin VARGO, Daniel A. HAMMER, Chandra M. SEHGAL
  • Patent number: 9406142
    Abstract: A fully automatic method for segmentation of the mitral leaflets in 3D transesophageal echocardiographic (3D TEE) images is provided. The method combines complementary probabilistic segmentation and geometric modeling techniques to generate 3D patient-specific reconstructions of the mitral leaflets and annulus from 3D TEE image data with no user interaction. In the model-based segmentation framework, mitral leaflet geometry is described with 3D continuous medial representation (cm-rep). To capture leaflet geometry in a target 3D TEE image, a pre-defined cm-rep template of the mitral leaflets is deformed such that the negative log of a Bayesian posterior probability is minimized. The likelihood of the objective function is given by a probabilistic segmentation of the mitral leaflets generated by multi-atlas joint label fusion, while the validity constraints and regularization terms imposed by cm-rep act as shape priors that preserve leaflet topology and constrain model fitting.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: August 2, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Joseph H. Gorman, III, Alison M. Pouch, Robert C. Gorman, Hongzhi Wang, Paul Yushkevich, Benjamin M Jackson, Brian B. Avants, Chandra M. Sehgal
  • Publication number: 20160035087
    Abstract: A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 4, 2016
    Inventors: Benjamin M. Jackson, Robert C. Gorman, Joseph H. Gorman, Alison M. Pouch, Chandra M. Sehgal, Paul A. Yushkevich, Brian B. Avants, Hongzhi Wang
  • Publication number: 20150178938
    Abstract: A fully automatic method for segmentation of the mitral leaflets in 3D transesophageal echocardiographic (3D TEE) images is provided. The method combines complementary probabilistic segmentation and geometric modeling techniques to generate 3D patient-specific reconstructions of the mitral leaflets and annulus from 3D TEE image data with no user interaction. In the model-based segmentation framework, mitral leaflet geometry is described with 3D continuous medial representation (cm-rep). To capture leaflet geometry in a target 3D TEE image, a pre-defined cm-rep template of the mitral leaflets is deformed such that the negative log of a Bayesian posterior probability is minimized. The likelihood of the objective function is given by a probabilistic segmentation of the mitral leaflets generated by multi-atlas joint label fusion, while the validity constraints and regularization terms imposed by cm-rep act as shape priors that preserve leaflet topology and constrain model fitting.
    Type: Application
    Filed: October 8, 2014
    Publication date: June 25, 2015
    Inventors: JOSEPH H. GORMAN, III, ALISON M. POUCH, ROBERT C. GORMAN, HONGZHI WANG, PAUL YUSHKEVICH, BENJAMIN M. JACKSON, BRIAN B. AVANTS, CHANDRA M. SEHGAL
  • Publication number: 20120328529
    Abstract: A method for generating stable encapsulated bubbles and dried encapsulated bubbles comprises introducing an inner stream of a gas into a liquid-filled chamber from an exit orifice of a capillary tube; introducing a middle stream of a water immiscible liquid into the exit orifice; and introducing an outer stream of an aqueous liquid to the exit orifice, to form compound bubbles. The encapsulated bubbles are formed after converting the middle phase of compound bubbles into a shell. The stable encapsulated bubbles or the stable dried encapsulated bubbles can be used in drug delivery and for enhancing ultrasound imaging.
    Type: Application
    Filed: August 5, 2010
    Publication date: December 27, 2012
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Daeyeon Lee, Chandra M. Sehgal, Myung Han Lee
  • Patent number: 6858011
    Abstract: Methods and apparatus are provided for controlling fluid flow or perfusion, wherein gas-filled microbubbles are used as ultrasound contrast-enhancing agents, and wherein the method comprises separating the removal of the contrast agent due to flow from the removal of the contrast agent due to bubble destruction for enhanced imaging processes. By varying exposure of the microbubbles to ultrasound, the method and apparatus apply the changes observed in the images to measure flow and vascularity, to improve visualization of blood flow and blood vessels, and to guide delivery of drugs locally to the site of imaging.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: February 22, 2005
    Assignee: Trustees of the University of Pennsylvania
    Inventor: Chandra M. Sehgal
  • Publication number: 20030092991
    Abstract: Methods and apparatus are provided for controlling fluid flow or perfusion, wherein gas-filled microbubbles are used as ultrasound contrast-enhancing agents, and wherein the method comprises separating the removal of the contrast agent due to flow from the removal of the contrast agent due to bubble destruction for enhanced imaging processes. By varying exposure of the microbubbles to ultrasound, the method and apparatus apply the changes observed in the images to measure flow and vascularity, to improve visualization of blood flow and blood vessels, and to guide delivery of drugs locally to the site of imaging.
    Type: Application
    Filed: September 23, 2002
    Publication date: May 15, 2003
    Inventor: Chandra M. Sehgal