Patents by Inventor Chandra Ulagaraj Singh
Chandra Ulagaraj Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200000753Abstract: The present invention provides methods and compositions for the treatment of neuropathic pain. In certain embodiments, compositions comprising an dextromethorphan (or other N-methyl-D-aspartate receptor antagonist), tramadol, and gabapentin can synergistically act to reduce pain in a human patient. Pharmaceutical compositions may also comprise a capsaicinoid, an esterified capsaicinoid, and/or a tricyclic antidepressant.Type: ApplicationFiled: May 8, 2019Publication date: January 2, 2020Inventor: Chandra Ulagaraj Singh
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Patent number: 10300031Abstract: The present invention provides methods and compositions for the treatment of neuropathic pain. In certain embodiments, compositions comprising an dextromethorphan (or other N-methyl-D-aspartate receptor antagonist), tramadol, and gabapentin can synergistically act to reduce pain in a human patient. Pharmaceutical compositions may also comprise a capsaicinoid, an esterified capsaicinoid, and/or a tricyclic antidepressant.Type: GrantFiled: August 6, 2008Date of Patent: May 28, 2019Assignee: Trinity Laboratories Inc.Inventor: Chandra Ulagaraj Singh
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Patent number: 9993454Abstract: The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry. The present invention provides novel pharmaceutical compositions composed of solid nanoparticles dispersed in aqueous medium of substantially water insoluble pharmaceutical substances such as docetaxel with reduced Ostwald ripening.Type: GrantFiled: May 15, 2014Date of Patent: June 12, 2018Assignee: Luminus Biosciences, Inc.Inventor: Chandra Ulagaraj Singh
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Publication number: 20160367514Abstract: The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry. The present invention provides novel pharmaceutical compositions composed of solid nanoparticles dispersed in aqueous medium of substantially water insoluble pharmaceutical substances such as docetaxel with reduced Ostwald ripening.Type: ApplicationFiled: May 15, 2014Publication date: December 22, 2016Applicant: LUMINUS BIOSCIENCES, INC.Inventor: Chandra Ulagaraj Singh
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Patent number: 8987328Abstract: Provided are nutraceutical or dietary supplemental compositions comprising esterified capsaicinoids. The esterified capsaicinoids may converted to the active parent capsaicinoid compound following enzymatic or chemical hydrolysis. In various embodiments, these esterified capsaicinoids have a higher lipophilicity, lipid solubility and result in less irritation to the stomach than the parent capsaicinoid, and hence may be included in certain dietary supplement formulations, including capsules, pills and tablets dietary supplement formulations. The dietary supplement compositions may be used for pain management in mammals in vivo and/or in the treatment of various pathological conditions in humans.Type: GrantFiled: October 30, 2009Date of Patent: March 24, 2015Assignee: Trinity Laboratories, Inc.Inventors: Chandra Ulagaraj Singh, Rao Nulu Jagaveerabhadra
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Patent number: 8765807Abstract: The present invention relates to the formulations of ester derivatives of capsaicin and ester derivatives of myristoleic acid. These derivatives are capable of reverting to the active parent compound following enzymatic or chemical hydrolysis. These derivatives have a higher lipophilicity, lipid solubility and less irritation to the skin than the parent compound, and hence are better able to be incorporated into certain pharmaceutical formulations, including cream and ointment pharmaceutical formulations. The pharmaceutical compositions are useful for pain management in mammals in vivo and have been contemplated to be used in the treatment of various pains in humans.Type: GrantFiled: May 16, 2011Date of Patent: July 1, 2014Assignee: Trinity Laboratories, Inc.Inventors: Chandra Ulagaraj Singh, Jagaveerabhadra Rao Nulu
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Patent number: 8728527Abstract: The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry. The present invention provides novel pharmaceutical compositions composed of solid nanoparticles dispersed in aqueous medium of substantially water insoluble pharmaceutical substances such as docetaxel with reduced Ostwald ripening.Type: GrantFiled: July 24, 2007Date of Patent: May 20, 2014Assignee: Luminus Biosciences, Inc.Inventor: Chandra Ulagaraj Singh
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Publication number: 20130289102Abstract: The present invention relates to formulations comprising amyris alcohol or an ester of amyris alcohol or combinations thereof to treat acne in humans. These formulations can further comprise a phytoestrogen such as glabridin and miroestrol, an antioxidant such as tetrahydrocurcumin and naturally occurring peroxides such as artemisinin and dihydroartemisinin and combinations thereof for improved effectiveness in treating acne.Type: ApplicationFiled: December 22, 2011Publication date: October 31, 2013Applicant: Trinity Laboratories, Inc.Inventors: Chandra Ulagaraj Singh, Jagaveerabhadra Rao Nulu
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Publication number: 20130225627Abstract: The invention provides orally administered antitussive pharmaceutical compositions comprising dextromethorphan, wherein the compositions are free of bromide, sodium and polistirex.Type: ApplicationFiled: August 1, 2011Publication date: August 29, 2013Applicant: Trinity Laboratories, Inc.Inventors: Chandra Ulagaraj Singh, Jagaveerabhadra Rao Nulu
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Publication number: 20110218180Abstract: The present invention relates to the formulations of ester derivatives of capsaicin and ester derivatives of myristoleic acid. These derivatives are capable of reverting to the active parent compound following enzymatic or chemical hydrolysis. These derivatives have a higher lipophilicity, lipid solubility and less irritation to the skin than the parent compound, and hence are better able to be incorporated into certain pharmaceutical formulations, including cream and ointment pharmaceutical formulations. The pharmaceutical compositions of the present invention contain a compound of following formula (Ia): R—CO—CAP??(Ia) wherein CAP refers to collectively the capsaicins represented in FIG. 1 and a compound of formula (Ib): MCO—O—R??(Ib) wherein MCO refers to myristoleic acid.Type: ApplicationFiled: May 16, 2011Publication date: September 8, 2011Applicant: Trinity Laboratiories, Inc.Inventors: Chandra Ulagaraj Singh, Jagaveerabhadra Rao Nulu
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Patent number: 7943666Abstract: The present invention relates to the formulations of ester derivatives of capsaicin and ester derivatives of myristoleic acid. These derivatives are capable of reverting to the active parent compound following enzymatic or chemical hydrolysis. These derivatives have a higher lipophilicity, lipid solubility and less irritation to the skin than the parent compound, and hence are better able to be incorporated into certain pharmaceutical formulations, including cream and ointment pharmaceutical formulations. The pharmaceutical compositions of the present invention contain a compound of following formula (Ia): R—CO-CAP??(Ia) wherein CAP refers to collectively the capsaicins represented in FIG. 1 and a compound of formula (Ib): MCO-O—R??(Ib) wherein MCO refers to myristoleic acid.Type: GrantFiled: July 24, 2007Date of Patent: May 17, 2011Assignee: Trinity Laboratories, Inc.Inventors: Chandra Ulagaraj Singh, Jagaveerabhadra Rao Nulu
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Publication number: 20110039875Abstract: The present invention provides methods and compositions for the treatment of neuropathic pain. In certain embodiments, compositions comprising an dextromethorphan (or other N-methyl-D-aspartate receptor antagonist), tramadol, and gabapentin can synergistically act to reduce pain in a human patient. Pharmaceutical compositions may also comprise a capsaicinoid, an esterified capsaicinoid, and/or a tricyclic antidepressant.Type: ApplicationFiled: August 6, 2008Publication date: February 17, 2011Inventor: Chandra Ulagaraj Singh
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Patent number: 7858126Abstract: The present invention relates to the formulations of ester derivatives of sandalwood oil and santalol. These derivatives are capable of reverting to the active parent compound following enzymatic or chemical hydrolysis. These derivatives have a higher lipophilicity, lipid solubility and less irritation to the skin than the parent compound, and hence are better able to be incorporated into certain pharmaceutical formulations, including cream and ointment pharmaceutical formulations. The compounds of the present invention are set forth by the following formula: The present invention generally pertains to a compound of formula (I): R—CO—SWO??(I) wherein SWO refers to collectively the alcohols, including santalol, present in the sandalwood oil; wherein R is selected from alkyl groups of up to about 22 carbon atoms and aryl groups of up to about 22 carbon atoms and alkylene group of up to about 22 carbon atoms and an arylene group of up to about 22 carbon atoms.Type: GrantFiled: August 31, 2007Date of Patent: December 28, 2010Assignee: Trinity Laboratories Inc.Inventors: Chandra Ulagaraj Singh, Jagaveerabhadra Rao Nulu
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Publication number: 20100120907Abstract: Provided are topical formulations comprising an Amyris alcohol and/or ester derivatives of Amyris alcohol which may be used for the treatment of diseases including herpes virus infection (e.g., HSV-1, HSV-2), epidermoid carcinoma, cold sores, and human papillomavirus. Amyris alcohols contemplated for use with the present invention include valerianol, beta-eudesmol, epi-gamma-eudesmol, elemol, alpha-eudesmol, and ester derivatives thereof.Type: ApplicationFiled: April 18, 2008Publication date: May 13, 2010Inventors: Chandra Ulagaraj Singh, Rao Jagaveerabhadra Nulu
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Publication number: 20100120912Abstract: Provided are nutraceutical or dietary supplemental compositions comprising esterified capsaicinoids. The esterified capsaicinoids may converted to the active parent capsaicinoid compound following enzymatic or chemical hydrolysis. In various embodiments, these esterified capsaicinoids have a higher lipophilicity, lipid solubility and result in less irritation to the stomach than the parent capsaicinoid, and hence may be included in certain dietary supplement formulations, including capsules, pills and tablets dietary supplement formulations. The dietary supplement compositions may be used for pain management in mammals in vivo and/or in the treatment of various pathological conditions in humans.Type: ApplicationFiled: October 30, 2009Publication date: May 13, 2010Applicant: Trinity Laboratories Inc.Inventors: Chandra Ulagaraj Singh, Rao Nulu Jagaveerabhadra
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Publication number: 20100120780Abstract: Provided are methods and compositions for the treatment of a sexual dysfunction such as premature ejaculation. In certain embodiments, a NMDA antagonist (e.g., dextromethorphan) is administered to a subject in combination with tramadol or a tramadol derivative to treat premature ejaculation. In certain embodiments, a capsaicinoid (e.g., capsaicin) and/or a phosphodiesterase type V inhibitor (e.g., sildenafil citrate) are further administered to the subject. Pharmaceutical preparations such as tablets and capsules are provided.Type: ApplicationFiled: April 18, 2008Publication date: May 13, 2010Inventor: Chandra Ulagaraj Singh
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Patent number: 7645767Abstract: Chronic pain is alleviated in a mammal suffering there from by administering to the mammal a chronic pain alleviating amount of a nontoxic N-methyl-D-aspartate receptor antagonist such as dextromethorphan, dextrorphan, ketamine or pharmaceutically acceptable salt thereof, in combination with a ?-opiate analgesic such as tramadol or an analogously acting molecular entity, and a capsaicin or an ester of capsaicin, and optionally in sustained release dosage form.Type: GrantFiled: August 22, 2007Date of Patent: January 12, 2010Assignee: Trinity Laboratories, Inc.Inventors: Chandra Ulagaraj Singh, David Lloyd Woody, Jagaveerabhadra Rao Nulu
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Publication number: 20090238878Abstract: The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry. The present invention provides novel pharmaceutical compositions composed of solid nanoparticles dispersed in aqueous medium of substantially water insoluble pharmaceutical substances such as docetaxel with reduced Ostwald ripening.Type: ApplicationFiled: July 24, 2007Publication date: September 24, 2009Inventor: Chandra Ulagaraj Singh
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Publication number: 20080020996Abstract: The present invention relates to the formulations of ester derivatives of capsaicin and ester derivatives of myristoleic acid. These derivatives are capable of reverting to the active parent compound following enzymatic or chemical hydrolysis. These derivatives have a higher lipophilicity, lipid solubility and less irritation to the skin than the parent compound, and hence are better able to be incorporated into certain pharmaceutical formulations, including cream and ointment pharmaceutical formulations. The pharmaceutical compositions of the present invention contain a compound of following formula (Ia): R—CO-CAP ??(Ia) wherein CAP refers to collectively the capsaicins represented in FIG. 1 and a compound of formula (Ib): MCO-O—R ??(Ib) wherein MCO refers to myristoleic acid.Type: ApplicationFiled: July 24, 2007Publication date: January 24, 2008Inventors: Chandra Ulagaraj Singh, Jagaveerabhadra Rao Nulu