Abstract: The present invention provides heterocyclic compounds of formula (I), which are therapeutically useful as CBP/EP300 inhibitors. These compounds are useful in the treatment and/or prevention of diseases or disorders mediated by CBP and/or EP300 in an individual. The present invention also provides preparation of the compounds and pharmaceutical compositions comprising at least one of the compounds of formula (I) or a pharmaceutically acceptable salt, or a stereoisomer or a tautomer, an N-oxide or an ester thereof.

Abstract: A computer-implemented physics solver operates within a neural network framework. A neural network accepts a coordinate for each location within a design domain and outputs a local composition for each location. A model of the design domain is formed in a physics solver. The model includes discrete elements that encompass the design domain. A solution of the model provides a value of a design objective. For a plurality of iterations, the following is performed: the neural network determines current local compositions for the locations in the design domain corresponding to the discrete elements; the current local compositions are input into the discrete elements of the physics solver to obtain a current value of the design objective; and the current value of the design objective is used to find a loss gradient of a loss function. The loss gradient is used to update the neural network during the iterations.

Abstract: A network management system may discover a plurality of network devices behind a network address translation device, such as a firewall. The network management system may receive a model of N network devices, generate a bulk activation configuration for the N network devices and commit the bulk activation configuration on a seed network device. The network management system may receive a request for a first connection from a first neighboring network device and may connect to the first neighboring network device. The first neighboring network device may have received the bulk activation configuration from the seed device. The network management system may determine whether the first neighboring network device is one of the N network devices and commit a second activation configuration on the first neighboring network device if it is one of the N network devices. A plurality of neighboring network device may be configured in this fashion.

Abstract: A wireless transmission system included at least one user equipment and a base station. The base station is operable to form a downlink control information block, modulate the downlink control information, precode the modulated downlink control information, and transmit the precoded, modulated downlink control information on at least one demodulation reference signal antenna port to the at least one user equipment. The precoded, modulated downlink control information is mapped to a set of N1 physical resource block pairs in a subframe from an orthogonal frequency division multiplexing symbol T1 to and orthogonal frequency division multiplexing symbol T2.

Abstract: Implementations described herein relate to methods, systems, and computer-readable media to identify anomalous applications. In some implementations, the methods may include obtaining application metric data that includes application level metrics and instance level metrics for each instance of a plurality of instances associated with a respective application of a plurality of applications operating over a distributed computing system, generating a first anomaly detection score based on the instance level metrics; generating a second anomaly detection score based on one or more input metrics associated with the respective application, generating a third anomaly detection score based on seasonal metric data associated with the respective application and identifying at least one application of the plurality of applications as an anomalous application based on the first anomaly detection score, the second anomaly detection score, and the third anomaly detection score.

Abstract: A base station selects a subset of at least one geographically separated antennas for each of the plurality of user equipments. The base station forms at least layer of data stream including modulated symbols, precodes the data stream via multiplication with the NT-by-N precoding matrix where N is the number of said layers and NT is the number of transmit antenna elements and transmits the precoded layers of data stream to the user equipment via the selected geographically separated antennas. The base station signals the subset of the plurality of geographically separated antennas via higher layer Radio Resource Control or via a down link grant mechanism. The base station optionally does not signal the subset of the plurality of geographically separated antennas to the corresponding mobile user equipment.

Abstract: The disclosure relates to compounds of Formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.

Abstract: Network elements are managed with a server to support client data models from heterogeneous data sources. A server receives a first query for configuration data of a network element to be returned in a first model. The server determines a model type for the configuration data of the network element. When the model type is a second model that is not the first model, the server sends a second query to the network element for the configuration data to be returned in the second model and transforms the configuration data received from the network element into the first model. Additionally, the server returns the configuration data in the first model as a response to the first query.

Abstract: Implementations described herein relate to methods, systems, and computer-readable media to manage a computing resource allocation for a software application. In some implementations, a method may include receiving first metric data associated with the software application executing on a distributed computing system; determining, based on the first metric data, that an allocation of a computing resource for the software application is to be reduced from a first level of allocation; performing a mitigative check to determine a performance degradation likelihood score and reducing allocation of the computing resource to a third level that is lower than the first level based on a determination that the performance degradation likelihood score does not meet a threshold score.

Abstract: In one aspect, the present disclosure is directed to a method for preventing or treating a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a hyperimmunized egg product obtained from an egg-producing animal, thereby preventing or treating coronavirus infection in the subject, wherein the hyperimmunized egg product comprises a therapeutically effective amount of one or more antibodies to the coronavirus.

Abstract: An Information Handling System (IHS) includes at least one hardware device in communication with a Baseboard Management Controller (BMC). The hardware device includes executable instructions for establishing a secure communication channel with the BMC, and subsequently receiving a list of allowed commands from the BMC. When a command is received by the hardware device, it determines whether the command is included in the list such that when the command is in the list and the command is received within the secure communication channel, the hardware device performs the command. However, when the command is in the list and the command is received outside of the secure communication channel, the hardware device ignores the command.

Abstract: A TX-TX pre-compensation system that estimates unwanted coupling in a victim transmit chain caused by an aggressor transmit chain and injects a pre-compensation signal to cancel out the estimated coupling. In some embodiments, a signal measurement module estimates the amplitude, phase, and envelope delay of the coupling and an isolation pre-compensation module generates the pre-compensation signal based on the estimated amplitude, the estimated phase, the estimated envelope delay, and the difference between the carrier frequencies of the transmit chains. Since the phase of the coupling may be affected by the carrier frequency of the transmit chains, in some embodiments the phase of the pre-compensation signal is adjusted in response to a change in carrier frequency. Since the amplitude of the coupling may be affected by attenuator gain settings, in some embodiments the amplitude of the pre-compensation signal may be adjusted in response to a change in attenuator gain setting.

Abstract: A dry vaporizer, the dry vaporizer including a plurality of passages for accommodating a heating means each, at least two channels passing through the body wherein the channels are configured for passing a vaporized fluid, and a thermostat expansion valve configured to operate based on temperature of the body. The heating means are removable heaters placed in three passages of the body arranged in an equilateral triangle to enable equal heat distribution in the body and a method thereof.

Abstract: In one embodiment, a method is provided. The method comprises: validating data in a vehicle system database; identifying data to be collected from at least one vehicle system; validating sufficient data rights; if sufficient data rights are validated, collecting the identified data; identifying at least one analysis to be performed; performing the at least one analysis on the collected data; identifying at least one analysis report to be generated; and generating the at least one analysis report.

Abstract: An Information Handling System (IHS) includes multiple hardware devices, and a baseboard Management Controller (BMC) in communication with multiple hardware devices of the IHS. The BMC includes executable instructions for monitoring a parameter of one or more of the hardware devices when a custom BMC firmware stack is executed on the BMC. The instructions that monitor the parameter are separate and distinct from the instructions of the custom BMC firmware stack. The instructions also control the BMC to perform one or more operations to remediate an excessive parameter when the parameter exceeds a specified threshold.

Abstract: A computing device is provided. The computing device may include a first camera configured to capture a primary image sequence of a scene, and a second camera configured to substantially concurrently capture a secondary image sequence of the scene. The computing device may include a processor configured to execute instructions stored in memory to obtain a depth map for an image of the primary image sequence, and based on the depth map, generate a reference frame of background pixels from the primary image sequence. The processor may be configured to execute the instructions to detect an intrusive object in the secondary image sequence, replace the intrusive object in the primary image sequence with corresponding background pixels of the reference frame to generate a modified primary image sequence, and output on a display at least one image of the modified primary image sequence.

Abstract: A method, apparatus, system, and computer program product for processing an on-demand payroll request. In one illustrative example, an on-demand payroll microservice receives a request for an unscheduled payroll to an employee. The on-demand payroll microservice retrieves payroll information for the employee from a first set of microservices. The on-demand payroll microservice submits the payroll information to a second set of microservices for payroll calculations. In response to the second set of microservices completing the payroll calculations, the on-demand payroll microservice retrieves the payroll calculations through the first set of microservices. The on-demand payroll microservice displays the payroll calculations. In response to receiving approval of the unscheduled payroll, the on-demand payroll microservice submits the payroll calculations to the second set of microservices for payroll processing.

Abstract: Microelectronic assemblies, and related devices and methods, are disclosed herein. For example, in some embodiments, a microelectronic assembly may include a package substrate, a first die coupled to the package substrate with first interconnects, and a second die coupled to the first die with second interconnects, wherein the second die is coupled to the package substrate with third interconnects, a communication network is at least partially included in the first die and at least partially included in the second die, and the communication network includes a communication pathway between the first die and the second die.

Abstract: A ventilator apparatus includes a linear electro-mechanical actuator that interfaces with a self-inflating bag including an inlet configured to receive air and an outlet configured to expend the air. A three-way valve is coupled to the outlet via a first flowmeter, an ambient environment via a second flowmeter, and a patient via an endotracheal tube. The first and/or second flowmeters are coupled to pressure transducer(s). A control unit is coupled to the linear electro-mechanical actuator and the first and second flowmeters and includes a control panel, memory including programmed instructions stored thereon, and processor(s) configured to execute the stored programmed instructions to set an inhalation time and an exhalation time. A current inspiratory pressure and a current tidal volume are obtained from the pressure transducer(s) and/or the first flowmeter. A stroke of the linear electro-mechanical actuator is then controlled to facilitate inspiratory and expiratory phases of a respiratory cycle.

Abstract: A method by a wearable device is described. The method includes receiving geometric information from a controller. The geometric information includes a point cloud and a key frame of the controller. The method also includes receiving first six degree of freedom (6DoF) pose information from the controller. The method further includes synchronizing a coordinate system of the wearable device with a coordinate system of the controller based on the point cloud and the key frame of the controller. The method additionally includes rendering content in an application based on the first 6DoF pose information.