Abstract: Systems and methods according to one or more embodiments are provided for a hum reduction circuit implemented to provide a ground path between an audio generating device and a powered headset. In one example, a system includes a jack configured to accept a plug comprising a first electrical ground connection. The system also includes a switch coupled to the jack at a first end and coupled to second electrical ground connection at a second end. The system also includes the switch is configured to couple to the first electrical ground at the first end. The system further includes a bias control signal coupled to the switch, configured to control a switch bias, where a first switch bias electrically couples the first electrical ground to the second electrical ground, and a second switch bias electrically decouples the first electrical ground from the second electrical ground.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: Systems and methods according to one or more embodiments are provided for a hum reduction circuit implemented to provide a ground path between an audio generating device and a powered headset. In one example, a system includes a jack configured to accept a plug comprising a first electrical ground connection. The system also includes a switch coupled to the jack at a first end and coupled to second electrical ground connection at a second end. The system also includes the switch is configured to couple to the first electrical ground at the first end. The system further includes a bias control signal coupled to the switch, configured to control a switch bias, where a first switch bias electrically couples the first electrical ground to the second electrical ground, and a second switch bias electrically decouples the first electrical ground from the second electrical ground.

Abstract: A system that utilizes an amplified signal is disclosed that includes a plurality of first switches coupled to a plurality of first impedances. A plurality of second switches coupled to a plurality of second impedances. An amplifier having a first input coupled to the plurality of first switches and a second input coupled to the plurality of second switches. A leakage current offset source coupled to the first input of the amplifier, wherein the leakage current offset source cancels a leakage current component of a first current provided from the plurality of first switches to the first input.

Abstract: A system that utilizes an amplified signal is disclosed that includes a plurality of first switches coupled to a plurality of first impedances. A plurality of second switches coupled to a plurality of second impedances. An amplifier having a first input coupled to the plurality of first switches and a second input coupled to the plurality of second switches. A leakage current offset source coupled to the first input of the amplifier, wherein the leakage current offset source cancels a leakage current component of a first current provided from the plurality of first switches to the first input.

Abstract: A system is provided that invokes an external web service using a composite application. The system creates a composite application definition, where the composite application definition includes external web service information and a mapping of a task operation to a service operation. The system further dynamically generates the composite application based on the composite application definition, where the composite application includes computer code. The system further deploys the composite application.

Abstract: The present invention provides substituted pyridine derivatives of formula (I), which may be therapeutically useful as as anti-bacterial agents, more particularly FabI inhibitors. Formula (I) in which R1 to R5 and L have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage anti-bacterial agents, more particularly FabI inhibitors. The present invention also provides methods for synthesizing and administering the FabI inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Abstract: The present invention provides substituted pyridine derivatives of formula (I), which may be therapeutically useful as as anti-bacterial agents, more particularly FabI inhibitors. Formula (I) in which R1 to R5 and L have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage anti-bacterial agents, more particularly FabI inhibitors. The present invention also provides methods for synthesizing and administering the FabI inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Abstract: The present invention relates to tetrahydropyridine derivatives of formula (1) which may be therapeutically useful as anti-bacterial agents, more particularly FabI inhibitors. in which X, Y, Z and “n” have the same meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable stereoisomers thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting Enoyl-ACP reductase enzyme (FabI) activity. The present invention also provides methods for synthesizing and administering the FabI inhibitory compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitory compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Abstract: A system is provided that invokes an external web service using a composite application. The system creates a composite application definition, where the composite application definition includes external web service information and a mapping of a task operation to a service operation. The system further dynamically generates the composite application based on the composite application definition, where the composite application includes computer code. The system further deploys the composite application.

Abstract: A system is provided that orchestrate a supply chain orchestration process. The system receives a supply request and creates a supply order. The system further selects a supply chain orchestration process for the supply order, where the supply chain orchestration process includes one or more steps. The system further generates an executable supply chain orchestration process. The system further executes the executable supply chain orchestration process to generate one or more supply tasks that are defined by the one or more steps of the supply chain orchestration process. The system further sends the one or more supply tasks to one or more external supply execution systems. The system further receives one or more status values from the one or more external supply execution systems. The system further generates an overall status value for the supply chain orchestration process based on the one or more status values.

Abstract: A system for signal processing comprising a cyclic analog to digital converter structure having a first stage and a second stage, wherein the first stage is configured to receive an input signal to perform 1.5 bits/stage ADC and to generate a first stage output signal, and the second stage is configured to receive the first stage output signal and to perform fine offset tuning using a final conversion phase. The second stage further configured to perform 1.5 bits/stage ADC and to generate a second stage output that is fed back to the first stage to iteratively generate a next 1.5 bits, until (N?3) most significant bits of N bits of data are generated. A third stage configured to generate a three least significant bits of the N bits of data using a flash ADC sampling circuit that samples a residue signal at the output of the first stage.

Abstract: Provided is a fully differential adaptive bandwidth phase locked loop with differential supply regulation. One fully differential phase locked loop includes a differential active loop filter and regulator coupled to an output of a differential charge pump, a differential voltage-controlled oscillator coupled to differential control voltages developed by the differential active loop filter and regulator, and a bias circuit coupled to the differential control voltages and providing a bias current to the differential charge pump.

Abstract: A system for signal processing comprising a cyclic analog to digital converter structure having a first stage and a second stage, wherein the first stage is configured to receive an input signal to perform 1.5 bits/stage ADC and to generate a first stage output signal, and the second stage is configured to receive the first stage output signal and to perform fine offset tuning using a final conversion phase. The second stage further configured to perform 1.5 bits/stage ADC and to generate a second stage output that is fed back to the first stage to iteratively generate a next 1.5 bits, until (N?3) most significant bits of N bits of data are generated. A third stage configured to generate a three least significant bits of the N bits of data using a flash ADC sampling circuit that samples a residue signal at the output of the first stage.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: Provided is a fully differential adaptive bandwidth phase locked loop with differential supply regulation. One fully differential phase locked loop includes a differential active loop filter and regulator coupled to an output of a differential charge pump, a differential voltage-controlled oscillator coupled to differential control voltages developed by the differential active loop filter and regulator, and a bias circuit coupled to the differential control voltages and providing a bias current to the differential charge pump.