Patents by Inventor Chandravadan R. Shah

Chandravadan R. Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Patent number: 9062044
    Abstract: Certain disubstituted 3,8-diaza-bicyclo[4.2.0]octane and 3,6-diazabicyclo[3.2.0]heptane are described, which are useful as orexin inhibitors. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: June 23, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Bryan James Branstetter, Michael A. Letavic, Kiev S. Ly, Dale A. Rudolph, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman
  • DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
    Publication number: 20140179697
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Application
    Filed: December 23, 2013
    Publication date: June 26, 2014
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode Johnson, Emily M. Stocking, Devin M. Swanson
  • Fused heterocyclic compounds as orexin receptor modulators
    Patent number: 8680275
    Abstract: Disubstituted 3,8-diaza-bicyclo[4.2.0]octane and 3,6-diazabicyclo[3.2.0]heptane compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: March 25, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Bryan James Branstetter, Michael A. Letavic, Kiev S. Ly, Dale A. Rudolph, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman
  • Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Patent number: 8653263
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: February 18, 2014
    Assignee: Janssen Pharmaceutica
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode-Johnson, Emily M. Stocking, Devin M. Swanson
  • SEROTONIN RECEPTOR MODULATOR
    Publication number: 20140038943
    Abstract: Certain biphenyic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Application
    Filed: October 10, 2013
    Publication date: February 6, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Nicholas I. Carruthers, Wenying Chai, Jill A. Jablonowski, Chandravadan R. Shah, Brock T. Shireman, Devin M. Swanson, Vi Tran, Victoria Wong
  • Serotonin receptor modulators
    Patent number: 8642583
    Abstract: The biphenyic compounds of formula (I) are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: February 4, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nicholas I. Carruthers, Wenying Chai, Jill A. Jablonowski, Chandravadan R. Shah, Brock T. Shireman, Devin M. Swanson, Vi T. Tran, Victoria D. Wong
  • DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
    Publication number: 20130137672
    Abstract: Certain disubstituted 3,8-diaza-bicyclo[4.2.0]octane and 3,6-diazabicyclo[3.2.0]heptane are described, which are useful as orexin inhibitors. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Application
    Filed: October 21, 2010
    Publication date: May 30, 2013
    Inventors: Bryan James Branstetter, Michael A. Letavic, Kiev S. Ly, Dale A. Rudolph, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman
  • DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
    Publication number: 20120208812
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Application
    Filed: October 21, 2010
    Publication date: August 16, 2012
    Applicant: Janssen Pharmaceutica N.V.
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode-Johnson, Emily M. Stocking, Devin M. Swanson
  • FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS
    Publication number: 20120202783
    Abstract: Disubstituted 3,8-diaza-bicyclo[4.2.0]octane and 3,6-diazabicyclo[3.2.0]heptane compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Application
    Filed: October 21, 2010
    Publication date: August 9, 2012
    Inventors: Bryan James Branstetter, Michael A. Letavic, Kiev S. Ly, Dale A. Rudolph, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman
  • Substituted pyrrolidine amides as modulators of the histamine Hreceptor
    Patent number: 8236792
    Abstract: Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: August 7, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nicholas I Carruthers, Michael A. Letavic, Kiev S. Ly, Neelakandha S. Mani, Daniel J. Pippel, Chandravadan R. Shah, Akinola Soyode-Johnson, Emily M. Stocking, Lana Young
  • PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR
    Publication number: 20120129870
    Abstract: The present invention is directed to piperidinyl and piperazinyl derivatives of formula (II) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.
    Type: Application
    Filed: December 17, 2008
    Publication date: May 24, 2012
    Inventors: Wenying Chai, Jill A. Jablonowski, Dale A. Rudolph, Chandravadan R. Shah, Devin M. Swanson, Victoria D. Wong
  • Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor
    Patent number: 8183239
    Abstract: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: May 22, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Pascal Bonaventure, Nicholas I. Carruthers, Wenying Chai, Curt A. Dvorak, Jill A. Jablonowski, Dale A. Rudolph, Mark Seierstad, Chandravadan R. Shah, Devin M. Swanson, Victoria D. Wong
  • PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR
    Publication number: 20120015957
    Abstract: The present invention is directed to piperidinyl and piperazinyl derivatives of formula (I) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.
    Type: Application
    Filed: December 17, 2008
    Publication date: January 19, 2012
    Inventors: Wenying Chai, Curt A. Dvorak, Jill A. Jablonowski, Dale A. Rudolph, Chandravadan R. Shah, Victoria D. Wong
  • Isoxazole compounds as histamine Hmodulators
    Patent number: 7947718
    Abstract: Certain isoxazole compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: May 24, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nicholas I. Carruthers, Chandravadan R. Shah, Devin M. Swanson
  • Isoxazole Compounds as Histamine H3 modulators
    Publication number: 20100022539
    Abstract: Certain isoxazole compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
    Type: Application
    Filed: September 15, 2009
    Publication date: January 28, 2010
    Inventors: Nicholas I. Carruthers, Chandravadan R. Shah, Devin M. Swanson
  • NON-IMIDAZOLE ARYLOXYALKYLAMINES
    Publication number: 20100004241
    Abstract: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
    Type: Application
    Filed: August 14, 2009
    Publication date: January 7, 2010
    Inventors: Richard Apodaca, Nicholas I. Carruthers, Curt A. Dvorak, Dale A. Rudolph, Chandravadan R. Shah, Wei Xiao
  • SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
    Publication number: 20090291903
    Abstract: Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
    Type: Application
    Filed: May 19, 2009
    Publication date: November 26, 2009
    Inventors: Nicholas I. Carruthers, Michael A. Letavic, Kiev S. Ly, Neelakandha S. Mani, Daniel J. Pippel, Chandravadan R. Shah, Akinola Soyode-Johnson, Emily M. Stocking, Lana Young
  • OCTAHYDRO-INDOLIZINE AND QUINOLIZINE AND HEXAHYDRO-PYRROLIZINES
    Publication number: 20090263322
    Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
    Type: Application
    Filed: June 30, 2009
    Publication date: October 22, 2009
    Inventors: Richard Apodaca, Nicholas I. Carruthers, John R. Carson, Wenying Chai, Annette K. Kwok, Xiaobing Li, Timothy W. Lovenberg, Dale A. Rudolph, Chandravadan R. Shah
  • Indoles and benzoimidazoles as modulators of the histamine Hreceptor
    Patent number: 7544698
    Abstract: Benzoimidazole and indole compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: June 9, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: James P. Edwards, Brad M. Savall, Chandravadan R. Shah
  • Heterocyclic compounds
    Patent number: 7504426
    Abstract: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: March 17, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Nicholas I. Carruthers, Curt A. Dvorak, James P. Edwards, Cheryl A. Grice, Jill A. Jablonowski, Kiev S. Ly, Barbara A. Pio, Chandravadan R. Shah, Jennifer D. Venable