Patents by Inventor Chang-Chi Hsieh

Chang-Chi Hsieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL-MOLECULE PEPTIDE AND USE THEREOF AGAINST METABOLIC-ASSOCIATED FATTY LIVER DISEASE AND FOR REDUCING BODY WEIGHT
    Publication number: 20240409581
    Abstract: A novel small-molecule peptide and a use thereof against metabolic-associated fatty liver disease (MAFLD) are disclosed. The small-molecule peptide has a sequence including Tyr and Phe. The small-molecule peptide has activity in inhibiting fat build-up in the liver, regulating metabolizing enzymes in the liver, and regulating the blood glucose level. The small-molecule peptide can be used to treat or improve MAFLD and MAFLD-related diseases.
    Type: Application
    Filed: September 7, 2023
    Publication date: December 12, 2024
    Inventors: Vipul WAYAL, Chang-Chi HSIEH
  • Refined product obtained from rice hull and preparation process and use thereof
    Patent number: 10376577
    Abstract: Disclosed herein is a refined product obtained from a rice hull, which consists essentially of a type II arabinogalactan having a number average molecular weight in the range of 56 to 103 kDa. Also disclosed are a process for producing the refined product and use of the refined product for enhancing the biological activity of innate immune cells, as well as for treating allergy and cancer.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: August 13, 2019
    Assignee: China Medical University
    Inventors: Wen-Chuan Lin, Li-Chan Yang, Chang-Chi Hsieh
  • Screening method for rapid identification of hybridomas
    Patent number: 9797838
    Abstract: This present invention relates to a screening method for rapidly identifying the hybridomas upon cell size and the expression of an exogenous label such as fluorescence labeling. This method of this present invention can largely shortens the time cost for antibody development by saving the time period with comparison of traditional methods using cell culture with media such as HAT medium.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: October 24, 2017
    Assignee: TUNGHAI UNIVERSITY
    Inventors: Chang-Chi Hsieh, Ming-Shiou Jan, Ai Shih, Chuan-Kai Chou, Yen-Wan Hsiao, Ying-Chun Lai
  • Screening method for rapid identification of hybridomas
    Publication number: 20160258957
    Abstract: This present invention relates to a screening method for rapidly identifying the hybridomas upon cell size and the expression of an exogenous label such as fluorescence labeling. This method of this present invention can largely shortens the time cost for antibody development by saving the time period with comparison of traditional methods using cell culture with media such as HAT medium.
    Type: Application
    Filed: March 4, 2016
    Publication date: September 8, 2016
    Inventors: Chang-Chi HSIEH, Ming-Shiou JAN, Ai SHIH, Chuan-Kai CHOU, Yen-Wan HSIAO, Ying-Chun LAI
  • REFINED PRODUCT OBTAINED FROM RICE HULL AND PREPARATION PROCESS AND USE THEREOF
    Publication number: 20160060367
    Abstract: Disclosed herein is a refined product obtained from a rice hull, which consists essentially of a type II arabinogalactan having a number average molecular weight in the range of 56 to 103 kDa. Also disclosed are a process for producing the refined product and use of the refined product for enhancing the biological activity of innate immune cells, as well as for treating allergy and cancer.
    Type: Application
    Filed: August 20, 2015
    Publication date: March 3, 2016
    Inventors: Wen-Chuan Lin, Li-Chan Yang, Chang-Chi Hsieh
  • Aqueous extracts of spp. kinsenoside and pharmaceutical compositions useful for hepatoprotection
    Patent number: 9072770
    Abstract: A pharmaceutical composition useful for hepatoprotection is provided. The composition comprises an effective amount of kinsenoside or a pharmaceutically acceptable salt or ester thereof. An aqueous extract of Anoectochilus spp. is also provided. The extract is substantially free of ethyl acetate-philic components.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: July 7, 2015
    Assignee: CHINA MEDICAL UNIVERSITY
    Inventors: Wen-Chuan Lin, Jin-Bin Wu, Hui-Ya Ho, Wei-Lii Lin, Chang-Chi Hsieh, Hsin-Sheng Tsay
  • Method for treating obesity
    Patent number: 9034397
    Abstract: The present invention provides methods of administering a Dendrobium polyphenol in an amount effective to lower blood sugar, treat hepatic disease, obesity or diabetes. Exemplary hepatic disease includes fibrosis, fatty liver and hepatitis. Moreover, the Dendrobium polyphenol is extracted from the plants of the genus Dendrobium.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: May 19, 2015
    Assignee: Tunghai University
    Inventors: Chang-Chi Hsieh, Chin-Tung Wu, Jie-Yu Chen, Yi-Chieh Li, Hsin-Sheng Tsay
  • Method for lowering blood glucose and method for treating hepatic disease, obesity and diabetes
    Publication number: 20140288186
    Abstract: The present invention provides methods of administering a Dendrobium polyphenol in an amount effective to lower blood sugar, treat hepatic disease, obesity or diabetes. Exemplary hepatic disease includes fibrosis, fatty liver and hepatitis. Moreover, the Dendrobium polyphenol is extracted from the plants of the genus Dendrobium.
    Type: Application
    Filed: October 30, 2013
    Publication date: September 25, 2014
    Applicant: Tunghai University
    Inventors: Chang-Chi Hsieh, Chin-Tung Wu, Jie-Yu Chen, Yi-Chieh Li, Hsin-Sheng Tsay
  • Non-polysaccharide constituent of genus Dendrobium, usage for the non-polysaccharide constituent of genus Dendrobium and extracting method thereof
    Publication number: 20120315289
    Abstract: The present invention discloses a non-polysaccharide constituent for positively regulating the immune system in the therapy of allergic diseases. The non-polysaccharide constituent is extracted from genus Dendrobium by incubating in alcohol and extracting using solvents with different polarity.
    Type: Application
    Filed: October 26, 2011
    Publication date: December 13, 2012
    Inventors: Hsin-Sheng Tsay, Chang-Chi Hsieh, Chin-Tung Wu, Yu-Chang Chen, Chao-Lin Kuo, Shu-Fang Lo
  • ANOECTOCHILUS SPP. POLYSACCHARIDE EXTRACTS FOR STIMULATING GROWTH OF ADVANTAGEOUS BACTERIA, STIMULATING RELEASE OF GRANULOCYTE COLONY-STIMULATING FACTOR, MODULATING T HELPER CELL TYPE I, AND/OR MODULATING T HELPER CELL TYPE II AND USES OF THE SAME
    Publication number: 20120277182
    Abstract: An Anoectochilus spp. polysaccharide extract for stimulating the growth of advantageous bacteria, stimulating the release of granulocyte colony-stimulating factor (G-CSF), modulating T helper cell type I (Th1 cell), and/or modulating T helper cell type II (Th2 cell) is provided. The extract comprises an effective amount of a type II arabinogalactan of Anoectochilus spp. Also provided are a method for the preparation of the Anoectochilus spp. polysaccharide extract and the use of the extract.
    Type: Application
    Filed: July 11, 2012
    Publication date: November 1, 2012
    Applicant: CHINA MEDICAL UNIVERSITY
    Inventors: Wen-Chuan LIN, Chang-Chi HSIEH, Ting-Jang LU, Hsin-Sheng TSAY, Li-Chan YANG, Chia-Chieh LIN, Chung-Huang WANG
  • AQUEOUS EXTRACTS OF ANOECTOCHILUS SPP. KINSENOSIDE AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR HEPATOPROTECTION
    Publication number: 20110142966
    Abstract: A pharmaceutical composition useful for hepatoprotection is provided. The composition comprises an effective amount of kinsenoside or a pharmaceutically acceptable salt or ester thereof. An aqueous extract of Anoectochilus spp. is also provided. The extract is substantially free of ethyl acetate-philic components.
    Type: Application
    Filed: December 13, 2010
    Publication date: June 16, 2011
    Applicant: CHINA MEDICAL UNIVERSITY
    Inventors: Wen-Chuan LIN, Jin-Bin Wu, Hui-Ya Ho, Wei-Lii Lin, Chang-Chi Hsieh, Hsin-Sheng Tsay
  • Anoectochilus SPP. polysaccharide extracts for stimulating growth of advantageous bacteria, stimuating release of granulocyte colony-Stimulating factor, modulating T helper cell type I, and/or modulating T helper cell type II and uses of the same
    Publication number: 20110082103
    Abstract: An Anoectochilus spp. polysaccharide extract for stimulating the growth of advantageous bacteria, stimulating the release of granulocyte colony-stimulating factor (G-CSF), modulating T helper cell type I (Th1 cell), and/or modulating T helper cell type II (Th2 cell) is provided. The extract comprises an effective amount of a type II arabinogalactan of Anoectochilus spp. Also provided are a method for the preparation of the Anoectochilus spp. polysaccharide extract and the use of the extract.
    Type: Application
    Filed: March 1, 2010
    Publication date: April 7, 2011
    Applicant: CHINA MEDICAL UNIVERSITY
    Inventors: Wen-Chuan Lin, Chang-Chi Hsieh, Ting-Jang Lu, Hsin-Sheng Tsay, Li-Chan Yang, Chia-Chieh Lin, Chung-Huang Wang
  • Aqueous extracts of anoectochilus spp. kinsenoside-comprising pharmaceutical compositions useful for hepatoprotection and uses of the same
    Publication number: 20080241283
    Abstract: A pharmaceutical composition useful for hepatoprotection is provided. The composition comprises an effective amount of kinsenoside or a pharmaceutically acceptable salt or ester thereof. An aqueous extract of Anoectochilus spp. is also provided. The extract is substantially free of ethyl acetate-philic components.
    Type: Application
    Filed: September 13, 2007
    Publication date: October 2, 2008
    Applicant: China Medical University
    Inventors: Wen-Chuan Lin, Jin-Bin Wu, Hui-Ya Ho, Wei-Lii Lin, Chang-Chi Hsieh, Hsin-Sheng Tsay