Patents by Inventor Chang-Jing G. Yeh

Chang-Jing G. Yeh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycoform fractions of recombinant soluble complement receptor 1 (sCR1) having extended half-lives in vivo
    Patent number: 5456909
    Abstract: The present invention relates to novel glycoforms and preparations of the soluble complement receptor type 1 (sCR1), and their uses in the therapy of complement mediated diseases and disorders involving inflammation and inappropriate complement activation and in thrombotic or shock state conditions. The invention provides novel glycoforms and methods for producing, detecting, enriching and purifying such glycoforms. The invention further provides methods of specifically producing a glycoform by recombinant or chemical means. Preferred embodiments of the invention include sialylated glycoforms and glycoforms with a pI.ltoreq.5.1 determined by chromatofocusing or with a sialic acid to mannose molar ratio of >0.25. The glycoforms may be formulated alone in therapeutic compositions or in combination with thrombolytic agents.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: October 10, 1995
    Assignees: T Cell Sciences, Inc., SmithKline Beecham p.l.c.
    Inventors: Henry C. Marsh, Jr., Richard A. G. Smith, Chang-Jing G. Yeh, John Lifter, Anne M. Freeman, Michael L. Gosselin