Abstract: A method of down-mixing a multi-channel audio signal is provided. The method including restoring sub-band Pulse Coded Modulation (PCM) samples for each channel of the multi-channel audio signal by decoding the multi-channel audio-signal and then dequantizing a sub-band coded multi-channel audio signal, scaling the restored sub-band PCM samples for each channel with a coefficient corresponding to a down-mixing configuration, generating sub-band PCM samples corresponding to predetermined channels by down-mixing the scaled sub-band PCM samples for each channel into the predetermined channels, and performing inverse sub-band filtering on the generated sub-band PCM samples corresponding to the predetermined channels.

Abstract: Downmixing multi-channel audio signals to target channels by pre-downmixing frequency coefficients that are encoded using a most frequently used block type in stereo channels in the frequency domain, thereby reducing an amount of calculations and an amount of power required to downmix the multi-channel audio signals.

Abstract: The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors.

Abstract: The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors.