Abstract: A ratchet wrench with a fixing structure contains: an operating handle, a driving head, an accommodating cavity, and a first opening. A toothed block is accommodated in the accommodating cavity and has an octagonal hole. An actuating portion is accommodated in the octagonal hole and has an octagonal ball, an upper disc, a lower disc, a peripheral groove defined between the upper disc and the lower disc, and a connecting stem. The octagonal ball has at least one first aperture, a spring and a cap which are both mounted in the at least one first aperture, and the actuating portion also has a second opening, wherein the second opening has a pressing post inserted therein, and the second aperture has a steel ball fixed therein. A cover is locked on a lower end of the driving head and has a third opening defined thereon to insert the connecting stem.