Patents by Inventor Chang-Yo HSUAN

Chang-Yo HSUAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190060365
    Abstract: Disclosed is a pharmaceutical composition for treating chronic obstructive pulmonary disease, comprising an effective amount of human mesenchymal stem cells, human serum albumin, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method for treating chronic obstructive pulmonary disease in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising an effective amount of human mesenchymal stem cells, human serum albumin, and a pharmaceutically acceptable carrier or diluent.
    Type: Application
    Filed: August 25, 2017
    Publication date: February 28, 2019
    Applicant: Meridigen Biotech Co., Ltd.
    Inventors: Chang-Yo HSUAN, Willie LIN, Yu-Chin SU, Tang-bo Chung WU, Yu-Chieh Wen
  • Publication number: 20190054144
    Abstract: Disclosed is a pharmaceutical composition for treating ischemic stroke, comprising an effective amount of human mesenchymal stem cells, human serum albumin, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method for treating ischemic stroke in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising an effective amount of human mesenchymal stem cells, human serum albumin, and a pharmaceutically acceptable carrier or diluent. In addition, a method for promoting secretion of hepatocyte growth factor by human mesenchymal stem cells is disclosed.
    Type: Application
    Filed: August 15, 2017
    Publication date: February 21, 2019
    Applicant: Meridigen Biotech Co., Ltd.
    Inventors: Chang-Yo HSUAN, Willie LIN, Yu-Chin SU, Tang-bo Chung WU
  • Publication number: 20180340224
    Abstract: Disclosed is a method for identifying a greater risk for developing bronchopulmonary dysplasia (BPD) of a preterm infant. The method comprises obtaining a genomic DNA sample from the preterm infant's mother, genotyping rs2280789 SNP in the RANTES gene, and determining the preterm infant as being at risk of developing BPD if the genotype of the rs2280789 SNP is CC. Also disclosed are a primer pair for genotyping rs2280789 SNP in the RANTES gene, and a method thereof.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 29, 2018
    Applicant: Meribank Biotech Co., Ltd.
    Inventors: Chang-Yo HSUAN, Willie LIN, Wei-Ting LIU, Meng-Hua LEE, Ting-Ting TSENG
  • Publication number: 20180340223
    Abstract: Disclosed is a method for identifying a greater risk for developing bronchopulmonary dysplasia (BPD) of a preterm infant. The method comprises obtaining a genomic DNA sample from the preterm infant's mother, genotyping rs1800566 SNP in the NQO1 gene, and determining the preterm infant as being at risk of developing BPD if the genotype of the rs1800566 SNP is TT. Also disclosed are a primer pair for genotyping rs1800566 SNP in the NQO1 gene, and a method thereof.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 29, 2018
    Applicant: Meribank Biotech Co., Ltd.
    Inventors: Chang-Yo Hsuan, Willie Lin, Wei-Ting Liu, Meng-Hua Lee, Ting-Ting Tseng
  • Publication number: 20180327842
    Abstract: Disclosed is a method of identifying a greater risk for developing bronchopulmonary dysplasia (BPD) in a preterm infant. The method comprises obtaining a genomic DNA sample from the preterm infant's mother, identifying the nucleotide of rs2280789 SNP in the RANTES gene and the nucleotide of rs1800566 SNP in the NQO1 gene, and determining the preterm infant as being at risk of developing BPD when the genotype of rs2280789 SNP carries C nucleotide and the genotype of rs1800566 SNP carries T nucleotide.
    Type: Application
    Filed: May 11, 2017
    Publication date: November 15, 2018
    Applicant: Meribank Biotech Co., Ltd.
    Inventors: Chang-Yo HSUAN, Willie LIN, Wei-Ting LIU, Meng-Hua LEE, Ting-Ting TSENG
  • Publication number: 20180171403
    Abstract: Provided is a method for determining the risk of preterm labor in a pregnant female subject. The method comprises detecting the expression level of one or more markers selected from the group consisting of TMEM200A, TMEM108 and GXYLT2, in a sample derived from the pregnant female subject.
    Type: Application
    Filed: December 5, 2017
    Publication date: June 21, 2018
    Applicant: Meribank Biotech Co., Ltd
    Inventors: Chang-Yo HSUAN, Willie LIN, Wei-Ting LIU
  • Publication number: 20180148787
    Abstract: Provided is a method for determining the risk of bronchopulmonary dysplasia (BPD) of a preterm infant. The method comprises detecting the expression level of EPHB2 in a primary culture of mesenchymal stem or stromal cells (MSCs) derived from a placenta-related tissue of the infant's mother or umbilical cord blood of the infant.
    Type: Application
    Filed: October 19, 2017
    Publication date: May 31, 2018
    Applicant: Meribank Biotech Co., Ltd.
    Inventors: Chang-Yo Hsuan, Willie Lin, Wei-Ting Liu
  • Publication number: 20180059109
    Abstract: A method of distinguishing mesenchymal stem cells (MSCs) from fibroblasts is provided. Also provided is a method of increasing a purity of mesenchymal stem cells (MSCs) population in a cell culture. The above-mentioned methods each comprise a step of sorting or isolating the cells by a marker of CD146 from a cell culture derived from a placenta-related tissue. Further provided is a method of assessing purity of mesenchymal stem cells (MSCs) in a cell culture derived from a placenta-related tissue, comprising determining the percentage of cells expressing CD146 in the culture.
    Type: Application
    Filed: December 7, 2016
    Publication date: March 1, 2018
    Applicant: Meridigen Biotech Co., Ltd.
    Inventors: Chang-Yo HSUAN, Willie LIN, Yu-Chin SU, Wei-Ting LIU, Meng-Wei LI, Mao-Kuang DU
  • Patent number: 9470685
    Abstract: A method of distinguishing mesenchymal stem cells (MSCs) in a primary culture of cells derived from a placenta-related tissue is provided. Also provided is a method of increasing the purity of MSC population in a primary culture of cells derived from a placenta-related tissue. Further provided is a method of isolating a MSC population which is more responsive in an inflammatory environment. Said methods each comprise a step of sorting the cells by a marker of EphA2.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: October 18, 2016
    Assignee: MERIDIGEN BIOTECH CO., LTD.
    Inventors: Chang-Yo Hsuan, Wei-Ting Liu, Shih-Pei Shen, Yun Lin, Yuan-Tsung Li, Chia-Chi Chang
  • Publication number: 20160161483
    Abstract: A method of distinguishing mesenchymal stem cells (MSCs) in a primary culture of cells derived from a placenta-related tissue is provided. Also provided is a method of increasing the purity of MSC population in a primary culture of cells derived from a placenta-related tissue. Further provided is a method of isolating a MSC population which is more responsive in an inflammatory environment. Said methods each comprise a step of sorting the cells by a marker of EphA2.
    Type: Application
    Filed: December 5, 2014
    Publication date: June 9, 2016
    Applicant: MERIDIGEN BIOTECH CO., LTD.
    Inventors: Chang-Yo HSUAN, Wei-Ting LIU, Shih-Pei SHEN, Yun LIN, Yuan-Tsung LI, Chia-Chi CHANG
  • Publication number: 20160116766
    Abstract: Disclosure is a detachable image input/output device which is applicable to detachably connect to one of temples of a glasses frame, and comprises an L-shaped body, an image capture module and an image display module. A side of the L-shaped body has a connecting part, and the side of the L-shaped body corresponds to the temple, the L-shaped body connects to the temple by the connection part, an end of the L-shaped body has a bending part, and the bending part of the L-shaped body being bent to a direction perpendicular to the temple. The image capture module is disposed at the bending part of the L-shaped body and adjacent to the bending position of the L-shaped body. The image display module is disposed at the bending part of the L-shaped body and far away the bending position of the L-shaped body.
    Type: Application
    Filed: October 23, 2014
    Publication date: April 28, 2016
    Inventors: CHANG-YO HSUAN, HSIN-KUO HO
  • Publication number: 20160113574
    Abstract: Provided discloses an electronic device for calculating physical energy consumption including a gravity sensing module, a storage module, a processing module, and a touch control display module. The gravity sensing module detects at least one movement of the electronic device for calculating physical energy consumption to generate at least one movement signal. The storage module stores a plural physical training mode and a plural predetermined exercise value. The processing module connects to the gravity sensing module and the storage module, the processing module receives at least one movement signal and generates at least one active value depending on the movement signal, and subtracts at least one active value from the predetermined exercise value corresponding to one of the physical training modes to generate at least one exercising consumption signal. The touch control display module connects to the processing module, and receives and displays at least one exercising consumption signal.
    Type: Application
    Filed: October 23, 2014
    Publication date: April 28, 2016
    Inventors: Chang-Yo HSUAN, Hsin-Kuo HO
  • Publication number: 20160117055
    Abstract: Disclosure is a flexible image input/output device comprising a first body, a second body and a flexible member. The first body has an image capture module generating a first image signal. The second body separates from the first body and has an image display module receiving the first image signal and displaying a first image. The flexible member, of which one end connects to the first body and another end connects to the second body to transmit the first image signal from the image capture module to the image display module.
    Type: Application
    Filed: October 23, 2014
    Publication date: April 28, 2016
    Inventors: CHANG-YO HSUAN, HSIN-KUO HO