Abstract: The present invention of “A production method for high-activity superoxide dismutase (SOD) and application in methods of both the solid-state and liquid-state fermentation” lies in processing the strains of Bacillus subtilis with quantifying the activity of superoxide dismutase (SOD) in fermentation broth by nitro blue tetrazolium (NBT) reduction method, and then one kind of high-activity SOD-producing strain, which will be acquired while after the dialysis process, named Strain S-8 and afterward, this strain S-8 will be utilized to produce SOD by performing the liquid-state and solid-state fermentation methods respectively.