Abstract: The invention provides a class of photochromic polydiorganosiloxane vinylic crosslinkers. Each of the photochromic polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and photochromic siloxane unit having one methyl substituent and one organic substituent having a photochromic moiety that capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light; (2) two terminal ethylenically-unsaturated groups. The invention also provides a soft photochromic contact lens, especially a photochromic silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers.

Abstract: Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T10h?) of from about 50° C. to about 90° C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T10h??20)° C. to about T10h?° C. for a first curing time and maintaining a second curing temperature of from about (T10h?+10)° C. to about (T10h?+35)° C. for a second curing time.

Abstract: An end cover assembly, an air cylinder, a tread sweeper and a railway vehicle.

Abstract: The present invention provides an antibody binding a human tumor-associated calcium signal sensor 2 (Trop-2) protein or fragments thereof, and use of the antibody or fragments thereof in preventing or treating diseases. The antibody or fragments thereof of the present invention can effectively bind to the human Trop-2 protein, and have internalization activity, and the internalization activity is enhanced after ADC drug labeling, and the in vivo efficacy and safety of a mouse model are not lower than those of a control antibody.

Abstract: A touch substrate, a display panel, and an electronic device are provided. The touch substrate includes a base substrate, and first touch electrodes and second touch electrodes on the base substrate; the first touch electrodes are arranged in a first direction, with each first touch electrode extending in a second direction; the second touch electrodes are arranged in the second direction, with each second touch electrode extending in the first direction, the first touch electrode and the second touch electrode are spaced apart and insulated from each other; in a direction perpendicular to the base substrate, the first touch electrodes overlap with the second touch electrodes to form overlapping regions; and in the overlapping region, any first edge extending in the first direction in the conductive grid of the firm touch electrode does not overlap with the first edge in the conductive grid of the second touch electrode.

Abstract: A method of sampling an ejection of a sample from a liquid container includes disposing the liquid container adjacent an open port in-terface. The container includes a sampling port. The open port interface en-gages with the sampling port. The sample from the liquid container is eject-ed, through the sampling port, and into the open port interface. The sample is analyzed with a mass spectrometry device.

Abstract: The invention provides a method for imaging and thickness determination of coatings on coated contact lenses. The method comprises selectively staining a negatively-charged-groups-containing coating over the lens body of a coated contact lens by immersing the coated contact lens in an aqueous solution comprising a fluorescently-labeled polycationic polymer and having a pH of from about 6.5 to 8.0; orthogonally cutting the selectively-stained coated contact lens; and determining the thickness of the coating on the coated contact lens. In addition, the invention provides a method for selecting a candidate coating material comprising negatively charged groups for applying a coating with a desired thickness onto silicone hydrogel contact lenses and for optimizing a coating process for producing coated silicone hydrogel contact lenses with a desired thickness coating thereon.

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

Abstract: Methods and systems for training a language model include retrieving a knowledge sentence, related to an input sentence, from a knowledge base. The input sentence, the knowledge sentence, and a prompt are encoded into an intermediate representation. The intermediate representation is decoded to generate a named entity from the input sentence that is of a type specified by the prompt. A language model is fine-tuned based on the named entity.

Abstract: The invention relates to the technical field of synthesis of a heterocyclic compound, and particularly discloses a method for preparing 2,4-diaminopyrimidine oxide. The method includes the steps of: cyclizing 3-oxopropionitrile with guanidine under an oxidizing condition to obtain 2,4-diaminopyrimidine oxide, wherein the 3-oxopropionitrile is obtained by oxidizing 3-hydroxypropionitrile, which is a cheap and easily available pharmaceutical chemical, as a raw material. The method of the present invention is green and mild, realizing the synthesis of Aminexil from a simple, cheap and easily available raw material.

Abstract: A display panel, comprising a first insulating structural layer, a first crack detection line, a second insulating structural layer and a second crack detection line which are sequentially arranged on a substrate, wherein the first crack detection line and the second crack detection line are both located in a peripheral area and are arranged around a display area, one end of the first crack detection line is configured to receive a detection signal, and the other end of the first crack detection line is configured to output a first output signal, and one end of the second crack detection line is configured to receive a detection signal and the other end of the second crack detection line is configured to output a second output signal.

Abstract: Embodiments of this application provide a resource preemption method, an apparatus, and a system, to reduce a quantity of times of frequent resource preemption, and improve resource security. In one example, a first terminal device obtains a first time interval and a second time interval, and preempts or determines not to preempt a first resource according to a first preset rule. The first resource is a resource reserved by a second terminal device or a resource reserved for a first service to be transmitted by the first terminal device. The first time interval is a time interval related to the first resource. The second time interval is used to indicate a preemption forbidden time. The first preset rule is determined based on the first time interval and the second time interval.

Abstract: Disclosed are a method and a system for forecasting an agricultural product price based on signal decomposition and deep learning. The method includes: S1, obtaining price subsequences by performing a complementary ensemble empirical mode decomposition (CEEMD) on an original price sequence of agricultural products; S2, obtaining a reconstructed sequence based on the price subsequences; S3, obtaining data features of the reconstructed sequence based on the reconstructed sequence; and S4, constructing a Bi-directional Sequence to Sequence (BiSeq2seq) model, and inputting the data features of the reconstructed sequence into a CCS-Bi-directional Sequence to Sequence (CCS-BiSeq2seq) model to obtain a forecasting result.

Abstract: A lipid delivery system, a virus-like structure (VLS) vaccine constructed therefrom, and a lipid particle capable of encapsulating an mRNA molecule encoding a SARS-CoV-2-specific antigen are provided. After the lipid particle encapsulates an mRNA molecule encoding a SARS-CoV-2 antigen, a SARS-CoV-2 S1 antigen protein can be embedded on a surface of an envelope structure of the lipid under specific buffer conditions to produce a VLS vaccine with an antigen-encoding mRNA molecule encapsulated inside and an outer membrane presenting a required viral antigen protein. The vaccine has a superior specific antibody-inducing ability to a SARS-CoV-2 mRNA vaccine and a polypeptide vaccine, can maintain a long-lasting high antibody level, and can also exhibit excellent immune binding abilities for the emerging different variants.

Abstract: A method for preparing a COF-protected electrode and an electrode are provided. The method includes mixing an organic framework, a small molecular organic acid and a solvent, adding a polar aqueous solution containing a substrate thereto, mixing the above uniformly and heating the system at a low temperature under an inert atmosphere, filtering the solution to obtain precipitates, washing and drying the precipitates to obtain a COF film grown on a surface of the substrate; coating a protective layer on the COF film to obtain a substrate/COF/protective layer film; etching off the substrate to obtain a COF/protective layer film; and transferring the COF/protective layer film to a surface of the electrode, and removing the protective layer.

Abstract: Provided is an array substrate. The array substrate includes: a base substrate, and a plurality of gate lines, a plurality of data lines, a plurality of sub-pixels and a plurality of touch signal lines disposed on the base substrate. The data lines have a plurality of first extending parts and a plurality of second extending parts which are in an alternating arrangement. When the array substrate is used to prepare a liquid crystal display panel and the liquid crystal display panel is displaying, in each column of the sub-pixels, the voltage polarities of the two adjacent sub-pixels which respectively belong to two adjacent first pixel regions are opposite.

Abstract: A keycap assembly can include a keycap that includes a chargeable light emissive material. The keycap assembly can include a light sensor configured to sense light emitted by or incident to the chargeable light emissive material. The keycap assembly can further include a microcontroller. In certain implementations, the microcontroller includes a processor and a memory device storing instructions that, when executed by the processor, cause the microcontroller to: receive an electrical signal from the light sensor; and determine a property of the chargeable light emissive material based on the electrical signal, where the property includes at least one of a charge level or an illumination intensity.

Abstract: Provided are an antibody and a preparation method therefor. The antibody is, such as a humanized anti-human CD47 monoclonal antibody or fragment thereof, and a bispecific antibody targeting PD-L1 and CD47 or an antigen-binding fragment thereof. The bispecific antibody comprises two heavy chains and two light chains, variable regions of the two heavy chains are heterologous, and variable regions of the two light chains have similar sequences. The provided bispecific antibody has the light chains having the similar sequences, thus solving the technical problem of light and heavy chain mismatch during an assembly process of bispecific antibodies.

Abstract: A display panel and a manufacturing method thereof, and a display device are provided. The display panel includes: a substrate; a plurality of light-emitting elements and an encapsulation layer disposed on the substrate, with the plurality of light-emitting elements located between the encapsulation layer and the substrate; a transfer layer disposed on a side of the encapsulation layer away from the substrate and bonded to the encapsulation layer, with an adhesive force between the transfer layer and the encapsulation layer greater than that between an organic adhesive layer and the encapsulation layer, and the organic adhesive layer configured to react chemically under a preset catalytic condition to be formed to the transfer layer; and a touch structure (40) disposed on a side of the transfer layer away from the substrate and configured to detect occurrence of a touch action.

Abstract: In view of the technical problem that TGF-? RH and a fusion protein thereof are prone to degradation and breakage during the process of recombinant expression, provided are a TGF-? RII mutant and a fusion protein thereof. Compared with the extracellular region of the wild-type TGF-? RII of SEQ ID NO: 6, the TGF-? RII mutant has a mutation selected from Gln at position 6, Asp at position 12 and Gly at position 20. The TGF-? RII mutant is capable of binding to TGF-?. Compared to wild-type TGF-? RII, the TGF-? RII mutant has less breakage and/or degradation during recombination expression. It is convenient for large-scale production of antibodies/the TGF-? RII bifunctional protein with a more stable quality.