Patents by Inventor Changbin Guo

Changbin Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrug compound of levosimendan, preparation method and use thereof
    Patent number: 11591299
    Abstract: The invention relates to a prodrug compound of levosimendan as shown by the formula below, and solvates, hydrates, N-oxides, stereoisomers, and pharmaceutically acceptable salts thereof, wherein each of Ra and Rb is selected from hydrogen or C1-C6 alkyl; Rp is selected from a basic group containing N atom or an acidic group containing carboxyl group, phosphate group, sulfate group, and sulfonate group. The prodrug compound overcomes the defects of levosimendan such as poor water solubility, and has an ideal pharmacokinetic profile and excellent prospects for medicament development.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: February 28, 2023
    Assignee: Beijing Chenguang Tongchuang Pharmaceutical Research Institute Co., Ltd.
    Inventors: Shaolin Huang, Changbin Guo, Wei Li, Liang Ma, Qingjuan Yang, Pengfei Song, Jingwang Fan, Xiaosong Mao
  • Trisubstituted thiazole compounds, preparations methods, pharmaceutical compositions and medicals uses thereof
    Patent number: 8053581
    Abstract: The present invention relates to 2,4,5-trisubstituted thiazole compounds of formula (I) or all possible isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof for the inhibition of plasma PLTP activity and/or plasma CETP activity, wherein the substituents are as defined in the specification; a process for the preparation of the compounds of formula (I); a pharmaceutical composition comprising the compound of formula (I) and its use for the preparation of a medicament for treatment and/or prevention of diseases associated with the increased plasma PLTP activity and/or the increased plasma CETP activity in a mammal, such as atherosclerosis, cardiovascular diseases and peripheral vascular diseases, etc.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: November 8, 2011
    Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.C. China
    Inventors: Song Li, Changbin Guo, Xiancheng Jiang, Junhai Xiao, Zhong Wu
  • TRISUBSTITUTED THIAZOLE COMPOUNDS, PREPARATIONS METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICALS USES THEREOF
    Publication number: 20090298832
    Abstract: The present invention relates to 2,4,5-trisubstituted thiazole compounds of formula (I) or all possible isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof for the inhibition of plasma PLTP activity and/or plasma CETP activity, wherein the substituents are as defined in the specification; a process for the preparation of the compounds of formula (I); a pharmaceutical composition comprising the compound of formula (I) and its use for the preparation of a medicament for treatment and/or prevention of diseases associated with the increased plasma PLTP activity and/or the increased plasma CETP activity in a mammal, such as atherosclerosis, cardiovascular diseases and peripheral vascular diseases, etc.
    Type: Application
    Filed: August 15, 2006
    Publication date: December 3, 2009
    Inventors: Song Li, Changbin Guo, Xiancheng Jiang, Junhai Xiao, Zhong Wu