Patents by Inventor Changgong Zhang

Changgong Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8287889
    Abstract: The invention discloses a freeze-dried nanometer powder injection of ursolic acid and a preparing method thereof. It major composes of active material of ursolic acid, complex vehicle of nanometer powder, excipient of freeze-drying. Compared to other popular preparations, its advantages are high target application of liver, concentrate on the affects, increase curative effect, decrease side effect, high dispersity and stability. It is prepared through dissolving ursolic acid as active raw material in medical organic solvent, adding complex vehicle of bean lecithin and stearic acid, stirring while heating until reaction completed, adding distilled water, adding excipient, stirring while heating until reaction completed, filtering with microporous membrane and freeze-drying the filtrate. Its average particle size is 209.5 mm, drug loading is 25.2%. it is for inhibiting and treating liver cancer, decreasing expression of p53, bcl-2 and topo-II.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: October 16, 2012
    Assignee: Wuhan Liyuanheng Pharmaceutical Technology Ltd.
    Inventors: Jun Ming Xie, Yan Bai, YiMu Yi, Guang Yang, ChangGong Zhang
  • Publication number: 20060034933
    Abstract: The invention discloses a freeze-dried nanometer powder injection of ursolic acid and a preparing method thereof. It major composes of active material of ursolic acid, complex vehicle of nanometer powder, excipient of freeze-drying. Compared to other popular preparations, its advantages are high target application of liver, concentrate on the affects, increase curative effect, decrease side effect, high dispersity and stability. It is prepared through dissolving ursolic acid as active raw material in medical organic solvent, adding complex vehicle of bean lecithin and stearic acid, stirring while heating until reaction completed, adding distilled water, adding excipient, stirring while heating until reaction completed, filtering with microporous membrane and freeze-drying the filtrate. Its average particle size is 209.5 mm, drug loading is 25.2%. it is for inhibiting and treating liver cancer, decreasing expression of p53, bcl-2 and topo-II.
    Type: Application
    Filed: November 17, 2003
    Publication date: February 16, 2006
    Inventors: Jun Xie, Yan Bai, YiMu Yi, Guang Yang, ChangGong Zhang
  • Patent number: 4908490
    Abstract: This invention is related to the process and apparatus for applying stressed skin sheet coverings to large passenger vehicles. The apparatus for the process, provided by this invention includes a single phase transformer, conductors, electric contactors and a guiding apparatus. The present invention uses a specialized transformer, capable of producing a strong electric current of low voltage as an energy source, utilizing the steel skin sheet as a resistor element in the output circuit, welding the steel sheet onto the frame while the steel sheet is heated by the electric current passing through the sheet, thereby elongating the sheet at a set value due to the rise in temperature, cutting off the electricity and welding the upper and lower sides quickly onto the frame, thus finishing the process of skin covering and resulting in residual stresses within the steel skin sheet.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: March 13, 1990
    Assignee: Jilin University of Technology
    Inventors: Xicheng Jiang, Changgong Zhang, Yizhi Gao, Shiqiao Deng