Patents by Inventor Changhao Bi

Changhao Bi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR NARROWING EDITING WINDOW OF BASE EDITOR, BASE EDITOR, AND USE
    Publication number: 20240408232
    Abstract: Provided are a gRNA mutant and the use thereof, and further provided are a method for constructing same and a base editor containing same. The gRNA mutant is used in the base editor, and can universally reduce a base editing window, thereby improving the specificity of gene editing, and achieving specific editing on one base.
    Type: Application
    Filed: July 26, 2022
    Publication date: December 12, 2024
    Inventors: Xueli Zhang, Changhao Bi, Dongdong Zhao, Guo Jiang, Xuxu Chen
  • BASE EDITING SYSTEMS FOR ACHIEVING C TO A AND C TO G BASE MUTATION AND APPLICATION THEREOF
    Publication number: 20220380749
    Abstract: The present invention discloses base editing systems for mutating a base C to A and a base C to G and applications thereof. The base editing system for mutating C to A disclosed in the present invention includes cytosine deaminase AID and nCas9 nuclease or includes cytosine deaminase AID, nCas9 nuclease and uracil DNA glycosidase; the base editing system for mutating C to G of the present invention includes cytosine deaminase APOBEC, nCas9 nuclease and uracil DNA glycosidase. The experiments show that a combination of the three base editing systems for mutating C to A, C to T and A to G can realize a mutation of A, T, C or G to any base in both prokaryotes and eukaryotes.
    Type: Application
    Filed: August 19, 2020
    Publication date: December 1, 2022
    Inventors: Xueli ZHANG, Changhao BI, Dongdong ZHAO, Siwei LI
  • ENGINEERING COMPLEX MICROBIAL PHENOTYPES WITH SUCCESSIVE INTEGRATIONS OF EXOGENOUS DNA (SIEDNA)
    Publication number: 20110300553
    Abstract: The present invention relates to a recombinant E. coli exhibiting a complex phenotype, comprising three or more heterologous DNA fragments integrated into a chromosome of the recombinant E. coli bacterium. Also provided are methods for screening such a recombinant E. coli.
    Type: Application
    Filed: June 2, 2011
    Publication date: December 8, 2011
    Applicant: UNIVERSITY OF DELAWARE
    Inventors: Eleftherios T. Papoutsakis, Changhao Bi, Sergios Nicolaou