Abstract: The present application discloses a vacuum sucker with one-cavity and multi-holes, which comprises a housing, a sucker member, a suction chamber and a piston member. The housing is connected to the sucker member. The sucker member is provided with at least two recess type chambers on bottom surface. The suction chamber is provided with air holes which are communicated with the recess type chambers. The piston member is movably mounted in the suction chamber and is provided with a component for one-way communication by sucking the air from the suction chamber to the outside through a reciprocating motion of the piston member. Each of the recess type chambers is provided with an air hole communicated with the suction chamber. The present application provides a vacuum sucker with one-cavity and multi-holes, achieving a better use effect through a plurality of the recess type chambers being sucked on the sucking surface.