Patents by Inventor Changjiang Xu

Changjiang Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITION FOR SIMULTANEOUSLY MODIFYING AMINO ACIDS OF SITE 736 AND SITE 738 OF PAPN GENE AND APPLICATION THEREOF
    Publication number: 20230062272
    Abstract: Provided are compositions for simultaneously modifying amino acids of site 736 and site 738 of pAPN gene and application thereof. An sgRNA set specifically recognizing porcine pAPN gene can recognize sequences near amino acids of site 736 and site 738 of pAPN gene, and has strong specificity. On this basis, in combination with a composition consisting of a cleavage protein and a double-stranded donor sequence, simultaneous modification of amino acids of site 736 and site 738 of the pAPN gene can be realized. Under editing of the composition, the amino acids of site 736 and site 738 of the pAPN gene are modified precisely and effectively, which can prevent normal expression of other amino acids of the pAPN gene from being damaged or changed. Therefore, it can resist TGEV infection, and also can retain the physiological activity function of the pAPN protein to the maximum extent.
    Type: Application
    Filed: August 26, 2022
    Publication date: March 2, 2023
    Inventors: Kui Li, Yulian Mu, Changjiang Xu, Zhiguo Liu
  • Anti-fatigue composition, formulation and use thereof
    Patent number: 9603866
    Abstract: An anti-fatigue composition consisting of 20(S)-protopanoxadiol and lycium barbarum polysaccharide. Experiments prove that the composition exhibits a significant anti-fatigue effect. In comparison with the effect attained by the single use of lycium barbarum polysaccharide or 20(S)-protopanoxadiol, the combined use of 20(S)-protopanoxadiol and lycium barbarum polysaccharide exerts an obvious synergistic effect.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: March 28, 2017
    Assignee: Shang Hai Innovative Research Center of Traditional Chinese Medicine
    Inventors: Changjiang Xu, Weiguo Jia, Chunying Yu, Wenjing Zhang, Qiyuan Han, Qiang Ge, Qinlin Wang, Zirong Yang
  • Protopanoxadiol derivative, preparation method thereof and application thereof
    Patent number: 9475836
    Abstract: The present invention provides a protopanoxadiol derivative of structural formula I or II, a preparation method and an application thereof. The present invention performs structural modification on protopanoxadiol, and obtains multiple novel compounds with unique structures.
    Type: Grant
    Filed: January 26, 2014
    Date of Patent: October 25, 2016
    Assignee: Shang Hai Innovative Research Center of Traditional Chinese Medicine
    Inventors: Jihua Wang, Shoufu Lu, Changjiang Xu, Zirong Yang
  • Protopanoxadiol derivative, preparation method thereof and application thereof
    Publication number: 20150368289
    Abstract: The present invention provides a protopanoxadiol derivative of structural formula I or II, a preparation method and an application thereof. The present invention performs structural modification on protopanoxadiol, and obtains multiple novel compounds with unique structures.
    Type: Application
    Filed: January 26, 2014
    Publication date: December 24, 2015
    Inventors: Jihua WANG, Shoufu LU, Changjiang XU, Zirong YANG
  • ANTI-FATIGUE COMPOSITION, FORMULATION AND USE THEREOF
    Publication number: 20150065452
    Abstract: An anti-fatigue composition consisting of 20(S)-protopanoxadiol and lycium barbarum polysaccharide. Experiments prove that the composition exhibits a significant anti-fatigue effect. In comparison with the effect attained by the single use of lycium barbarum polysaccharide or 20(S)-protopanoxadiol, the combined use of 20(S)-protopanoxadiol and lycium barbarum polysaccharide exerts an obvious synergistic effect.
    Type: Application
    Filed: November 6, 2014
    Publication date: March 5, 2015
    Applicant: Shang Hai Innovative Research Center of Traditional Chinese Medicine
    Inventors: Changjiang XU, Weiguo JIA, Chunying YU, Wenjing ZHANG, Qiyuan HAN, Qiang GE, Qinlin WANG, Zirong YANG
  • ANTI-FATIGUE COMPOSITION, FORMULATION AND USE THEREOF
    Publication number: 20130123212
    Abstract: An anti-fatigue composition consisting of 20(S)-protopanoxadiol and lycium barbarum polysaccharide. Experiments prove that the composition exhibits a significant anti-fatigue effect. In comparison with the effect attained by the single use of lycium barbarum polysaccharide or 20(S)-protopanoxadiol, the combined use of 20(S)-protopanoxadiol and lycium barbarum polysaccharide exerts an obvious a clear synergistic effect.
    Type: Application
    Filed: July 27, 2011
    Publication date: May 16, 2013
    Inventors: Changjiang Xu, Weiguo Jia, Chunying Yu, Wenjing Zhang, Qiyuan Han, Qiang Ge, Qinlin Wang, Zirong Yang