Patents by Inventor Changjun FAN

Changjun FAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dexrazoxane analytical method
    Patent number: 11187683
    Abstract: A high performance liquid chromatography method used for dexrazoxane-related substances is provided, and in the method, a low-density bonding reversed-phase C18 chromatographic column resistant to pure water is employed; a gradient elution is carried out with mobile phase A and mobile phase B as eluents, the mobile phase A being a buffer, and the mobile phase B being an organic solvent; the volume percent of mobile phase A in eluents in a first stage of the gradient elution is not lower than 90%, and the duration of the first stage of the gradient elution ranges from 15˜30 minutes. By means of the analytical method, dexrazoxane is effectively separated from main impurities, and the qualities of the active pharmaceutical ingredients of dexrazoxane and the preparations thereof could be better controlled.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: November 30, 2021
    Assignee: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD.
    Inventors: Xiangfeng Chen, Hongyu Chen, Shuaihua Tian, Min Sun, Changjun Fan
  • DEXRAZOXANE ANALYTICAL METHOD
    Publication number: 20200003737
    Abstract: A high performance liquid chromatography method used for dexrazoxane-related substances is provided, and in the method, a low-density bonding reversed-phase C18 chromatographic column resistant to pure water is employed; a gradient elution is carried out with mobile phase A and mobile phase B as eluents, the mobile phase A being a buffer, and the mobile phase B being an organic solvent; the volume percent of mobile phase A in eluents in a first stage of the gradient elution is not lower than 90%, and the duration of the first stage of the gradient elution ranges from 15˜30 minutes. By means of the analytical method, dexrazoxane is effectively separated from main impurities, and the qualities of the active pharmaceutical ingredients of dexrazoxane and the preparations thereof could be better controlled.
    Type: Application
    Filed: November 30, 2017
    Publication date: January 2, 2020
    Applicant: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD.
    Inventors: Xiangfeng CHEN, Hongyu CHEN, Shuaihua TIAN, Min SUN, Changjun FAN