Patents by Inventor Changlin Chen

Changlin Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11945065
    Abstract: A multi-axis turntable includes a base, a rocker arm and a first driving device capable of driving the rocker arm to rock around the first rotation axis on the base. A swing arm and a second driving device, which is capable of driving the swing arm to swing around the second rotation axis on the rocker arm, are provided on the rocker arm. A workbench and a third driving device for driving the workbench to rotate around the third rotation axis are provided on the swing arm. The second rotation axis and the third rotation axis are parallel to each other or on different planes. Compared with the existing double rotating shaft turntable, the multi-axis turntable of the present invention has a cutting tool system of good and stable rigidity.
    Type: Grant
    Filed: November 27, 2020
    Date of Patent: April 2, 2024
    Assignee: KEDE NUMERICAL CONTROL CO., LTD.
    Inventors: Hu Chen, Xin Deng, Zhihong Wei, Hongwei Sun, Yapeng Li, Haibo Zhang, Changlin Du, Cuijuan Guo, Guoshuai Zhang, Jun Wang, Feng Wang, Yinghua Li, Shaoyi Liu, Zidan Ju
  • Publication number: 20240082229
    Abstract: The present disclosure provides methods, drug combinations and kits for treating, ameliorating, reversing and/or preventing a Helicobacter pylori (H. pylori) infection in a patient in need thereof.
    Type: Application
    Filed: August 1, 2023
    Publication date: March 14, 2024
    Applicant: TENNOR THERAPEUTICS (SUZHOU) LIMITED
    Inventors: Zhenkun MA, Guozhu GENG, Jing CHEN, Yu LIU, Xiangyi XU, Changlin AI, Junlei ZHANG, Ting SONG, Shuangshuang ZHAO
  • Patent number: 11685601
    Abstract: An express delivery conveying device is controlled by a controller and moves back and forth between a storage and pickup port and storage units to realize warehousing-in and warehousing-out operations of express deliveries. A plurality of temporary storage units are provided on the storage racks. Temporary storage cabinet doors corresponding to the temporary storage units one to one are provided on the case. The temporary storage cabinet doors are electrically connected with the controller and are capable of being opened or closed under the control of the controller for temporary storage or pickup of express deliveries. The express delivery conveying device is capable of conveying express deliveries in the temporary storage units to the storage units or conveying express deliveries in the storage units to the temporary storage units under the control of the controller.
    Type: Grant
    Filed: September 29, 2019
    Date of Patent: June 27, 2023
    Assignee: HANGZHOU DONGCHENG ELECTRONIC CO., LTD.
    Inventors: Changlin Chen, Zhonghua Chai, Lei Shen
  • Patent number: 11268110
    Abstract: This document describes biochemical pathways for producing pimeloyl-CoA using a polypeptide having the enzymatic activity of a hydroperoxide lyase to form non-3-enal and 9-oxononanoate from 9-hydroxyperoxyoctadec-10,12-dienoate. Non-3-enal and 9-oxononanoate can be enzymatically converted to pimeloyl-CoA or a salt thereof using one or more polypeptides having the activity of a dehydrogenase, a CoA ligase, an isomerase, a reductase, a thioesterase, a monooxygenase, a hydratase, and/or a thiolase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, or 1,7-heptanediol, or corresponding salts thereof. This document also describes recombinant microorganisms producing pimeloyl-CoA, as well as pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, and 1,7-heptanediol, or corresponding salts thereof.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: March 8, 2022
    Assignee: INV Nylon Chemicals Americas, LLC
    Inventors: Alex Van Eck Conradie, Adriana L. Botes, Alexander Brett Foster, Changlin Chen
  • Publication number: 20210094760
    Abstract: The present invention discloses a storage and pickup apparatus with batch express delivery storage and reserved express delivery pickup functions, and storage and pickup methods.
    Type: Application
    Filed: September 29, 2019
    Publication date: April 1, 2021
    Inventors: Changlin CHEN, Zhonghua CHAI, Lei SHEN
  • Publication number: 20200277634
    Abstract: This document describes biochemical pathways for producing pimeloyl-CoA using a polypeptide having the enzymatic activity of a hydroperoxide lyase to form non-3-enal and 9-oxononanoate from 9-hydroxyperoxyoctadec-10,12-dienoate. Non-3-enal and 9-oxononanoate can be enzymatically converted to pimeloyl-CoA or a salt thereof using one or more polypeptides having the activity of a dehydrogenase, a CoA ligase, an isomerase, a reductase, a thioesterase, a monooxygenase, a hydratase, and/or a thiolase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, or 1,7-heptanediol, or corresponding salts thereof. This document also describes recombinant microorganisms producing pimeloyl-CoA, as well as pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, and 1,7-heptanediol, or corresponding salts thereof.
    Type: Application
    Filed: October 18, 2019
    Publication date: September 3, 2020
    Applicant: INVISTA North America S.รก.r.l.
    Inventors: Alex Van Eck CONRADIE, Adriana L. BOTES, Alexander Brett FOSTER, Changlin CHEN
  • Patent number: 10752568
    Abstract: The present disclosure provides a method for preparing 1,3-propanediol by hydrolysis hydrogenolysis of glycerol and its corresponding reaction system, wherein, this method is to produce 1,3-propanediol through contact and reaction between hydrogen and glycerol under the catalysis of a noble metal/solid acid catalyst; wherein an auxiliary agent is contained in the liquid phase of the reaction system, and the content of the auxiliary agent in the liquid phase is 10 ppm or more.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: August 25, 2020
    Assignee: Zhangjiagang Glory Chemical Industry Co., Ltd.
    Inventors: Changlin Chen, Xiaodong Zhu, Bing Han, Chengchao Xiao
  • Patent number: 10689673
    Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: June 23, 2020
    Assignee: INVISTA North America S.a.r.l.
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie, Benjamin D. Herzog
  • Patent number: 10577634
    Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: March 3, 2020
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie, Benjamin D. Herzog
  • Publication number: 20190382811
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
    Type: Application
    Filed: November 26, 2018
    Publication date: December 19, 2019
    Inventors: Paul S. Pearlman, Alex Van Eck Conradie, Changlin Chen, Adriana Leonora Botes
  • Patent number: 10196657
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: February 5, 2019
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Paul S. Pearlman, Alex Van Eck Conradie, Changlin Chen, Adriana Leonora Botes
  • Publication number: 20180320205
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis.
    Type: Application
    Filed: February 1, 2018
    Publication date: November 8, 2018
    Inventors: Paul S. Pearlman, Alex Van Eck Conradie, Changlin Chen, Adriana Leonora Botes
  • Patent number: 9920336
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: March 20, 2018
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Paul S. Pearlman, Alex Van Eck Conradie, Changlin Chen, Adriana Leonora Botes
  • Publication number: 20180023097
    Abstract: Disclosed are methods for producing butadiene from one or more of several diverse feedstocks including bioderived feedstocks, renewable feedstocks, petrochemical feedstocks and natural gas.
    Type: Application
    Filed: April 21, 2017
    Publication date: January 25, 2018
    Applicant: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana Leonora Botes
  • Publication number: 20170369907
    Abstract: This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
    Type: Application
    Filed: June 29, 2017
    Publication date: December 28, 2017
    Inventors: Alex Van Eck Conradie, Adriana Leonora Botes, Changlin Chen, Paul S. Pearlman
  • Publication number: 20170306362
    Abstract: The invention relates to methods for enriching monomer content in a cycloalkane oxidation process mixed organic waste stream. In particular, the methods involve combining a biocatalyst with a mixed organic waste stream from a cycloalkane oxidation process, and enzymatically converting dimeric and/or oligomeric components of said waste stream into monomeric components. The methods may enrich the content of diacids, adipic acid, and/or other ?,?-difunctional C6 alkanes in the mixed organic waste stream. Additionally, the treated mixed organic waste streams may have improved burning efficiency.
    Type: Application
    Filed: April 4, 2017
    Publication date: October 26, 2017
    Inventors: Paul S. PEARLMAN, Changlin CHEN, Adriana Leonora BOTES
  • Publication number: 20170298396
    Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
    Type: Application
    Filed: March 20, 2017
    Publication date: October 19, 2017
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie, Benjamin D. Herzog
  • Patent number: 9783833
    Abstract: The invention relates to methods for enriching monomer content in a cycloalkane oxidation process mixed organic waste stream. In particular, the methods involve combining a biocatalyst with a mixed organic waste stream from a cycloalkane oxidation process, and enzymatically converting dimeric and/or oligomeric components of said waste stream into monomeric components. The methods may enrich the content of diacids, adipic acid, and/or other ?,?-difunctional C6 alkanes in the mixed organic waste stream. Additionally, the treated mixed organic waste streams may have improved burning efficiency.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: October 10, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana Leonora Botes
  • Publication number: 20170240933
    Abstract: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
    Type: Application
    Filed: February 24, 2017
    Publication date: August 24, 2017
    Inventors: Paul S. Pearlman, Alex Van Eck Conradie, Changlin Chen, Adriana Leonora Botes
  • Patent number: 9738911
    Abstract: This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: August 22, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Alex Van Eck Conradie, Adriana Leonora Botes, Changlin Chen, Paul S. Pearlman