Abstract: A tidal current energy generating device includes a generator, a connecting shaft, an impeller and an adjustment assembly. The impeller includes an impeller hub and an impeller blade arranged thereon. The impeller hub is connected with the connecting shaft, and the generator is connected with the impeller hub. The impeller blade is driven under the action of a tidal current to drive the impeller hub to rotate synchronously around an axis of the connecting shaft, driving the generator to generate electricity. The adjustment assembly is connected with the impeller blade, and can be driven to swing under the action of the tidal current to drive the impeller blade to rotate around the axis of the impeller blade relative to the impeller hub, thereby adjusting the angle of the impeller blade.

Abstract: Provided herein are methods of identifying an agent that activates a protease-activated receptor 2 (PAR2)intracellularly. Also provided are isolated mutant PAR2 polypeptides, isolated polynucleotides encoding the mutant PAR2 polypeptides, vectors comprising the isolated polynucleotides, and host cells comprising the vectors.

Abstract: A tidal current energy generating device includes a generator, a connecting shaft, an impeller and an adjustment assembly. The impeller includes an impeller hub and an impeller blade arranged thereon. The impeller hub is connected with the connecting shaft, and the generator is connected with the impeller hub. The impeller blade is driven under the action of a tidal current to drive the impeller hub to rotate synchronously around an axis of the connecting shaft, driving the generator to generate electricity. The adjustment assembly is connected with the impeller blade, and can be driven to swing under the action of the tidal current to drive the impeller blade to rotate around the axis of the impeller blade relative to the impeller hub, thereby adjusting the angle of the impeller blade.

Abstract: The present invention discloses a ducted bidirectional tidal current power station system, mainly consisting of a bidirectional tidal current power generation device, a dam, an open sea, an inland sea, a duct, and an opening/closing gate. The bidirectional tidal current power generation device is installed in the duct on the bottom of the dam. Openings, respectively communicated with the open sea and the inland sea, are formed at two ends of the duct, and an opening/closing gate is arranged at each of the two openings. By the ducted bidirectional tidal current power station system of the present invention, the cost of marine construction, operation and maintenance of the tidal current power generation device in an open sea area is saved, and the complex structure of the power generation device in the tidal power station and the cost of strict construction of auxiliary devices and runners are avoided.

Abstract: A tidal current generating unit, including a turbine, a hub, a generator, a bearing set and a fixed flange. The turbine is connected to the rotor of the generator through the hub, and the rotor is rotatably mounted on the outer circumference of the stator of the generator via the bearing set, and the turbine drives the rotating component to rotate to generate electricity. A density of a blade is much smaller than a density of the seawater, such that the blade has a sufficient buoyancy that offsets the gravity of the rotating component in seawater, and the load of the bearing sets is reduced. The blade is a backswept blade and the hydrodynamic central axis of the blade is inclined from a flange central axis of the blade at a first angle, and the blade is able to automatically change the pitch without relying on an external force.

Abstract: A tidal current generating unit, including a turbine, a hub, a generator, a bearing set and a fixed flange. The turbine is connected to the rotor of the generator through the hub, and the rotor is rotatably mounted on the outer circumference of the stator of the generator via the bearing set, and the turbine drives the rotating component to rotate to generate electricity. A density of a blade is much smaller than a density of the seawater, such that the blade has a sufficient buoyancy that offsets the gravity of the rotating component in seawater, and the load of the bearing sets is reduced. The blade is a backswept blade and the hydrodynamic central axis of the blade is inclined from a flange central axis of the blade at a first angle, and the blade is able to automatically change the pitch without relying on an external force.

Abstract: The present invention discloses a ducted bidirectional tidal current power station system, mainly consisting of a bidirectional tidal current power generation device, a dam, an open sea, an inland sea, a duct, and an opening/closing gate. The bidirectional tidal current power generation device is installed in the duct on the bottom of the dam. Openings, respectively communicated with the open sea and the inland sea, are formed at two ends of the duct, and an opening/closing gate is arranged at each of the two openings. By the ducted bidirectional tidal current power station system of the present invention, the cost of marine construction, operation and maintenance of the tidal current power generation device in an open sea area is saved, and the complex structure of the power generation device in the tidal power station and the cost of strict construction of auxiliary devices and runners are avoided.

Abstract: Provided herein are compounds capable of activating GPR139. Also provided are methods of increasing and decreasing the activity of GPR139. Methods of using the identified compounds to modulate GPR139 activity or conditions that may be affected by GPR139 activity are also disclosed.

Abstract: Provided herein are compounds capable of activating GPR139. Also provided are methods of increasing and decreasing the activity of GPR139. Methods of using the identified compounds to modulate GPR139 activity or conditions that may be affected by GPR139 activity are also disclosed.

Abstract: The chimeric polypeptide R3(B?23-27)R/I5 is described, which is a high-affinity antagonist for GPCR1 35 and GPCR1 42 over LGR7.

Abstract: Complexes of GPR81 receptor components and ligand components, such as L-lactate or GHB, may be used as an assay reagent for screening for modulators of GPR81 receptor activity.

Abstract: Complexes of GPR81 receptor components and ligand components, such as L-lactate or GHB, may be used as an assay reagent for screening for modulators of GPR81 receptor activity.

Abstract: Chimeric polypeptides of relaxin-3, prepropolypeptides thereof, polynucleotides encoding such polypeptides, and associated expression vectors and host cells are described. The polypeptides may be used to prepare receptor-ligand complexes with GPCR135 or GPCR142, which may be used in assay methods.

Abstract: The chimeric polypeptide R3(B?23-27)R/I5 is described, which is a high-affinity antagonist for GPCR1 35 and GPCR1 42 over LGR7.

Abstract: Canine 5-hydroxytryptamine 2 receptor materials are described, including polypeptides corresponding to SEQ ID NOs.:8 and 10 and polynucleotides expressing them corresponding to SEQ ID NOs.:7 and 9. Such materials are useful as reagents in drug screening assays to identify compounds having 5-HT2 receptor-modulating activity.

Abstract: A PK2? peptide is described, which, as an agonist of prokineticin receptor 1, is useful for treating lung and gastrointestinal diseases or disorders mediated by PKR1 activity.

Abstract: Canine 5-hydroxytryptamine 2 receptor materials are described, including polypeptides corresponding to SEQ ID NOs:8 and 10 and polynucleotides expressing them corresponding to SEQ ID NOs:7 and 9. Such materials are useful as reagents in drug screening assays to identify compounds having 5-HT2 receptor-modulating activity.

Abstract: Chimeric polypeptides of relaxin-3, prepropolypeptides thereof, polynucleotides encoding such polypeptides, and associated expression vectors and host cells are described. The polypeptides may be used to prepare receptor-ligand complexes with GPCR135 or GPCR142, which may be used in assay methods.

Abstract: DNAs encoding the mammalian histamine H4 receptors have been cloned and characterized. These recombinant molecules are capable of expressing biologically active histamine H4 receptor protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The pharmacology of known histamine ligands is demonstrated. The recombinant protein may be purified from the recombinant host cells. In addition, recombinant host cells are utilized to establish methods to identify modulators of the receptor activity, and receptor modulators are identified.

Abstract: DNAs encoding the mammalian histamine H4 receptors have been cloned and characterized. These recombinant molecules are capable of expressing biologically active histamine H4 receptor protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The pharmacology of known histamine ligands is demonstrated. The recombinant protein may be purified from the recombinant host cells. In addition, recombinant host cells are utilized to establish methods to identify modulators of the receptor activity, and receptor modulators are identified.