Patents by Inventor Changming Fang

Changming Fang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNE CHECKPOINT BLOCKING BISPECIFIC MOLECULES
    Publication number: 20220354960
    Abstract: The invention provides tumor targeting, immune checkpoint-blocking bispecific molecules. The bispecific molecules contain an anti-PD-L1 antibody or antigen-binding fragment, and a peptide agent that specifically binds to a surface antigen or cellular marker of a solid tumor. Also provided in the invention are methods of using such specific molecules in various therapeutic applications.
    Type: Application
    Filed: June 12, 2020
    Publication date: November 10, 2022
    Inventors: Peter Schultz, Feng Wang, Ray Changming Fang, Yu J. Cao, Weijun Shen, Xiaoxuan Lyu, Sam Lear
  • Compositions and methods for detection of colorectal cancer
    Patent number: 8563248
    Abstract: We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: October 22, 2013
    Inventors: Jeffrey W. Smith, Changming Fang
  • COMPOSITIONS AND METHODS FOR DETECTION OF COLORECTAL CANCER
    Publication number: 20110200996
    Abstract: We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.
    Type: Application
    Filed: December 2, 2010
    Publication date: August 18, 2011
    Inventors: Jeffrey W. Smith, Changming FANG
  • Compositions and methods for treatment of colorectal cancer
    Publication number: 20090074785
    Abstract: We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides, for example, compositions and methods for diagnosing and treating colorectal cancer.
    Type: Application
    Filed: January 16, 2008
    Publication date: March 19, 2009
    Inventors: Jeffrey W. Smith, Changming Fang
  • Compositions and Methods for Detection of Colorectal Cancer
    Publication number: 20090005307
    Abstract: We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.
    Type: Application
    Filed: September 21, 2006
    Publication date: January 1, 2009
    Applicant: BURNHAM INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Jeffrey W. Smith, Changming Fang